Peripheral Opioid Receptor Antagonists
- Peripheral Opioid Receptor Antagonists
- Accession Number
Opioid receptor antagonists which act primarily on peripheral receptors due to limited ability to cross the blood brain barrier. Typically used to treat opioid-induced constipation.
- ATC Classification
Drug Drug Description Alvimopan An opioid antagonist used to reduce healing time of the upper and lower gastrointestinal tract following surgical procedures that involve bowel resection with primary anastomosis. Methylnaltrexone A μ-opioid antagonist used for the treatment of opioid-induced constipation in palliative patients that are inadequately responding to laxative therapy. Naloxegol A peripherally-selective opioid antagonist used to treat opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain. Naloxone An opioid receptor antagonist used to rapidly reverse an opioid overdose. Also included in some drug formulations as an abuse deterrent to prevent injection. Naldemedine An opioid antagonist used to to treat opioid-induced constipation.
- Drugs & Drug Targets