Receptors, Peptide

Name
Receptors, Peptide
Accession Number
DBCAT002949
Description

Cell surface receptors that bind peptide messengers with high affinity and regulate intracellular signals which influence the behavior of cells.

Drugs
DrugDrug Description
Thrombomodulin AlfaInvestigated for use/treatment in blood preservative, blood (blood forming organ disorders, unspecified), sepsis and septicemia, and thrombosis.
Nelipepimut-SInvestigated for use/treatment in prostate cancer and breast cancer.
AfliberceptA vascular endothelial growth factor (VEGF) inhibitor used to treat Neovascular (Wet) Age-Related Macular Degeneration (AMD), various types of macular edema and diabetic retinopathy, and metastatic colorectal cancer
LuspaterceptAn erythroid maturation agent used to treat anemia secondary to beta thalassemia, myelodysplastic syndromes, and neoplasms.
DalanterceptDalantercept is under investigation in clinical trial NCT00996957 (Study of ACE-041 in Patients With Advanced Solid Tumors or Relapsed/Refractory Multiple Myeloma).
VEGFR2-169VEGFR2-169 is under investigation in clinical trial NCT00655785 (Antiangiogenic Peptide Vaccine Therapy With Gemcitabine in Treating Patient With Pancreatic Cancer (Phase1/2)).
VasomeraNot Available
LixisenatideA GLP-1 receptor agonist used for the management of type 2 diabetes mellitus.
TirzepatideA dual GIP and GLP-1 receptor agonist used for the treatment of type II diabetes in adults as an adjunct to diet and exercise.
Drugs & Drug Targets
DrugTargetType
Thrombomodulin AlfaCoagulation factor Vtarget
Thrombomodulin AlfaProthrombintarget
Nelipepimut-SHLA class I histocompatibility antigen, A-2 alpha chaintarget
Nelipepimut-SHLA class I histocompatibility antigen, A-3 alpha chaintarget
AfliberceptVascular endothelial growth factor Atarget
AfliberceptPlacenta growth factortarget
AfliberceptVascular endothelial growth factor Btarget
LixisenatideGlucagon-like peptide 1 receptortarget
TirzepatideGlucagon-like peptide 1 receptortarget
TirzepatideGastric inhibitory polypeptidetarget
TirzepatideSerum albumincarrier