Smoking Cessation Agents

Name
Smoking Cessation Agents
Accession Number
DBCAT004978
Description

Substances that facilitate the cessation of tobacco smoking.

Drugs
DrugDrug Description
NicotineA stimulatory alkaloid found in tobacco products that is often used for the relief of nicotine withdrawal symptoms and as an aid to smoking cessation.
BupropionA norepinephrine and dopamine reuptake inhibitor used in the treatment of major depressive disorder (MDD), seasonal affective disorder (SAD), and as an aid to smoking cessation.
VareniclineA partial agonist at nicotinic acetylcholine receptors used as an aid in smoking cessation.
Drugs & Drug Targets
DrugTargetType
NicotineNeuronal acetylcholine receptor subunit alpha-2target
NicotineNeuronal acetylcholine receptor subunit beta-2target
NicotineNeuronal acetylcholine receptor subunit alpha-7target
NicotineNeuronal acetylcholine receptor subunit alpha-4target
NicotineNeuronal acetylcholine receptor subunit alpha-10target
NicotineNeuronal acetylcholine receptor subunit alpha-9target
NicotineCytochrome P450 2A6enzyme
NicotineCytochrome P450 2E1enzyme
NicotineCytochrome P450 2A13enzyme
NicotineCytochrome P450 2B6enzyme
NicotineNeuronal acetylcholine receptor subunit beta-4target
NicotineNeuronal acetylcholine receptor subunit alpha-3target
NicotineNeuronal acetylcholine receptor subunit alpha-5target
NicotineNeuronal acetylcholine receptor subunit alpha-6target
NicotineNeuronal acetylcholine receptor subunit beta-3target
NicotineSolute carrier family 22 member 2transporter
NicotineSolute carrier family 22 member 1transporter
NicotineSolute carrier family 22 member 3transporter
NicotineSolute carrier family 22 member 5transporter
NicotineSolute carrier family 22 member 4transporter
NicotineCytochrome P450 1A1enzyme
NicotineCytochrome P450 1A2enzyme
NicotineCytochrome P450 2C19enzyme
NicotineCytochrome P450 2C8enzyme
NicotineCytochrome P450 2C9enzyme
NicotineCytochrome P450 2D6enzyme
NicotineCytochrome P450 3A4enzyme
NicotineAmine oxidase [flavin-containing] Aenzyme
NicotineAmine oxidase [flavin-containing] Benzyme
NicotineCytochrome P450 19A1target
NicotineCholine O-acetyltransferasetarget
BupropionSodium-dependent dopamine transportertarget
BupropionSodium-dependent noradrenaline transportertarget
BupropionCytochrome P450 2B6enzyme
BupropionCytochrome P450 2D6enzyme
BupropionAlpha-1-acid glycoprotein 1carrier
BupropionNeuronal acetylcholine receptor subunit alpha-3target
BupropionCytochrome P450 2C9enzyme
BupropionCytochrome P450 2E1enzyme
BupropionSolute carrier family 22 member 2transporter
Bupropion5-hydroxytryptamine receptor 3Atarget
VareniclineNeuronal acetylcholine receptor subunit alpha-4target
VareniclineNeuronal acetylcholine receptor subunit alpha-7target
VareniclineNeuronal acetylcholine receptor subunit alpha-3target
VareniclineNeuronal acetylcholine receptor subunit alpha-6target
VareniclineNeuronal acetylcholine receptor subunit beta-2target
VareniclineSolute carrier family 22 member 2transporter