Maytansine

Name
Maytansine
Accession Number
DBCAT005587
Description

An ansa macrolide isolated from the MAYTENUS genus of East African shrubs.

Drugs
DrugDrug Description
Trastuzumab emtansineAn antineoplastic agent and antibody-drug conjugate used to treat HER2-overexpressing breast cancer.
Lorvotuzumab mertansineLorvotuzumab mertansine has been used in trials studying the treatment of SCLC, Leukemia, Ovarian Cancer, Multiple Myeloma, and Merkel Cell Carcinoma, among others.
Drugs & Drug Targets
DrugTargetType
Trastuzumab emtansineReceptor tyrosine-protein kinase erbB-2target
Trastuzumab emtansineP-glycoprotein 1transporter
Trastuzumab emtansineCytochrome P450 3A4enzyme
Trastuzumab emtansineCytochrome P450 3A5enzyme
Lorvotuzumab mertansineCytochrome P450 3A4enzyme