NYHA Functional Class II-III Pulmonary arterial hypertension (DBCOND0020679)

Identifiers

Synonyms

Not Available

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Sildenafil	A phosphodiesterase inhibitor used for the treatment of erectile dysfunction.	cGMP-specific 3',5'-cyclic phosphodiesterasetarget Cytochrome P450 2C9enzyme Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammatarget Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gammatarget Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-binding cassette sub-family C member 4transporter ATP-binding cassette sub-family C member 5transporter ATP-binding cassette sub-family C member 10transporter Cytochrome P450 2C19enzyme Cytochrome P450 2D6enzyme Cytochrome P450 2E1enzyme Solute carrier organic anion transporter family member 1B1transporter ATP-dependent translocase ABCB1transporter Ornithine decarboxylasetarget Programmed cell death 1 ligand 1target Plasma protease C1 inhibitortarget

Clinical Trials

Not Available