Orexin Receptor Antagonists

All categories
Name
Orexin Receptor Antagonists
Accession Number
DBCAT001938
Description

Substances that bind to and inhibit the action of OREXIN RECEPTORS. Drugs in this class have been used as SLEEP AIDS.

ATC Classification
Drugs
DrugDrug Description
SuvorexantA orexin receptor antagonist used to treat insomnia that is characterized by difficulties with sleep onset and/or sleep maintenance.
LemborexantA dual orexin antagonist indicated for the treatment of sleep-onset and/or sleep maintenance insomnia.
DaridorexantA dual orexin receptor antagonist used to treat insomnia in adults.
Drugs & Drug Targets
DrugTargetType
SuvorexantOrexin receptor type 1target
SuvorexantOrexin receptor type 2target
SuvorexantCytochrome P450 3A4enzyme
SuvorexantP-glycoprotein 1transporter
LemborexantOrexin receptor type 1target
LemborexantOrexin receptor type 2target
LemborexantCytochrome P450 3A4enzyme
LemborexantCytochrome P450 3A5enzyme
LemborexantCytochrome P450 3A Subfamilyenzyme
LemborexantCytochrome P450 2B6enzyme
LemborexantP-glycoprotein 1transporter
DaridorexantCytochrome P450 3A4enzyme
DaridorexantOrexin receptor type 1target
DaridorexantOrexin receptor type 2target