refractory, advanced Breast cancer (DBCOND0023190)

Identifiers

Synonyms

Refractory advanced Breast cancer / Refractory, advanced Breast Cancer

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Everolimus	A mammalian target of rapamycin (mTOR) kinase inhibitor used to treat various types of malignancies.	Serine/threonine-protein kinase mTORtarget Cytochrome P450 3A4enzyme Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter Solute carrier organic anion transporter family member 1A2transporter Cytochrome P450 2D6enzyme ATP-dependent translocase ABCB1transporter
Exemestane	An aromatase inhibitor used to treat breast cancer in postmenopausal women after treatment with tamoxifen.	Aromatasetarget Cytochrome P450 3A4enzyme Aromataseenzyme
Lapatinib	An antineoplastic agent and tyrosine kinase inhibitor used for the treatment of advanced or metastatic HER-positive breast cancer in patients who received prior chemotherapeutic treatments.	Epidermal growth factor receptortarget Receptor tyrosine-protein kinase erbB-2target Cytochrome P450 3A4enzyme Cytochrome P450 2C8enzyme ATP-dependent translocase ABCB1transporter Antigen peptide transporter 1transporter Cytochrome P450 3A5enzyme Cytochrome P450 2C19enzyme Eukaryotic elongation factor 2 kinasetarget
Palbociclib	An endocrine-based chemotherapeutic agent used in combination with other antineoplastic agents to treat HER2-negative and HR-positive advanced or metastatic breast cancer.	Cyclin-dependent kinase 4target Cyclin-dependent kinase 6target Cytochrome P450 3A4enzyme Sulfotransferase 2A1enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Albumincarrier Solute carrier family 22 member 1transporter

Clinical Trials

Not Available