Sentrin-specific protease 1

BE0020514ProteinHumansSENP1

Protease that catalyzes two essential functions in the SUMO pathway (PubMed:10652325, PubMed:15199155, PubMed:15487983, PubMed:16253240, PubMed:16553580, PubMed:21829689, PubMed:21965678, PubMed:23160374, PubMed:24943844, PubMed:25406032, PubMed:29506078, PubMed:34048572, PubMed:37257451). It is acted on by 1 drug in DrugBank.

Gene name
SENP1
UniProtKB entry
Q9P0U3Swiss-Prot
Cellular location
Nucleus
Residues / weight
644 residues · 73,480 Da
Also known as
3.4.22.- · Sentrin/SUMO-specific protease SENP1

Resolves to

Protein
UniProtQ9P0U3UniProt nameSENP1_HUMAN
Gene
HGNCHGNC:17927NCBI Gene29843GeneCardsSENP1
Pharmacology
IUPHAR/GtoPdb2414KEGGhsa:29843
Structure
PDB2CKGPDB2CKHPDB2G4D
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Sentrin-specific protease 1, and which indications are they being tested in?

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