severe Rheumatoid arthritis (DBCOND0020317)

Identifiers

Synonyms

Severe Rheumatoid Arthritis

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Certolizumab pegol	A tumor necrosis factor (TNF) blocker used to treat a variety of autoimmune and autoinflammatory conditions like Crohn's disease, rheumatoid arthritis, active psoriatic arthritis, ankylosing spondylitis, axial spondyloarthritis, and plaque psoriasis.	Tumor necrosis factortarget Aldo-keto reductase family 1 member A1enzyme
Penicillamine	A chelator used to treat Wilson's disease, cystinuria, and rheumatoid arthritis.	Solute carrier organic anion transporter family member 1B1transporter Coppertarget
Tofacitinib	A Janus kinase (JAK) inhibitor used to treat rheumatic conditions, such as rheumatoid arthritis and ankylosing spondylitis, and ulcerative colitis.	Non-receptor tyrosine-protein kinase TYK2target Cytochrome P450 3A4enzyme Cytochrome P450 2C19enzyme Tyrosine-protein kinase JAK2target Tyrosine-protein kinase JAK1target Tyrosine-protein kinase JAK3target Albumincarrier

Clinical Trials

Not Available