Calcimimetic Agents
- Name
- Calcimimetic Agents
- Accession Number
- DBCAT001231
- Description
Small organic molecules that act as allosteric activators of the calcium sensing receptor (CaSR) in the PARATHYROID GLANDS and other tissues. They lower the threshold for CaSR activation by extracellular calcium ions and diminish PARATHYROID HORMONE (PTH) release from parathyroid cells.
- Drugs
Drug Drug Description Cinacalcet A calcium sensing receptor agonist used to treat secondary hyperparathyroidism in chronic kidney disease and hypercalcemia in parathyroid carcinoma. - Drugs & Drug Targets
Drug Target Type Cinacalcet Extracellular calcium-sensing receptor target Cinacalcet Cytochrome P450 3A4 enzyme Cinacalcet Cytochrome P450 2D6 enzyme Cinacalcet Cytochrome P450 1A2 enzyme