Insulin-induced gene 2 protein

BE0021304ProteinHumansINSIG2

Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR (PubMed:12242332, PubMed:16606821, PubMed:32322062). It is acted on by 1 drug in DrugBank.

Gene name
INSIG2
UniProtKB entry
Q9Y5U4Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
225 residues · 24,778 Da
Also known as
INSIG-2

Resolves to

Protein
UniProtQ9Y5U4UniProt nameINSI2_HUMAN
Gene
HGNCHGNC:20452NCBI Gene51141GeneCardsINSIG2
Pharmacology
KEGGhsa:51141
Structure
PDB4J82PDB6M49PDB7ETW
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Insulin-induced gene 2 protein, and which indications are they being tested in?

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