Glutamate-gated chloride channel alpha

BE0027481ProteinCaenorhabditis elegansglc-1

Glutamate-gated chloride channel subunit; channel properties depend on the subunit composition. It is acted on by 1 drug in DrugBank.

Gene name
glc-1
UniProtKB entry
G5EBR3Swiss-Prot
Cellular location
Postsynaptic cell membrane
Residues / weight
461 residues · 52,552 Da
Also known as
Avermectin-sensitive glutamate-gated chloride channel GluCl alpha · GluCl alpha

Resolves to

Protein
UniProtG5EBR3UniProt nameGLUCL_CAEEL
Gene
NCBI Gene180086
Pharmacology
KEGGcel:CELE_F11A5.10
Structure
PDB3RHWPDB3RI5PDB3RIA
Drugs

What you can answer from here — as of November 28, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on Glutamate-gated chloride channel alpha, how selective are they, and which programs against it are still in active trials?

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