G protein-coupled receptor 6

BE0021832ProteinHumansGPR6

Constitutively active G protein-coupled receptor that maintains high cAMP levels and contributes to several processes including neuronal development, through activation of intracellular signaling pathways via G(s). It is acted on by 1 drug in DrugBank.

Gene name
GPR6
UniProtKB entry
P46095Swiss-Prot
Cellular location
Cell membrane
Residues / weight
362 residues · 37,881 Da
Also known as
Sphingosine 1-phosphate receptor GPR6

Resolves to

Protein
UniProtP46095UniProt nameGPR6_HUMAN
Gene
HGNCHGNC:4515NCBI Gene2830GeneCardsGPR6
Pharmacology
IUPHAR/GtoPdb85KEGGhsa:2830
Structure
PDB8T1VPDB8T1WPDB8TF5
Drugs

What you can answer from here — as of June 19, 2026

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on G protein-coupled receptor 6, and which indications are they being tested in?

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