Protein argonaute-2

BE0020979ProteinHumansAGO2

Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). It is acted on by 1 drug in DrugBank.

Gene name
AGO2
UniProtKB entry
Q9UKV8Swiss-Prot
Cellular location
Cytoplasm, P-body
Residues / weight
859 residues · 97,208 Da
Also known as
3.1.26.n2 · Argonaute RISC catalytic component 2 · Argonaute2 · eIF-2C 2 · eIF2C 2

Resolves to

Protein
UniProtQ9UKV8UniProt nameAGO2_HUMAN
Gene
HGNCHGNC:3263NCBI Gene27161GeneCardsAGO2
Pharmacology
KEGGhsa:27161
Structure
PDB3LUCPDB3LUDPDB3LUG
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Protein argonaute-2, and which indications are they being tested in?

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