Trop-2-Directed Monoclonal Antibodies

All categories
Name
Trop-2-Directed Monoclonal Antibodies
Accession Number
DBCAT005694
Description

Not Available

Drugs
DrugDrug Description
Sacituzumab govitecanSacituzumab govitecan targets TROP-2-expressing cancer cells through a humanized antibody (RS7) before subsequently becoming internalized and releasing the topoisomerase I inhibitor SN-38 to induce DNA damage-mediated apoptosis.
Drugs & Drug Targets
DrugTargetType
Sacituzumab govitecanTumor-associated calcium signal transducer 2target
Sacituzumab govitecanDNA topoisomerase 1target
Sacituzumab govitecanFar upstream element-binding protein 1target
Sacituzumab govitecanUDP-glucuronosyltransferase 1-1enzyme