Ubiquitin carboxyl-terminal hydrolase isozyme L5

BE0021572ProteinHumansUCHL5

Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. It is acted on by 1 drug in DrugBank.

Gene name
UCHL5
UniProtKB entry
Q9Y5K5Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
329 residues · 37,607 Da
Also known as
3.4.19.12 · Ubiquitin C-terminal hydrolase UCH37 · Ubiquitin thioesterase L5 · UCH-L5 · UCH37

Resolves to

Protein
UniProtQ9Y5K5UniProt nameUCHL5_HUMAN
Gene
HGNCHGNC:19678NCBI Gene51377GeneCardsUCHL5
Pharmacology
KEGGhsa:51377
Structure
PDB3A7SPDB3IHRPDB3RII
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
20GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
3+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Ubiquitin carboxyl-terminal hydrolase isozyme L5, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In