Other and unspecified effects of high altitude (DBCOND0024755)

Identifiers

Synonyms

Acute Mountain Sickness (AMS) / Mountain sickness acute / High Altitude / Acute Mountain Sickness / Acute mountain sickness (disorder) / High altitude (physical force) / Hypobarism

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Acetazolamide	A carbonic anhydrase inhibitor used to treat edema from heart failure or medications, certain types of epilepsy, and glaucoma.	Carbonic anhydrase 1target Aquaporin-1target Carbonic anhydrase 14target Solute carrier family 22 member 6transporter Carbonic anhydrase 2target Carbonic anhydrase 3target Carbonic anhydrase 4target Cytochrome P450 3A4enzyme Carbonic anhydrase 7target Carbonic anhydrase 12target
Nifedipine	A dihydropyridine calcium channel blocker indicated for the management of several subtypes of angina pectoris, and hypertension.	Cytochrome P450 3A4enzyme Cytochrome P450 2E1enzyme Cytochrome P450 2D6enzyme Voltage-dependent L-type calcium channel subunit alpha-1Dtarget Voltage-dependent L-type calcium channel subunit alpha-1Starget Voltage-dependent L-type calcium channel subunit alpha-1Ctarget Voltage-dependent L-type calcium channel subunit beta-2target A-type voltage-gated potassium channel KCND3target Voltage-dependent T-type calcium channeltarget Cytochrome P450 1A2enzyme Cytochrome P450 2A6enzyme Cytochrome P450 2C8enzyme ATP-binding cassette sub-family C member 3transporter ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 2transporter Cytochrome P450 1A1enzyme Cytochrome P450 2B6enzyme Nuclear receptor subfamily 1 group I member 2target Solute carrier organic anion transporter family member 1B1transporter Bile salt export pumptransporter Cytochrome P450 2C9enzyme Albumincarrier alpha1-acid glycoproteincarrier Cytochrome P450 3A5enzyme Calmodulintarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01682551	Evaluation of the Prevention and Treatment Effects of Chinese Medicine on High Altitude Illness	No drug interventions	prevention	2	unknown_status
NCT04993729	Safety and Efficacy of T89 in the Prevention and Treatment of Adults With Acute Mountain Sickness (AMS)	No drug interventions	treatment	3	completed
NCT03552263	Safety and Efficacy of T89 in Prevention and Treatment of Adults With Acute Mountain Sickness (AMS)	No drug interventions	treatment	2	completed
NCT03530163	Breathing Training to Improve Human Performance at High Altitude	No drug interventions	prevention	Not Available	completed
NCT06638658	Postoperative Complications of Orthopedic Surgery in Patients From High-altitude Regions	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT05474287	SJOV vs. HFNO for Hypoxia During Procedural Sedation at High Altitudes	No drug interventions	prevention	Not Available	recruiting
NCT06557928	Protocol for Evaluating Physiological and Psychological Adaptation Mechanisms in Tibetan Plateau Environments	No drug interventions	Not Available	Not Available	enrolling_by_invitation
NCT04915378	Hypoxia-altitude Testing to Predict Altitude Related Adverse Health Effects in Chronic Obstructive Pulmonary Disease (COPD) Patients	No drug interventions	Not Available	Not Available	completed
NCT01830530	HIGH Altitude CArdiovascular REsearch in the ANDES	Nifedipine Telmisartan	treatment	4	completed
NCT02233582	Effects of Non-steroidal Anti-inflammatory Drugs (NSAIDS) on Acclimatization to High Altitude	Ibuprofen	basic_science	1	completed
NCT06152744	Evaluation of Membrane Lung Function in High-altitude Regions	No drug interventions	Not Available	Not Available	recruiting
NCT03851744	High Altitude and Exogenous Carbohydrate Oxidation	No drug interventions	basic_science	Not Available	completed
