NCT00585117
Pilot Study of (61)CuATSM-PET Imaging in Cancer Patients No drug interventions diagnostic Not Available terminated NCT04365374
Post-Surgical Stereotactic Radiotherapy (SRT) Versus GammaTile-ROADS (Radiation One and Done Study) No drug interventions treatment 3 recruiting NCT04689048
Assess Use of 18F-Fluciclovine for Patients With Large Brain Metastases Treated With Staged Stereotactic Radiosurgery prevention 1 recruiting NCT05048212
A Phase II Study of Nivolumab with Ipilimumab and Cabozantinib in Patients with Untreated Renal Cell Carcinoma Brain Metastases treatment 2 recruiting NCT05124912
REMASTer: REcurrent Brain Metastases After SRS Trial No drug interventions treatment Not Available recruiting NCT05554302
Characterization of 18F-Fluciclovine PET Amino Acid Radiotracer in Resected Brain Metastasis diagnostic 2 recruiting NCT06649058
EXCLAIM: Exploring Combined Local and Systemic Approaches In Brain Metastasis: a Multi-cohort Randomized Phase II Study Evaluating Initial Response to Systemic Therapy and Subsequent Integration of Stereotactic Radiosurgery in Patients With Low-risk Brain Metastases and Central Nervous System-active No drug interventions treatment 2 not_yet_recruiting NCT06640582
TIL Therapy Combined With Pembrolizumab for Advanced Brain Cancer Including Gliomas and Meningiomas No drug interventions treatment 1 / 2 not_yet_recruiting NCT04474925
Pre- Versus Post-operative SRS for Resectable Brain Metastases No drug interventions treatment 3 recruiting NCT05786924
A Study of BDTX-4933 in Patients With KRAS, BRAF and Select RAS/MAPK Mutation-Positive Cancers No drug interventions treatment 1 active_not_recruiting NCT06322342
Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent No drug interventions diagnostic 2 recruiting NCT06620380
Ex Vivo Drug Response Evaluation for Next Generation Care of Brain Metastases No drug interventions treatment 2 not_yet_recruiting NCT05559853
Developing a New MRI Technique to Understand Changes in Brain Tumors After Treatment No drug interventions Not Available Not Available recruiting NCT05789589
Effect of Azeliragon Combined With Stereotactic Radiation Therapy in Patients With Brain Metastases treatment 1 / 2 recruiting NCT05241873
(Concerto) Study of BLU-451 in Advanced Cancers With EGFR Exon 20 Insertion Mutations treatment 1 / 2 active_not_recruiting NCT05673928
A Phase II Study of Tucatinib and Ado-trastuzumab Emtansine (T-DM1) in Patients with HER2-positive Metastatic Solid Tumors and Metastases to Brain (TUCATEMEB) treatment 2 recruiting NCT05996432
Image-Based, In-Vivo Assessment of Tumor Hypoxia to Guide Hypoxia-Driven Adaptive Radiation Therapy No drug interventions diagnostic 0 recruiting NCT06055790
Feasibility of 18F-Fluciclovine PET/CT to Identify Brain Metastasis No drug interventions diagnostic 2 recruiting NCT06101069
Development of MRF for Characterization of Brain Tumors After Radiotherapy No drug interventions diagnostic Not Available recruiting NCT06243003
WBRT With Hippocampal-avoidance Technique Followed by SRT for Extensive-stage SCLC With Baseline Brain Metastases No drug interventions treatment 1 / 2 recruiting NCT02747303
Frameless Stereotactic Radiosurgery for Intact Brain Metastases No drug interventions treatment 2 recruiting NCT05977803
Contribution of the CEST Sequence in the Characterization of Radionecrosis of Brain Metastases of Pulmonary Origin No drug interventions diagnostic Not Available recruiting NCT02284490
High-dose Pemetrexed to Treat Lung Adenocarcinoma With Brain Metastases treatment 2 unknown_status NCT05768490
Early or Delayed Intervention of Brain Radiotherapy Combined With Almonertinib in EGFR Mutated NSCLC With Brain Metastases treatment 3 recruiting NCT03870464
LIFE - Lung Cancer, Immunotherapy, Frailty, Effect No drug interventions Not Available Not Available active_not_recruiting NCT05700721
Phase II Trial of the PARP Inhibitor Niraparib and PD-1 Inhibitor Dostarlimab in Patients With Advanced Cancers With Active Progressing Brain Metastases (STARLET) treatment 2 recruiting NCT04233021
Study of Osimertinib in Patients With a Lung Cancer With Brain or Leptomeningeal Metastases With EGFR Mutation treatment 2 active_not_recruiting NCT04047602
Radiosurgery Dose Reduction for Brain Metastases on Immunotherapy (RADREMI): A Prospective Pilot Study No drug interventions treatment Not Available completed NCT01259479
Satraplatin in Children and Young Adults With Refractory Solid Tumors Including Brain Tumors treatment 1 completed NCT02567643
Stereotactic Radiosurgery (SRS) for Multiple CNS Mets No drug interventions treatment Not Available withdrawn NCT02082587
Toronto BNB Pilot Study No drug interventions Not Available Not Available completed NCT05267587
Preop fSRS for Resectable Brain Metastases No drug interventions treatment 2 recruiting NCT04410133
Study to Establish the Diagnostic Performance of 18F Fluciclovine PET in Detecting Recurrent Brain Metastases diagnostic 3 completed NCT05378633
