F-box/WD repeat-containing protein 1A

BE0021224ProteinHumansBTRC

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:10066435, PubMed:10497169, PubMed:10644755, PubMed:10835356, PubMed:11158290, PubMed:11238952, PubMed:11359933, PubMed:11994270, PubMed:12791267, PubMed:12902344, PubMed:14603323, PubMed:14681206,... It is acted on by 1 drug in DrugBank.

Gene name
BTRC
UniProtKB entry
Q9Y297Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
605 residues · 68,866 Da
Also known as
BTRCP · E3RSIkappaB · Epididymis tissue protein Li 2a · F-box and WD repeats protein beta-TrCP · FBW1A

Resolves to

Protein
UniProtQ9Y297UniProt nameFBW1A_HUMAN
Gene
HGNCHGNC:1144NCBI Gene8945GeneCardsBTRC
Pharmacology
KEGGhsa:8945
Structure
PDB1P22PDB2P64PDB6M90
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on F-box/WD repeat-containing protein 1A, and which indications are they being tested in?

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