Nicotinamide riboside kinase 1

BE0020329ProteinHumansNMRK1

Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). It is acted on by 1 drug in DrugBank.

Gene name
NMRK1
UniProtKB entry
Q9NWW6Swiss-Prot
Residues / weight
199 residues · 23,193 Da
Also known as
2.7.1.22 · C9orf95 · Nicotinic acid riboside kinase 1 · NmR-K 1 · NRK 1

Resolves to

Protein
UniProtQ9NWW6UniProt nameNRK1_HUMAN
Gene
HGNCHGNC:26057NCBI Gene54981GeneCardsNMRK1
Pharmacology
KEGGhsa:54981
Structure
PDB2P0EPDB2QG6PDB2QL6
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Nicotinamide riboside kinase 1, how selective are they, and which programs against it are still in active trials?

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