Phospholipid-transporting ATPase IF

BE0021215ProteinHumansATP11B

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of intracellular membranes (PubMed:30018401). It is acted on by 1 drug in DrugBank.

Gene name
ATP11B
UniProtKB entry
Q9Y2G3Swiss-Prot
Cellular location
Recycling endosome membrane
Residues / weight
1,177 residues · 134,189 Da
Also known as
7.6.2.1 · ATPase class VI type 11B · ATPase IR · ATPIF · ATPIR

Resolves to

Protein
UniProtQ9Y2G3UniProt nameAT11B_HUMAN
Gene
HGNCHGNC:13553NCBI Gene23200GeneCardsATP11B
Pharmacology
KEGGhsa:23200
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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21GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Phospholipid-transporting ATPase IF, and which indications are they being tested in?

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