SUMO-activating enzyme subunit 2

BE0020840ProteinHumansUBA2

The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It is acted on by 1 drug in DrugBank.

Gene name
UBA2
UniProtKB entry
Q9UBT2Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
640 residues · 71,223 Da
Also known as
2.3.2.- · Anthracycline-associated resistance ARX · SAE2 · Ubiquitin-like 1-activating enzyme E1B · Ubiquitin-like modifier-activating enzyme 2

Resolves to

Protein
UniProtQ9UBT2UniProt nameSAE2_HUMAN
Gene
HGNCHGNC:30661NCBI Gene10054GeneCardsUBA2
Pharmacology
KEGGhsa:10054
Structure
PDB1Y8QPDB1Y8RPDB2PX9
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
12GO termsFunction, process and component, as structured annotations
Sign in
3Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
3+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on SUMO-activating enzyme subunit 2, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In