Endoribonuclease Dicer

BE0021177ProteinHumansDICER1

Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. It is acted on by 2 drugs in DrugBank.

Gene name
DICER1
UniProtKB entry
Q9UPY3Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
1,922 residues · 218,679 Da
Also known as
3.1.26.3 · DICER · Helicase MOI · Helicase with RNase motif · HERNA

Resolves to

Protein
UniProtQ9UPY3UniProt nameDICER_HUMAN
Gene
HGNCHGNC:17098NCBI Gene23405GeneCardsDICER1
Pharmacology
KEGGhsa:23405
Structure
PDB21CBPDB21CNPDB21CQ
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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34GO termsFunction, process and component, as structured annotations
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8Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Endoribonuclease Dicer, how selective are they, and which programs against it are still in active trials?

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