Endothelial lipase
Details
- Name
- Endothelial lipase
- Kind
- protein
- Synonyms
- 3.1.1.3
- EDL
- EL
- Endothelial cell-derived lipase
- Phospholipase A1
- Gene Name
- LIPG
- UniProtKB Entry
- Q9Y5X9Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0064224|Endothelial lipase MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPE HEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVV VDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGN FVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHID IYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDS NRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKN MGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGAS QSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWF RKCRDGWRMKNETSPTVELP
- Number of residues
- 500
- Molecular Weight
- 56794.275
- Theoretical pI
- Not Available
- GO Classification
- Functions1-acyl-2-lysophosphatidylserine acylhydrolase activity / heparin binding / lipoprotein lipase activity / phosphatidylserine 1-acylhydrolase activity / phospholipase A1 activity / phospholipase activity / triglyceride lipase activityProcessescholesterol homeostasis / fatty acid biosynthetic process / high-density lipoprotein particle remodeling / lipid metabolic process / phospholipid catabolic process / phospholipid homeostasis / positive regulation of cholesterol transport / positive regulation of high-density lipoprotein particle clearance / regulation of lipoprotein metabolic process / response to nutrient / reverse cholesterol transport / triglyceride catabolic processComponentscell surface / early endosome / extracellular region / extracellular space / Golgi apparatus
- General Function
- Exerts both phospholipase and triglyceride lipase activities (PubMed:10192396, PubMed:10318835, PubMed:12032167). More active as a phospholipase than a triglyceride lipase (PubMed:12032167). Hydrolyzes triglycerides, both with short-chain fatty acyl groups (tributyrin) and long-chain fatty acyl groups (triolein) with similar levels of activity toward both types of substrates (PubMed:12032167). Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins (PubMed:10192396, PubMed:12032167)
- Specific Function
- 1-acyl-2-lysophosphatidylserine acylhydrolase activity
- Pfam Domain Function
- Signal Regions
- 1-20
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
- Not Available
- Chromosome Location
- 18
- Locus
- 18q21.1
- External Identifiers
Resource Link UniProtKB ID Q9Y5X9 UniProtKB Entry Name LIPG_HUMAN GeneCard ID LIPG HGNC ID HGNC:6623 KEGG ID hsa:9388 IUPHAR/Guide To Pharmacology ID 2591 NCBI Gene ID 9388 - General References
- Not Available
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Cetilistat investigational yes target modulator Details