Primary generalized tonic-clonic seizures (DBCOND0021691)

Identifiers

Synonyms

Primary Generalized tonic-clonic seizure / Seizures, Tonic-Clonic / Generalised tonic-clonic seizure / Generalized Tonic Clonic Seizures / Seizure grand mal / Generalized tonic clonic seizure / Generalised tonic-clonic seizures / Tonic-clonic Seizure / Grand mal Seizures / Centrencephalic epilepsies / Generalized tonic-clonic Seizure / Grand mal Generalized tonic-clonic seizure / Generalized Tonic-Clonic Seizures / Grand mal seizure / Grand mal epileptic seizure / Primary Generalized Tonic-Clonic Seizures / Tonic-clonic seizures / Centrencephalic epilepsy / Other generalized epilepsy and epileptic syndromes / Generalised onset motor seizure / Generalized onset motor seizure / Grand mal seizure (finding) / Tonic-clonic seizure (finding) / Grand mal fit / Grand mal epileptic fit / Centrencephalic epilepsy (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Lacosamide	An antiepileptic drug used to treat partial-onset seizures and primary generalized tonic-clonic seizures.	Sodium channel protein type 9 subunit alphatarget Sodium channel protein type 3 subunit alphatarget Sodium channel protein type 10 subunit alphatarget Cytochrome P450 2C19enzyme Cytochrome P450 2C9enzyme Cytochrome P450 3A4enzyme Dihydropyrimidinase-related protein 2target Sodium channel protein type 11 subunit alphatarget
Lamotrigine	A phenyltriazine antiepileptic used to treat some types of epilepsy and bipolar I disorder.	Voltage-gated sodium channel alpha subunittarget UDP-glucuronosyltransferases (UGTs)enzyme ATP-dependent translocase ABCB1transporter Dihydrofolate reductaseenzyme 5-hydroxytryptamine receptor 3Atarget Voltage-dependent R-type calcium channel subunit alpha-1Etarget Adenosine receptor A1target Adenosine receptor A2atarget Alpha-1A adrenergic receptortarget Alpha-2A adrenergic receptortarget Beta-1 adrenergic receptortarget D(1) dopamine receptortarget D(2) dopamine receptortarget GABA(A) Receptortarget GABA(A) Receptor Benzodiazepine Binding Sitetarget Histamine H1 receptortarget Kappa-type opioid receptortarget Acetylcholine receptor subunit alphatarget 5-hydroxytryptamine receptor 2Atarget Solute carrier family 22 member 2transporter Albumincarrier Solute carrier family 22 member 1transporter Glutamate receptor 1target Sodium channel protein type 11 subunit alphatarget
Levetiracetam	A novel anticonvulsant agent used as an adjunct medication to manage partial onset, myoclonic, and generalized tonic-clonic seizures in patients with epilepsy.	Synaptic vesicle glycoprotein 2Atarget ATP-dependent translocase ABCB1transporter Voltage-dependent N-type calcium channel subunit alpha-1Btarget 5-hydroxytryptamine receptor 3Atarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05667142	A Study to Evaluate XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures	No drug interventions	treatment	3	recruiting
NCT02736162	Study to Investigate Dosage, Efficacy, and Safety of Perampanel Given as Monotherapy in Patients With Epilepsy	No drug interventions	Not Available	Not Available	completed
NCT03059329	Investigation of the Clinical Safety and Efficacy of Long-term Treatment With Fycompa Tablets in Adult Epilepsy Patients With Partial-onset Seizures (With or Without Secondary Generalized Seizures) or Primary Generalized Tonic-clonic Seizures	Perampanel	Not Available	Not Available	completed
NCT03059381	Investigation of the Clinical Safety and Efficacy of Long-term Treatment With Fycompa Tablets in Adolescence Epilepsy Patients With Partial-onset Seizures (With or Without Secondary Generalized Seizures) or Primary Generalized Tonic-clonic Seizures	Perampanel	Not Available	Not Available	completed
NCT03288129	Study to Evaluate the Efficacy and Safety of Perampanel as Monotherapy or First Adjunctive Therapy in Subjects With Partial Onset Seizures With or Without Secondarily Generalized Seizures or With Primary Generalized Tonic-Clonic Seizures	Perampanel	treatment	4	completed