Insulin receptor substrate 2

BE0021286ProteinHumansIRS2

Signaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670). It is acted on by 1 drug in DrugBank.

Gene name
IRS2
UniProtKB entry
Q9Y4H2Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
1,338 residues · 137,333 Da
Also known as
IRS-2

Resolves to

Protein
UniProtQ9Y4H2UniProt nameIRS2_HUMAN
Gene
HGNCHGNC:6126NCBI Gene8660GeneCardsIRS2
Pharmacology
KEGGhsa:8660
Structure
PDB3FQWPDB3FQX
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
32GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
1+ReferenceStructured and connected to the statements they support
Sign in

Which compounds in development act on Insulin receptor substrate 2, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In