Receptors, Cytoplasmic and Nuclear
- Name
- Receptors, Cytoplasmic and Nuclear
- Accession Number
- DBCAT005636
- Description
Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.
- Drugs
Drug Drug Description Brexucabtagene autoleucel A modified autologous chimeric antigen receptor (CAR) T cell therapy employing a modified murine anti-CD19 single-chain variable fragment linked to CD28 and CD3ΞΆ co-stimulatory domains for the treatment of patients with relapsed and refractory mantle cell lymphoma. Idecabtagene vicleucel An autologous T-cell therapy indicated to treat relapsed or refractory multiple myeloma. - Drugs & Drug Targets
Drug Target Type Brexucabtagene autoleucel B-lymphocyte antigen CD19 target Idecabtagene vicleucel Tumor necrosis factor receptor superfamily member 17 target