Extrapyramidal disorder caused by neuroleptic drugs without Tardive dyskinesia (DBCOND0020744)

Identifiers

Synonyms

Drug-induced Extrapyramidal Side Effects / Drug-induced extra-pyramidal symptoms / Unspecified extrapyramidal disease (disorder) / (Extrapyramidal disease NOS) or (blepharospasm) or (choreo-athetosis) or (writer's cramp - organic) or (myoclonic jerks) or (spasmodic torticollis) / Syndrome extrapyramidal / Extrapyramidal syndrome (NOS) / Extrapyramidal disorder (NOS) / Extrapyramidal syndrome / Extrapyramidal disorder / Extrapyramidal Disorders / Extrapyramidal disease (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Amantadine	A medication used to treat dyskinesia in Parkinson's patients receiving levodopa, as well as extrapyramidal side effects of medications.	D(2) dopamine receptortarget Matrix protein 2target Aromatic-L-amino-acid decarboxylaseenzyme Amine oxidase [flavin-containing] Benzyme Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter Glutamate receptor ionotropic, NMDA 3Atarget Neuronal acetylcholine receptor subunit alpha-7target Neuronal acetylcholine receptor subunit alpha-4target Neuronal acetylcholine receptor subunit alpha-3target
Biperiden	A muscarinic receptor antagonist used to treat parkinsonism and control extrapyramidal side effects of neuroleptic drugs.	Muscarinic acetylcholine receptor M1target Cytochrome P450 2D6enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT02366897	Extrapyramidal Side-Effects in Antipsychotic Drug Therapeutics	No drug interventions	other	Not Available	completed