NCT04199650	Definition of ARDS in Qinghai Province: Verification of Berlin Definition Plateau Criteria	No drug interventions	Not Available	Not Available	unknown_status
NCT05304923	Supraglottic Jet Oxygenation and Ventilation for Gastrointestinal Endoscopy at High-altitude	No drug interventions	prevention	Not Available	unknown_status
NCT05063643	Cardiotoxicity of Targeted Therapy for HER-2 Positive Breast Cancer Patients at High Altitude	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT05115721	Establishing the Reference Interval for Pulse Oxygen Saturation in Neonates at High Altitude	No drug interventions	Not Available	Not Available	unknown_status
NCT06393998	CO2 Supplement for Treatment of Acute Mountain Sickness	No drug interventions	treatment	Not Available	recruiting
NCT06498505	HighCycle: Effect of Acetazolamide on Pulmonary Artery Pressure in Women Compared to Men	Acetazolamide	prevention	4	recruiting
NCT04604249	Prevalence of COVID-19 in High Altitude : Insights From the Highest City of the World	No drug interventions	Not Available	Not Available	unknown_status
NCT05798416	Effect of Inhalation of Low Dose CO2 on Exercise Performance at High Altitude	No drug interventions	treatment	Not Available	completed
NCT06133530	Human Milk Oligosaccharides (HMOs) and Gut Microbiota, Immune System in Antarctica	No drug interventions	treatment	Not Available	enrolling_by_invitation
NCT06164665	Effects of Pioglitazone on Exogenous Carbohydrate Oxidation During Steady-State Exercise at High Altitude	Pioglitazone	treatment	4	completed
NCT06392373	High Altitude Muscle Recovery	No drug interventions	treatment	Not Available	completed
NCT06446427	The Effect of Acute High Altitude Exposure on Rescuer Performance and Patient Care	No drug interventions	health_services_research	Not Available	not_yet_recruiting
NCT05715476	The Effect of Different Altitude Levels on Spinal Anesthesia in Cesarean Section Surgery	No drug interventions	supportive_care	Not Available	completed
NCT04290481	Oxygen Saturation and Perfusion Index ın Neonates at High Altitude	No drug interventions	Not Available	Not Available	completed
NCT06450899	Prochlorperazine Maleate Versus Placebo for the Prophylaxis of Acute Mountain Sickness	Prochlorperazine	prevention	2	completed
NCT00326703	Effects of Aircraft Cabin Altitude on Passenger Comfort and Discomfort	No drug interventions	Not Available	Not Available	completed
NCT03270787	Study of Compound Danshen Dripping Pills to Treat Acute Mountain Sickness	No drug interventions	treatment	1 / 2	completed
NCT01436383	Oxidative Stress in Hypobaric Hypoxia	No drug interventions	basic_science	Not Available	completed
NCT00559832	Prevention of Acute Mountain Sickness by Intermittent Hypoxia	No drug interventions	prevention	Not Available	completed
NCT01842906	Study Looking at End Expiratory Pressure for Altitude Illness Decrease (SLEEP-AID)	No drug interventions	prevention	Not Available	completed
NCT06145113	The Effect of Continuous Positive Pressure Ventilation on Symptoms of Acute Mountain Sickness	No drug interventions	treatment	Not Available	not_yet_recruiting
NCT05734716	Colorado-Oregon Altitude Study	Erythropoietin Iron Iron sucrose Sodium chloride	basic_science	4	completed
NCT02811016	Inhaled Budesonide and Acute Mountain Sickness	Budesonide	prevention	1	completed
NCT01902758	Drug Combination on Exercise Performance at High Altitude	Ambrisentan Theophylline	Not Available	2 / 3	completed
NCT03390335	Decompression Tables for Diving at Altitude	No drug interventions	prevention	Not Available	completed
NCT04111263	Gut-microbiota Targeted Nutritional Intervention for Gut Barrier Integrity at High Altitude	No drug interventions	prevention	Not Available	completed
