DNA gyrase subunit B

BE0027700ProteinNeisseria gonorrhoeae (strain ATCC 700825 / FA 1090)gyrB

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. It is acted on by 1 drug in DrugBank.

Gene name
gyrB
UniProtKB entry
Q5F5Z6Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
796 residues · 88,209 Da
Also known as
5.6.2.2

Resolves to

Protein
UniProtQ5F5Z6UniProt nameGYRB_NEIG1
Gene
NCBI Gene66754375
Pharmacology
KEGGngo:NGO_1772
Drugs

What you can answer from here — as of December 16, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA gyrase subunit B, how selective are they, and which programs against it are still in active trials?

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