Neurokinin 1 Antagonists
- Name
- Neurokinin 1 Antagonists
- Accession Number
- DBCAT004213
- Description
Not Available
- Drugs
Drug Drug Description Fosaprepitant An antiemetic drug used in combination with other antiemetic agents for the prevention of acute and delayed nausea and vomiting caused by chemotherapy. Netupitant An antiemetic agent used in combination with palonosetron to prevent acute and delayed vomiting and nausea caused by chemotherapy. Rolapitant A neurokinin-1 (NK-1) receptor antagonist used in combination with other antiemetics for the prevention of delayed nausea and vomiting associated with emetogenic chemotherapy. Aprepitant A substance P/neurokinin 1 receptor antagonist used to treat nausea and vomiting caused by chemotherapy and surgery. - Drugs & Drug Targets
Drug Target Type Fosaprepitant Cytochrome P450 3A4 enzyme Fosaprepitant Cytochrome P450 2C9 enzyme Netupitant Neurokinin 1 receptor target Netupitant Cytochrome P450 3A43 enzyme Netupitant Cytochrome P450 2C9 enzyme Netupitant Cytochrome P450 2D6 enzyme Netupitant Cytochrome P450 3A4 enzyme Netupitant P-glycoprotein 1 transporter Rolapitant Neurokinin 1 receptor target Rolapitant Cytochrome P450 2D6 enzyme Rolapitant Cytochrome P450 3A4 enzyme Rolapitant ATP-binding cassette sub-family G member 2 transporter Rolapitant P-glycoprotein 1 transporter Aprepitant Neurokinin 1 receptor target Aprepitant Cytochrome P450 3A4 enzyme Aprepitant Cytochrome P450 2C9 enzyme Aprepitant Cytochrome P450 2C19 enzyme