Sulfide:quinone oxidoreductase, mitochondrial

BE0021395ProteinHumansSQOR

Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone-10, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. It is acted on by 1 drug in DrugBank.

Gene name
SQOR
UniProtKB entry
Q9Y6N5Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
450 residues · 49,960 Da
Also known as
1.8.5.8 · SQOR · SQRDL · Sulfide dehydrogenase-like · Sulfide quinone oxidoreductase

Resolves to

Protein
UniProtQ9Y6N5UniProt nameSQOR_HUMAN
Gene
HGNCHGNC:20390NCBI Gene58472GeneCardsSQOR
Pharmacology
KEGGhsa:58472
Structure
PDB6MO6PDB6MP5PDB6OI5
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on Sulfide:quinone oxidoreductase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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