NCT00603122	Acclimatization Mechanisms During Ascent to 7500m	No drug interventions	prevention	Not Available	completed
NCT01418157	A Trial of Acetazolamide Versus Placebo in Preventing Mountain Sickness During Rapid Ascent	Acetazolamide	Not Available	4	completed
NCT03424226	Sickness Evaluation at Altitude With Acetazolamide at Relative Dosages	Acetazolamide	prevention	1	completed
NCT01522326	Comparison of Metoclopramide and Ibuprofen for the Treatment of Acute Mountain Sickness	Ibuprofen Metoclopramide	treatment	Not Available	completed
NCT03828474	Sickness Evaluation at Altitude With Acetazolamide at Relative Doses	Acetazolamide	prevention	1	completed
NCT02604173	Altitude Sickness Prevention and Efficacy of Comparative Treatments	Acetazolamide Budesonide	prevention	3	completed
NCT06499727	HighCycle Study: Effect of Acetazolamide on Acute Mountain Sickness in Women Compared to Men	Acetazolamide	prevention	4	recruiting
NCT06499714	HighCycle Study: Effect of High Altitude on Acute Mountain Sickness in Women Related to Their Menstrual Cycle Phase	No drug interventions	Not Available	Not Available	recruiting
NCT05733338	The Effects of Intermittent Hypoxia on Acute Hypoxic Injury	No drug interventions	prevention	Not Available	recruiting
NCT01565603	Sleep and Cerebral Responses to High Altitude	No drug interventions	Not Available	Not Available	unknown_status
NCT03154645	Altitude Sickness Prevention With Ibuprofen Relative to Acetazolamide and Treatment Efficacy	Acetazolamide Ibuprofen	prevention	1	completed
NCT06531161	EleVation carE: a Randomized Controlled Trial on the Prevention of Acute Mountain Sickness With Suxiao Jiuxin Pill	No drug interventions	prevention	2 / 3	not_yet_recruiting
NCT01536288	Can Rhodiola Crenulata Intake Improve Oxygen Saturation and Decrease the Incidence of Acute Mountain Sickness	No drug interventions	prevention	2	completed
NCT06039475	Risk Factors Associated With High Altitude Sickness: A Case-Control Study	No drug interventions	Not Available	Not Available	completed
NCT03561675	Effect of Acetazolamide on Acute Mountain Sickness in Lowlanders Older Than 40 Years	Acetazolamide	prevention	4	completed
NCT06310642	Efficacy of Prophylactic Treatment of Oral Prochlorperazine for Acute Mountain Sickness	Diphenhydramine Prochlorperazine	treatment	4	completed
NCT01698619	Hemodynamic Changes in Altitude Adaptation	No drug interventions	Not Available	Not Available	unknown_status
NCT05023941	Optimization Strategy for the Prevention of AMS by RIPC Combined With Acetazolamide	Acetazolamide	prevention	4	completed
NCT01794130	The Incidence of Subclinical High-altitude Pulmonary Oedema at High Altitude	No drug interventions	Not Available	Not Available	completed
NCT00627965	Randomized, Controlled Trial of Regular Sildenafil Citrate in the Prevention of Altitude Illness	Sildenafil	prevention	4	completed
NCT01468194	Change in Peripheral Oxygen Saturation by Using Different Breathing Procedures in High Altitude	No drug interventions	prevention	Not Available	completed
NCT00664001	Anti-Oxidant Supplementation for the Prevention of Acute Mountain Sickness	No drug interventions	prevention	3	completed
NCT03956472	Alternative Treatments in Acute Mountain Sickness	No drug interventions	prevention	Not Available	terminated
NCT00886912	Training in Hypoxia to Prevent Acute Mountain Sickness	No drug interventions	prevention	Not Available	unknown_status
NCT01665781	Erythropoietin in the Prevention of Acute Mountain Sickness	Erythropoietin	prevention	4	completed
NCT03621410	T89 in Prevention and Treatment of Acute Mountain Sickness (AMS) During Rapid Ascent	No drug interventions	treatment	2	recruiting