Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

BE0020703ProteinHumansPPARGC1A

Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:10713165, PubMed:20005308, PubMed:21376232, PubMed:28363985, PubMed:32433991). It is acted on by 1 drug in DrugBank.

Gene name
PPARGC1A
UniProtKB entry
Q9UBK2Swiss-Prot
Cellular location
Nucleus
Residues / weight
798 residues · 91,026 Da
Also known as
LEM6 · Ligand effect modulator 6 · PGC-1-alpha · PGC1 · PGC1A

Resolves to

Protein
UniProtQ9UBK2UniProt namePRGC1_HUMAN
Gene
HGNCHGNC:9237NCBI Gene10891GeneCardsPPARGC1A
Pharmacology
KEGGhsa:10891
Structure
PDB1XB7PDB3B1MPDB3CS8
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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47GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, and which indications are they being tested in?

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