Substance P/Neurokinin-1 Receptor Antagonist

Name
Substance P/Neurokinin-1 Receptor Antagonist
Accession Number
DBCAT003389
Description

Not Available

Drugs
DrugDrug Description
AprepitantA substance P/neurokinin 1 receptor antagonist used to treat nausea and vomiting caused by chemotherapy and surgery.
FosaprepitantAn antiemetic drug used in combination with other antiemetic agents for the prevention of acute and delayed nausea and vomiting caused by chemotherapy.
NetupitantAn antiemetic agent used in combination with palonosetron to prevent acute and delayed vomiting and nausea caused by chemotherapy.
RolapitantA neurokinin-1 (NK-1) receptor antagonist used in combination with other antiemetics for the prevention of delayed nausea and vomiting associated with emetogenic chemotherapy.
FosnetupitantA medication used in combination with others to prevent chemotherapy associated nausea and vomiting.
Drugs & Drug Targets
DrugTargetType
AprepitantNeurokinin 1 receptortarget
AprepitantCytochrome P450 3A4enzyme
AprepitantCytochrome P450 2C9enzyme
AprepitantCytochrome P450 2C19enzyme
FosaprepitantCytochrome P450 3A4enzyme
FosaprepitantCytochrome P450 2C9enzyme
NetupitantNeurokinin 1 receptortarget
NetupitantCytochrome P450 3A43enzyme
NetupitantCytochrome P450 2C9enzyme
NetupitantCytochrome P450 2D6enzyme
NetupitantCytochrome P450 3A4enzyme
NetupitantP-glycoprotein 1transporter
RolapitantNeurokinin 1 receptortarget
RolapitantCytochrome P450 2D6enzyme
RolapitantCytochrome P450 3A4enzyme
RolapitantATP-binding cassette sub-family G member 2transporter
RolapitantP-glycoprotein 1transporter
FosnetupitantCytochrome P450 3A4enzyme
FosnetupitantNeurokinin 1 receptortarget