TNF receptor-associated factor 6

BE0021309ProteinHumansTRAF6

E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as ECSIT, IKBKG, IRAK1, AKT1 and AKT2 (PubMed:11057907, PubMed:18347055, PubMed:19465916, PubMed:19713527, PubMed:27746020, PubMed:31620128). It is acted on by 1 drug in DrugBank.

Gene name
TRAF6
UniProtKB entry
Q9Y4K3Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
522 residues · 59,573 Da
Also known as
2.3.2.27 · E3 ubiquitin-protein ligase TRAF6 · Interleukin-1 signal transducer · RING finger protein 85 · RING-type E3 ubiquitin transferase TRAF6

Resolves to

Protein
UniProtQ9Y4K3UniProt nameTRAF6_HUMAN
Gene
HGNCHGNC:12036NCBI Gene7189GeneCardsTRAF6
Pharmacology
KEGGhsa:7189
Structure
PDB1LB4PDB1LB5PDB1LB6
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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71GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on TNF receptor-associated factor 6, how selective are they, and which programs against it are still in active trials?

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