Refractory Anemia (DBCOND0028565)

Identifiers

Synonyms

Refractory anemia / Anemia, Refractory / Anaemia refractory / Refractory anaemia / Anemia refractory / Myelodysplastic neoplasm with low blasts (morphologic abnormality) / Myelodysplastic syndrome with low blasts (disorder) / Myelodysplastic syndrome with single lineage dysplasia / Refractory cytopenia with unilineage dysplasia

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Azacitidine	A pyrimidine nucleoside analogue used to treat certain subtypes of myelodysplastic syndrome.	DNA (cytosine-5)-methyltransferase 1target Cytidine deaminaseenzyme DNAtarget RNAtarget
Cedazuridine	A cytidine deaminase inhibitor coadministered with the hypomethylating agent decitabine for the treatment of variable forms of myelodysplastic syndrome (MDS).	Cytidine deaminasetarget
Decitabine	A chemotherapeutic pyrimidine nucleoside analogue used for the treatment of myelodysplastic syndromes (MDS) by inducing DNA hypomethylation and corresponding alterations in gene expression.	DNAtarget DNA (cytosine-5)-methyltransferase 1target Deoxycytidine kinaseenzyme UMP-CMP kinaseenzyme Nucleoside diphosphokinaseenzyme Cytidine deaminaseenzyme DNA (cytosine-5)-methyltransferase 3Atarget DNA (cytosine-5)-methyltransferase 3Btarget Sodium/nucleoside cotransporter 1transporter Histone deacetylasetarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00015990	Thalidomide in Treating Patients With Myelodysplastic Syndrome	No drug interventions	treatment	2	completed
NCT00005845	Tipifarnib in Treating Patients With Myelodysplastic Syndromes	No drug interventions	treatment	1	completed
NCT00002798	Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome	No drug interventions	treatment	3	completed
NCT00719888	Umbilical Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With Hematologic Disease	Cyclophosphamide Cyclosporine Fludarabine Mycophenolate mofetil Thiotepa	treatment	2	active_not_recruiting
NCT00309842	Myeloablative Umbilical Cord Blood Transplantation in Hematological Diseases	No drug interventions	treatment	2	completed
NCT01384513	A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Malignancies	Busulfan Cyclophosphamide Fludarabine Mycophenolate mofetil Tacrolimus	treatment	2	completed
NCT00397813	Fludarabine Phosphate and Total Body Irradiation Followed by a Donor Peripheral Stem Cell Transplant in Treating Patients With Myelodysplastic Syndromes or Myeloproliferative Disorders	No drug interventions	treatment	2	completed
NCT03358719	DEC-205/NY-ESO-1 Fusion Protein CDX-1401, Poly ICLC, Decitabine, and Nivolumab in Treating Patients With Myelodysplastic Syndrome or Acute Myeloid Leukemia	Cancer/testis antigen 1 Carboxymethylcellulose Decitabine Hiltonol Lysine Nivolumab Polyinosinic-polycytidylic acid Rasdegafusp alfa	treatment	1	completed
NCT01165996	Differentiation Therapy With Decitabine in Treating Patients With Myelodysplastic Syndrome	2'-Deoxycytidine Decitabine	treatment	1 / 2	completed
NCT00078858	Mycophenolate Mofetil and Cyclosporine in Reducing Graft-Versus-Host Disease in Patients With Hematologic Malignancies or Metastatic Kidney Cancer Undergoing Donor Stem Cell Transplant	No drug interventions	treatment	1 / 2	completed
NCT03314974	Myeloablative Allo HSCT With Related or Unrelated Donor for Heme Disorders	No drug interventions	treatment	2	recruiting
NCT00027820	Total-Body Irradiation and Fludarabine Phosphate Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies or Kidney Cancer	No drug interventions	treatment	1 / 2	completed
NCT00104962	Lenalidomide in Treating Young Patients With Relapsed or Refractory Solid Tumors or Myelodysplastic Syndromes	No drug interventions	treatment	1	completed
NCT01146210	Identification of de Novo Fanconi Anemia in Younger Patients With Newly Diagnosed Acute Myeloid Leukemia	No drug interventions	Not Available	Not Available	completed
NCT00275184	Bowel Preparation and Prokinetics in Capsule Endoscopy	No drug interventions	diagnostic	3	unknown_status
NCT00392353	Vorinostat and Azacitidine in Treating Patients With Myelodysplastic Syndromes or Acute Myeloid Leukemia	No drug interventions	treatment	1 / 2	active_not_recruiting
NCT00343798	A Pilot Study to Evaluate the Co-Infusion of Ex Vivo Expanded Cord Blood Cells With an Unmanipulated Cord Blood Unit in Patients Undergoing Cord Blood Transplant for Hematologic Malignancies	No drug interventions	treatment	1	completed
NCT00462605	MS-275 and GM-CSF in Treating Patients With Myelodysplastic Syndrome and/or Relapsed or Refractory Acute Myeloid Leukemia or Acute Lymphocytic Leukemia	No drug interventions	treatment	2	completed
NCT01175785	Infusion of Off-the-Shelf Expanded Cord Blood Cells to Augment Cord Blood Transplant in Patients With Hematologic Malignancies	No drug interventions	treatment	2	completed
NCT04083170	Cord Blood Transplant With Dilanubicel for the Treatment of HIV Positive Hematologic Cancers	No drug interventions	treatment	2	terminated
NCT01273766	Deferasirox in Treating Iron Overload Caused By Blood Transfusions in Patients With Hematologic Malignancies	No drug interventions	supportive_care	2	completed
NCT00357565	Hematopoietic Stem Cell Transplantation in the Treatment of Infant Leukemia	No drug interventions	treatment	2	active_not_recruiting
NCT00012376	Chemotherapy Plus Sargramostim in Treating Patients With Refractory Myeloid Cancer	No drug interventions	treatment	1	completed
NCT01012492	Pilot of Abatacept-based Immunosuppression for Prevention of Acute GvHD During Unrelated Donor HCT	No drug interventions	treatment	2	completed
NCT02566304	Reduced Intensity Chemotherapy and Radiation Therapy Before Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies	No drug interventions	treatment	2	active_not_recruiting
NCT01789255	Vorinostat, Tacrolimus, and Methotrexate in Preventing GVHD After Stem Cell Transplant in Patients With Hematological Malignancies	No drug interventions	supportive_care	2	completed