locally advanced Squamous cell carcinoma of head and neck (DBCOND0025497)

Identifiers

Synonyms

Locally Advanced Head and Neck Squamous Cell Carcinoma / Locally advanced Squamous Cell Carcinoma of Head and Neck

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Docetaxel	A taxoid antineoplastic agent used in the treatment of various cancers, such as locally advanced or metastatic breast cancer, metastatic prostate cancer, gastric adenocarcinoma, and head and neck cancer.	Apoptosis regulator Bcl-2target Tubulin beta-1 chaintarget Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 10transporter Cytochrome P450 1B1enzyme Microtubule-associated protein 2target Microtubule-associated protein 4target Microtubule-associated protein tautarget Solute carrier organic anion transporter family member 1B3transporter Solute carrier family 22 member 7transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter ATP-binding cassette sub-family C member 2transporter Multidrug resistance-associated protein 1transporter Nuclear receptor subfamily 1 group I member 2target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04454489	Quad Shot Radiotherapy in Combination With Immune Checkpoint Inhibition	Pembrolizumab	treatment	2	active_not_recruiting
NCT05172245	Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck Cancer	Chloride ion Cisplatin Ipatasertib Platinum	treatment	1	recruiting
NCT06129864	A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy	Volrustomig	treatment	3	recruiting
NCT04949503	A Real-world Study of the Efficacy and Safety of Nimotuzumab in Combination With Chemoradiotherapy for LASCCHN	Nimotuzumab	Not Available	Not Available	completed
NCT03875053	Home Sleep Apnea Machine in Evaluating Obstructive Sleep Apnea in Patients With Stage III-IV Head and Neck Cancer	No drug interventions	diagnostic	Not Available	withdrawn
NCT05743270	Study of RP3 in Combination With Nivolumab and Other Therapy in Patients With Locoregionally Advanced or Recurrent SCCHN	Nivolumab	treatment	2	withdrawn
NCT04947241	Toripalimab Combined With Gemcitabine and Cisplatin Treating Resectable Locally Advanced HNSCC	Cisplatin Gemcitabine Toripalimab	treatment	1	recruiting
NCT06470217	A Prospective, Randomised Controlled, Phase II Clinical Study of Tirilizumab in Combination With Albumin-bound Paclitaxel With Cisplatin for Neoadjuvant and Adjuvant Treatment of Locally Advanced Resectable Oral Squamous Cell Carcinoma	Albumin human Cisplatin Paclitaxel	treatment	2	recruiting
NCT03649048	Low-Dose Weekly vs High-Dose Cisplatin	Cisplatin	supportive_care	Not Available	recruiting
NCT05861557	Neoadjuvant Radiotherapy Combined With Toripalimab for Locally Advanced Head and Neck Squamous Cell Carcinoma	Toripalimab	treatment	2	not_yet_recruiting
NCT05527782	Induction Modified TPF Followed by Concurrent Chemoradiotherapy in Locally Advanced Squamous Cell Carcinoma of the Head and Neck	No drug interventions	treatment	2	recruiting
NCT06240689	A Prospective Randomized Controlled Study of Immune Checkpoint Maintenance Therapy After Radiotherapy and Chemotherapy for Locally Advanced Head and Neck Tumors Based on Peripheral Blood CD8Tex Detection in Peripheral Blood	Sintilimab Sodium chloride	treatment	2	recruiting
NCT03196869	the Study of Effect of Chronomodulated Chemotherapy on the Dendritic Cells Subsets in the Treatment of Advanced Nasopharyngeal Cancer	Cisplatin	treatment	2	unknown_status
NCT05269381	Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors	Cyclophosphamide Pembrolizumab Sargramostim	treatment	1 / 2	recruiting
NCT04541355	Sodium Thiosulfate in Preventing Ototoxicity for Squamous Cell Cancer Patients Undergoing Chemoradiation With Cisplatin	Cisplatin Platinum Thiosulfuric acid	supportive_care	2	completed
NCT05724602	Radiotherapy Plus Xevinapant in Older Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma	Xevinapant	treatment	2	suspended
NCT05773079	Toripalimab Maintenance for Locally Advanced Head and Neck Squamous Cell Carcinoma	Toripalimab	treatment	2	not_yet_recruiting
NCT05376553	Study of Cemiplimab - TP Induction Chemotherapy in Patients With Locally Advanced Squamous Cell Carcinoma of the Head and Neck	Cemiplimab Cisplatin Docetaxel	treatment	1	recruiting
NCT03426657	Radiotherapy With Double Checkpoint Blockade of Locally Advanced HNSCC	Durvalumab Tremelimumab	treatment	2	completed
NCT03117257	Docetaxel and Loplatin Induction Chemotherapy Followed by Concurrent Chemoradiotherapy for Locally Advanced SCCHN	Cisplatin Lobaplatin Platinum	treatment	2	unknown_status
NCT05245682	Tolinapant and Radiation for Cisplatin-Ineligible, Previously Untreated, Locally Advanced Head and Neck Cancer	Tolinapant	treatment	0	recruiting
NCT04892173	NBTXR3 With or Without Cetuximab in LA-HNSCC	Cetuximab Hafnium oxide	treatment	3	recruiting
NCT01689194	Efficacy Study of Genexol-PM and Cisplatin in Locally Advanced Head and Neck Cancer	Cisplatin	treatment	2	completed
NCT05872880	TPExtreme Induced Chemotherapy Followed by Surgery and Radiotherapy in the Oral Carcinoma.	No drug interventions	Not Available	Not Available	recruiting
NCT04870840	Image-guided Proton Therapy for the Treatment of Locally Advanced Unresectable Head and Neck Cancer	No drug interventions	treatment	1	completed
NCT04733495	Group-Mediated Cognitive Behavioral Resistance Exercise Intervention in Head and Neck Cancer Patients Undergoing Chemoradiation Treatment	No drug interventions	supportive_care	Not Available	active_not_recruiting
NCT06572514	De-escalation Radiation Strategy After NAC in Combination With ICI in LAHNSCC	Albumin human Cisplatin Paclitaxel Pembrolizumab	treatment	1 / 2	recruiting