Ganglionic Stimulants

Accession Number

DBCAT000446

Description

Agents that mimic neural transmission by stimulation of the nicotinic receptors on postganglionic autonomic neurons. Drugs that indirectly augment ganglionic transmission by increasing the release or slowing the breakdown of acetylcholine or by non-nicotinic effects on postganglionic neurons are not included here nor are the nonspecific cholinergic agonists.

Drugs

Drug	Drug Description
Tetramethylammonium	Not Available
Nicotine	A stimulatory alkaloid found in tobacco products that is often used for the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.
Lobeline	Investigated for use/treatment in addictions.

Drugs & Drug Targets

Drug	Target	Type
Tetramethylammonium	UDP-glucose 4-epimerase	target
Nicotine	Neuronal acetylcholine receptor subunit alpha-2	target
Nicotine	Neuronal acetylcholine receptor subunit beta-2	target
Nicotine	Neuronal acetylcholine receptor subunit alpha-7	target
Nicotine	Neuronal acetylcholine receptor subunit alpha-4	target
Nicotine	Neuronal acetylcholine receptor subunit alpha-10	target
Nicotine	Neuronal acetylcholine receptor subunit alpha-9	target
Nicotine	Cytochrome P450 2A6	enzyme
Nicotine	Cytochrome P450 2E1	enzyme
Nicotine	Cytochrome P450 2A13	enzyme
Nicotine	Cytochrome P450 2B6	enzyme
Nicotine	Neuronal acetylcholine receptor subunit beta-4	target
Nicotine	Neuronal acetylcholine receptor subunit alpha-3	target
Nicotine	Neuronal acetylcholine receptor subunit alpha-5	target
Nicotine	Neuronal acetylcholine receptor subunit alpha-6	target
Nicotine	Neuronal acetylcholine receptor subunit beta-3	target
Nicotine	Solute carrier family 22 member 2	transporter
Nicotine	Solute carrier family 22 member 1	transporter
Nicotine	Solute carrier family 22 member 3	transporter
Nicotine	Solute carrier family 22 member 5	transporter
Nicotine	Solute carrier family 22 member 4	transporter
Nicotine	Cytochrome P450 1A1	enzyme
Nicotine	Cytochrome P450 1A2	enzyme
Nicotine	Cytochrome P450 2C19	enzyme
Nicotine	Cytochrome P450 2C8	enzyme
Nicotine	Cytochrome P450 2C9	enzyme
Nicotine	Cytochrome P450 2D6	enzyme
Nicotine	Cytochrome P450 3A4	enzyme
Nicotine	Amine oxidase [flavin-containing] A	enzyme
Nicotine	Amine oxidase [flavin-containing] B	enzyme
Nicotine	Cytochrome P450 19A1	target
Nicotine	Choline O-acetyltransferase	target
Lobeline	Neuronal acetylcholine receptor subunit alpha-9	target
Lobeline	Neuronal acetylcholine receptor subunit alpha-10	target
Lobeline	Neuronal acetylcholine receptor subunit alpha-7	target