Progesterone Receptor Modulators

Accession Number

DBCAT002473

Description

Not Available

ATC Classification

Drugs

Drug	Drug Description
Mifepristone	A cortisol receptor blocker used to treat Cushing's syndrome, and to terminate pregnancies up to 70 days gestation.
Ulipristal	A selective progesterone receptor modulator used for emergency contraception after unprotected intercourse or in a situation where a planned method of contraception has failed.

Drugs & Drug Targets

Drug	Target	Type
Mifepristone	Progesterone receptor	target
Mifepristone	Glucocorticoid receptor	target
Mifepristone	Cytochrome P450 3A4	enzyme
Mifepristone	Cytochrome P450 3A5	enzyme
Mifepristone	P-glycoprotein 1	transporter
Mifepristone	Multidrug resistance-associated protein 1	transporter
Mifepristone	Cytochrome P450 2D6	enzyme
Mifepristone	Prostate-specific antigen	target
Mifepristone	Nuclear receptor subfamily 1 group I member 2	target
Mifepristone	Bile salt export pump	transporter
Mifepristone	Cytochrome P450 2C8	enzyme
Mifepristone	Cytochrome P450 2C9	enzyme
Mifepristone	Solute carrier organic anion transporter family member 1B1	transporter
Mifepristone	Solute carrier organic anion transporter family member 1B3	transporter
Ulipristal	Progesterone receptor	target
Ulipristal	Glucocorticoid receptor	target
Ulipristal	Androgen receptor	target
Ulipristal	Cytochrome P450 3A4	enzyme
Ulipristal	Cytochrome P450 1A2	enzyme
Ulipristal	Serum albumin	carrier
Ulipristal	Alpha-1-acid glycoprotein 1	carrier