refractory, metastatic hormone-refractory Prostate cancer (DBCOND0025647)

Identifiers

Synonyms

Hormone-refractory prostate cancer metastatic / Metastatic Hormone Refractory Prostate Cancer / Refractory, metastatic Hormone-Refractory Prostate Cancer / Metastasis from hormone-refractory prostate cancer (disorder) / Castration-resistant prostate cancer / Hormone-refractory prostate cancer / Hormone refractory prostate cancer (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Cabazitaxel	An antineoplastic agent used in combination with corticosteroids to treat metastatic castration-resistant prostate cancer in patients previously treated with a docetaxel-containing treatment regimen.	Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 2C8enzyme ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Tubulin beta-1 chaintarget Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter Albumincarrier Low-density lipoprotein receptorcarrier Very low-density lipoprotein receptorcarrier Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1carrier
Docetaxel	A taxoid antineoplastic agent used in the treatment of various cancers, such as locally advanced or metastatic breast cancer, metastatic prostate cancer, gastric adenocarcinoma, and head and neck cancer.	Apoptosis regulator Bcl-2target Tubulin beta-1 chaintarget Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme ATP-dependent translocase ABCB1transporter ATP-binding cassette sub-family C member 10transporter Cytochrome P450 1B1enzyme Microtubule-associated protein 2target Microtubule-associated protein 4target Microtubule-associated protein tautarget Solute carrier organic anion transporter family member 1B3transporter Solute carrier family 22 member 7transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter ATP-binding cassette sub-family C member 2transporter Multidrug resistance-associated protein 1transporter Nuclear receptor subfamily 1 group I member 2target

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00636090	Molecular, Genetic, and Genomic Assessments From Patients Treated With RAD001	No drug interventions	Not Available	Not Available	completed
NCT00411528	Efficacy and Safety of Patupilone in Men (≥18 Years) With Metastatic Hormone Refractory Prostate Cancer	Docetaxel Patupilone Prednisone	treatment	2	completed
NCT00766324	PHA-739358 for Treatment of Hormone Refractory Prostate Cancer	No drug interventions	treatment	2	completed
NCT04477512	Cabozantinib and Abiraterone With Checkpoint Inhibitor Immunotherapy in Metastatic Hormone Sensitive Prostate Cancer (CABIOS Trial)	Abiraterone Cabozantinib Nivolumab Prednisone	treatment	1	active_not_recruiting