Haloalkane dehalogenase

BE0027482ProteinSphingobium indicum (strain DSM 16413 / CCM 7287 / MTCC 6362 / UT26 / NBRC 101211 / UT26S)linB

Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons. It is acted on by 8 drugs in DrugBank.

Gene name
linB
UniProtKB entry
D4Z2G1Swiss-Prot
Cellular location
Periplasm
Residues / weight
296 residues · 33,107 Da
Also known as
1,3,4,6-tetrachloro-1,4-cyclohexadiene halidohydrolase · 1,4-TCDN halidohydrolase · 3.8.1.5

Resolves to

Protein
UniProtD4Z2G1UniProt nameLINB_SPHIU
Pharmacology
KEGGsjp:SJA_C1-19590
Structure
PDB1CV2PDB1D07PDB1G42
Drugs

What you can answer from here — as of November 28, 2024

8DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Haloalkane dehalogenase, how selective are they, and which programs against it are still in active trials?

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