Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

BE0021514ProteinHumansSAMHD1

Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (PubMed:19525956, PubMed:21613998, PubMed:21720370, PubMed:22056990, PubMed:23601106, PubMed:23602554, PubMed:24336198, PubMed:26294762,... It is acted on by 1 drug in DrugBank.

Gene name
SAMHD1
UniProtKB entry
Q9Y3Z3Swiss-Prot
Cellular location
Nucleus
Residues / weight
626 residues · 72,200 Da
Also known as
3.1.5.- · DCIP · Dendritic cell-derived IFNG-induced protein · dNTPase · hSAMHD1

Resolves to

Protein
UniProtQ9Y3Z3UniProt nameSAMH1_HUMAN
Gene
HGNCHGNC:15925NCBI Gene25939GeneCardsSAMHD1
Pharmacology
IUPHAR/GtoPdb3330KEGGhsa:25939
Structure
PDB2E8OPDB3U1NPDB4BZB
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, and which indications are they being tested in?

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