SUMO-activating enzyme subunit 1

BE0020638ProteinHumansSAE1

The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It is acted on by 1 drug in DrugBank.

Gene name
SAE1
UniProtKB entry
Q9UBE0Swiss-Prot
Cellular location
Nucleus
Residues / weight
346 residues · 38,450 Da
Also known as
AOS1 · SUA1 · Ubiquitin-like 1-activating enzyme E1A · UBLE1A

Resolves to

Protein
UniProtQ9UBE0UniProt nameSAE1_HUMAN
Gene
HGNCHGNC:30660NCBI Gene10055GeneCardsSAE1
Pharmacology
KEGGhsa:10055
Structure
PDB1Y8QPDB1Y8RPDB3KYC
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on SUMO-activating enzyme subunit 1, and which indications are they being tested in?

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