E3 ubiquitin-protein ligase CHIP

BE0021260ProteinHumansSTUB1

E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation (PubMed:10330192, PubMed:11146632, PubMed:11557750, PubMed:23990462, PubMed:26265139). It is acted on by 1 drug in DrugBank.

Gene name
STUB1
UniProtKB entry
Q9UNE7Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
303 residues · 34,856 Da
Also known as
2.3.2.27 · Antigen NY-CO-7 · Carboxy terminus of Hsp70-interacting protein · CHIP · CLL-associated antigen KW-8

Resolves to

Protein
UniProtQ9UNE7UniProt nameCHIP_HUMAN
Gene
HGNCHGNC:11427NCBI Gene10273GeneCardsSTUB1
Pharmacology
IUPHAR/GtoPdb3202KEGGhsa:10273
Structure
PDB4KBQPDB6EFKPDB6NSV
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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60GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on E3 ubiquitin-protein ligase CHIP, and which indications are they being tested in?

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