Cleavage and polyadenylation specificity factor subunit 3

BE0021153ProteinHumansCPSF3

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about... It is acted on by 1 drug in DrugBank.

Gene name
CPSF3
UniProtKB entry
Q9UKF6Swiss-Prot
Cellular location
Nucleus
Residues / weight
684 residues · 77,485 Da
Also known as
3.1.27.- · Cleavage and polyadenylation specificity factor 73 kDa subunit · CPSF 73 kDa subunit · CPSF73 · mRNA 3'-end-processing endonuclease CPSF-73

Resolves to

Protein
UniProtQ9UKF6UniProt nameCPSF3_HUMAN
Gene
HGNCHGNC:2326NCBI Gene51692GeneCardsCPSF3
Pharmacology
KEGGhsa:51692
Structure
PDB2I7TPDB2I7VPDB6M8Q
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Cleavage and polyadenylation specificity factor subunit 3, and which indications are they being tested in?

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