Phosphatidylethanolamine N-methyltransferase

BE0020731ProteinHumansPEMT

Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure (PubMed:12431977, PubMed:15927961). It is acted on by 1 drug in DrugBank.

Gene name
PEMT
UniProtKB entry
Q9UBM1Swiss-Prot
Cellular location
Endoplasmic reticulum
Residues / weight
199 residues · 22,134 Da
Also known as
2.1.1.17 · 2.1.1.71 · PEAMT · PEMPT · PEMT

Resolves to

Protein
UniProtQ9UBM1UniProt namePEMT_HUMAN
Gene
HGNCHGNC:8830NCBI Gene10400GeneCardsPEMT
Pharmacology
KEGGhsa:10400
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Pfam domainDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Phosphatidylethanolamine N-methyltransferase, and which indications are they being tested in?

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