Ubiquitin carboxyl-terminal hydrolase isozyme L5

BE0021572ProteinHumansUCHL5

Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. It is acted on by 1 drug in DrugBank.

Gene name
UCHL5
UniProtKB entry
Q9Y5K5Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
329 residues · 37,607 Da
Also known as
3.4.19.12 · Ubiquitin C-terminal hydrolase UCH37 · Ubiquitin thioesterase L5 · UCH-L5 · UCH37

Resolves to

Protein
UniProtQ9Y5K5UniProt nameUCHL5_HUMAN
Gene
HGNCHGNC:19678NCBI Gene51377GeneCardsUCHL5
Pharmacology
KEGGhsa:51377
Structure
PDB3A7SPDB3IHRPDB3RII
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Ubiquitin carboxyl-terminal hydrolase isozyme L5, and which indications are they being tested in?

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