Receptors, Cytoplasmic and Nuclear

Name
Receptors, Cytoplasmic and Nuclear
Accession Number
DBCAT005636
Description

Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.

Drugs
DrugDrug Description
Brexucabtagene autoleucelA modified autologous chimeric antigen receptor (CAR) T cell therapy employing a modified murine anti-CD19 single-chain variable fragment linked to CD28 and CD3ΞΆ co-stimulatory domains for the treatment of patients with relapsed and refractory mantle cell lymphoma.
Idecabtagene vicleucelAn autologous T-cell therapy indicated to treat relapsed or refractory multiple myeloma.
Drugs & Drug Targets
DrugTargetType
Brexucabtagene autoleucelB-lymphocyte antigen CD19target
Idecabtagene vicleucelTumor necrosis factor receptor superfamily member 17target