Endothelial lipase

Details

Name
Endothelial lipase
Kind
protein
Synonyms
  • 3.1.1.3
  • EDL
  • EL
  • Endothelial cell-derived lipase
  • Phospholipase A1
Gene Name
LIPG
UniProtKB Entry
Q9Y5X9Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0064224|Endothelial lipase
MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPE
HEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVV
VDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGN
FVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHID
IYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDS
NRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKN
MGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGAS
QSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWF
RKCRDGWRMKNETSPTVELP
Number of residues
500
Molecular Weight
56794.275
Theoretical pI
Not Available
GO Classification
Functions
1-acyl-2-lysophosphatidylserine acylhydrolase activity / heparin binding / lipoprotein lipase activity / phosphatidylserine 1-acylhydrolase activity / phospholipase A1 activity / phospholipase activity / triglyceride lipase activity
Processes
cholesterol homeostasis / fatty acid biosynthetic process / high-density lipoprotein particle remodeling / lipid metabolic process / phospholipid catabolic process / phospholipid homeostasis / positive regulation of cholesterol transport / positive regulation of high-density lipoprotein particle clearance / regulation of lipoprotein metabolic process / response to nutrient / reverse cholesterol transport / triglyceride catabolic process
Components
cell surface / early endosome / extracellular region / extracellular space / Golgi apparatus
General Function
Exerts both phospholipase and triglyceride lipase activities (PubMed:10192396, PubMed:10318835, PubMed:12032167). More active as a phospholipase than a triglyceride lipase (PubMed:12032167). Hydrolyzes triglycerides, both with short-chain fatty acyl groups (tributyrin) and long-chain fatty acyl groups (triolein) with similar levels of activity toward both types of substrates (PubMed:12032167). Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins (PubMed:10192396, PubMed:12032167)
Specific Function
1-acyl-2-lysophosphatidylserine acylhydrolase activity
Pfam Domain Function
Signal Regions
1-20
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
Not Available
Chromosome Location
18
Locus
18q21.1
External Identifiers
ResourceLink
UniProtKB IDQ9Y5X9
UniProtKB Entry NameLIPG_HUMAN
GeneCard IDLIPG
HGNC IDHGNC:6623
KEGG IDhsa:9388
IUPHAR/Guide To Pharmacology ID2591
NCBI Gene ID9388
General References
Not Available

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
CetilistatinvestigationalyestargetmodulatorDetails