Skin hyperpigmentation (DBCOND0019868)

Identifiers

Synonyms

Skin hyper-pigmentation / Increased skin pigmentation / Hyperpigmentation / Hyperpigmentation skin / Hyperpigmentation disorder / (Dyschromia) or (hyperpigmentation) or (pigmentation disorders) / Hyperpigmentation of skin (disorder) / Hyperpigmentation (morphologic abnormality) / Hyperpigmentation disorders / Hypermelanosis

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Hydroquinone	A topical brightening agent used for the treatment of skin disorders associated with hyperpigmentation including melasma, post-inflammatory hyperpigmentation, sunspots, and freckles.	Tyrosinasetarget Albumincarrier Lysosomal alpha-glucosidaseenzyme Cysteinyl leukotriene receptor 1target Integrin alpha-IIbtarget Integrin beta-3target
Tretinoin	A vitamin A derivative used to treat acne vulgaris and certain types of promyelocytic leukemia, as well as various skin conditions in over-the-counter medications.	Retinoic acid receptor gammatarget Retinoic acid receptor RXR-betatarget Aldehyde dehydrogenase 1A1target Retinoic acid-induced protein 3target Retinoic acid receptor RXR-gammatarget Retinal dehydrogenase 2target Retinoic acid receptor responder protein 1target Cytochrome P450 2C8enzyme Cellular retinoic acid-binding protein 1transporter Cellular retinoic acid-binding protein 2transporter Cytochrome P450 2B6enzyme Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 2A6enzyme Cytochrome P450 3A7enzyme Cytochrome P450 2C18enzyme Cytochrome P450 2C9enzyme Cytochrome P450 4A11enzyme Cytochrome P450 1A1enzyme Retinoic acid receptor alphatarget Retinoic acid receptor betatarget Lipocalin-1target Odorant-binding protein 2atarget Retinol-binding protein 4target Albumincarrier [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrialtarget Retinoic acid receptor RXR-alphatarget Carcinoembryonic antigentarget UDP-glucuronosyltransferase 2B7enzyme Cytochrome P450 2E1enzyme Cytochrome P450 26A1enzyme Cellular retinoic acid-binding protein 1target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT06189105	Efficacy and Safety Assessment of Niacinamide Cosmetic Preparation: a Randomized Controlled Trial	No drug interventions	treatment	Not Available	recruiting
NCT04998578	Comparison Of Aesthetic Techniques For Rejuvenation Of Genital Region: A Randomized Clinical Trial	No drug interventions	treatment	Not Available	recruiting
NCT02947022	Effects of IV-Administered Ca-DTPA and Zn-DTPA To Treat Patients With Gadolinium Deposition Disease	Pentetic acid Zinc	treatment	1 / 2	terminated