Triggering receptor expressed on myeloid cells 2

BE0020451ProteinHumansTREM2

Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849). It is acted on by 1 drug in DrugBank.

Gene name
TREM2
UniProtKB entry
Q9NZC2Swiss-Prot
Cellular location
Cell membrane
Residues / weight
230 residues · 25,447 Da
Also known as
TREM-2 · Triggering receptor expressed on monocytes 2

Resolves to

Protein
UniProtQ9NZC2UniProt nameTREM2_HUMAN
Gene
HGNCHGNC:17761NCBI Gene54209GeneCardsTREM2
Pharmacology
IUPHAR/GtoPdb3331KEGGhsa:54209
Structure
PDB5ELIPDB5UD7PDB5UD8
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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129GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Triggering receptor expressed on myeloid cells 2, and which indications are they being tested in?

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