Porphyria Cutanea Tarda (DBCOND0000759)

Identifiers

Synonyms

Cutanea porphyria tarda / Porphyria cutanea tarda / Cutaneous hepatic porphyria / Porphyria cutanea tarda (disorder) / Porphyria non-acute

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Chloroquine	An antimalarial drug used to treat susceptible infections with P. vivax, P. malariae, P. ovale, and P. falciparum. It is also used for second line treatment for rheumatoid arthritis.	Tumor necrosis factortarget Toll-like receptor 9target Glutathione S-transferase A2target Cytochrome P450 2D6enzyme Cytochrome P450 3A4enzyme Cytochrome P450 1A1enzyme Cytochrome P450 2C8enzyme Cytochrome P450 3A5enzyme Glutathione S-transferasetarget ATP-dependent translocase ABCB1transporter Albumincarrier alpha1-acid glycoproteincarrier High mobility group protein B1target Glutathione S-transferase Mu 1target Angiotensin-converting enzyme 2target Atypical chemokine receptor 1target
Hydroxychloroquine	An antimalarial medication used to treat uncomplicated cases of malaria and for chemoprophylaxis in specific regions. Also a disease modifying anti-rheumatic drug (DMARD) indicated for treatment of rheumatoid arthritis and lupus erythematosus.	DNAtarget Toll-like receptor 7target Toll-like receptor 9target Cytochrome P450 2D6enzyme ATP-dependent translocase ABCB1transporter Albumincarrier alpha1-acid glycoproteincarrier Cytochrome P450 3A4enzyme Solute carrier organic anion transporter family member 1A2transporter Angiotensin-converting enzyme 2target Cytochrome P450 2C8enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00005103	Study of the Pathogenesis of Porphyria Cutanea Tarda	No drug interventions	Not Available	Not Available	completed
NCT01284946	Safety and Efficacy of Oral Deferasirox in Patients With Porphyria Cutanea Tarda	Deferasirox	treatment	2	unknown_status
NCT01573754	Hydroxychloroquine and Phlebotomy for Treating Porphyria Cutanea Tarda	Hydroxychloroquine	treatment	2	completed
NCT00599326	Pilot Trial of Deferasirox in the Treatment of Porphyria Cutanea Tarda	Deferasirox	treatment	3	completed
NCT03118674	Harvoni Treatment Porphyria Cutanea Tarda	Ledipasvir Sofosbuvir	treatment	2	completed
NCT00213772	Risk Factors of Porphyria Cutanea Tarda (PCT)	No drug interventions	Not Available	Not Available	completed