Harringtonines

Name
Harringtonines
Accession Number
DBCAT005005
Description

Tetracyclic spiro-BENZAZEPINES isolated from the seeds of CEPHALOTAXUS. They are esters of the alkaloid cephalotaxine and may be effective as antineoplastic agents.

Drugs
DrugDrug Description
Omacetaxine mepesuccinateA cephalotaxine used in the treatment of Chronic Myeloid Leukemia (CML) that is intolerant to or resistant to two or more tyrosine kinase inhibitors.
Drugs & Drug Targets
DrugTargetType
Omacetaxine mepesuccinate50S ribosomal protein L2target
Omacetaxine mepesuccinate60S ribosomal protein L3target