The CyberChallenge Trial How Much is Too Much - What is the Role of Cyberknife Radiosurgery in Patients With Multiple Brain Metastases? No drug interventions treatment 2 recruiting NCT04115254
Stereotactic Magnetic Resonance Guided Radiation Therapy No drug interventions treatment Not Available suspended NCT00522951
SH L 562BB Phase II/III Dose Justification and Gadoteridol-controlled Comparative Study diagnostic 3 completed NCT04525053
Dosimetric Validation of Scans Generated by GAN From Pre-therapeutic MRI in Stereotactic Cerebral Radiotherapy No drug interventions Not Available Not Available completed NCT04978753
the Efficacy and Safety of Anlotinib Combined With Almonertinib in the First-line Treatment of Patients With Brain Metastases From EGFR Mutation-positive Non-small Cell Lung Cancer treatment 2 unknown_status NCT04170777
Perfexion Registration Using CBCT No drug interventions Not Available Not Available completed NCT04094077
Evaluating AGuIX® Nanoparticles in Combination With Stereotactic Radiation for Brain Metastases treatment 2 terminated NCT05616377
Combination of Local Therapy and Target Therapy for Brain Metastases With EGFR Mutation No drug interventions Not Available Not Available not_yet_recruiting NCT03668847
DM-CHOC-PEN for Brain Tumors in AYA Subjects treatment 2 completed NCT04643847
A Phase II Trial of Upfront Radiotherapy Plus Almonertinib for Epidermal Growth Factor Receptor(EGFR)-Mutant Non-small-cell Lung Cancer(NSCLC) Patients With Brain Metastases treatment 2 unknown_status NCT00470847
Lapatinib in Combination With Radiation Therapy in Patients With Brain Metastases From HER2-Positive Breast Cancer treatment 1 completed NCT06132945
A Study of Cabozantinib and Nivolumab With Radiation Therapy for People With Renal Cell Carcinoma That Has Spread to the Brain treatment 1 recruiting NCT02014545
Evaluation of Lucanthone to Whole Brain Radiation Therapy in Patients With Brain Metastases From Non-Small Cell Lung Cancer treatment 2 withdrawn NCT05452005
Fluorine-18-AlphaVBeta6-Binding Peptide Positron Emission Tomography in Metastatic Non-Small Cell Lung Cancer No drug interventions diagnostic 1 recruiting NCT04857905
Dose-staged Gamma Knife Radiosurgery Versus Microsurgical Resection No drug interventions treatment Not Available recruiting NCT01516905
PET/CT Imaging of Malignant Brain Tumors With 124I-NM404 No drug interventions Not Available Not Available completed NCT01252797
Dose Escalation/De-escalation Study of Pre-operative Stereotactic Radiosurgery for Brain Metastases(RAD 1002) No drug interventions other 1 completed NCT00745797
Prophylactic Cranial Irradiation (PCI) Versus no PCI in Non Small Cell Lung Cancer After a Response to Chemotherapy No drug interventions prevention 3 terminated NCT01516983
Icotinib Combined With WBRT For NSCLC Patients With Brain Metastases and EGFR Mutation treatment 1 / 2 completed NCT00536861
Safety Study of Radiotherapy and Concurrent Erlotinib (Tarceva®) for Brain Metastases From a Non-Small Cell Lung Cancer treatment 1 completed NCT04427228
Single vs Multi-fraction SRS Patients on Immunotherapy No drug interventions treatment 2 withdrawn NCT02338011
Comparator-Controlled Study for EGFR(+) Patients With Multiple BMs From NSCLC (BROKE) (EGFR-epidermal Growth Factor Receptor;BM-brain Metastases) treatment 2 / 3 unknown_status NCT02616393
Phase 2 Study of Study of Tesevatinib in Subjects With NSCLC and Brain or Leptomeningeal Metastases treatment 2 completed NCT05807893
Study to Evaluate the Safety and Efficacy of Serplulimab Plus Bevacizumab and Chemotherapy in NSCLC Patients With Brain Metastases treatment 2 / 3 not_yet_recruiting NCT06476093
SRT Combined With Anlotinib for the Treatment of Brain Metastases From Non-small Cell Lung Cancer treatment Not Available recruiting NCT02104193
Simvastatin Effect on Radiation Therapy of Brain Metastases treatment 2 completed NCT00019578
Stereotactic Radiosurgery in Treating Patients With Brain Tumors No drug interventions treatment 1 completed NCT00614978
Lapatinib and Temozolomide for the Treatment of Progressive Brain Disease in HER-2 Positive Breast Cancer treatment 1 completed NCT05871307
Neoadjuvant vs. Intraoperative vs. Adjuvant Resection Cavity Radiotherapy of Brain Metastases No drug interventions treatment 2 recruiting NCT04193007
The Role of Brain Radiotherapy in Patients With Asymptomatic Brain Metastasis in the Era of Targeted Therapy for NSCLC No drug interventions treatment 2 unknown_status NCT01763385
Erlotinib With Concurrent Brain Radiotherapy and Secondary Brain Radiotherapy After Recurrence With Erlotinib in NSCLC Non-increased-intracranial-pressure Symptomatic Brain Metastases treatment 2 unknown_status NCT04745715
Genomic Study in Non-small Cell Lung Cancer Brain Metastasis No drug interventions Not Available Not Available completed NCT02031237
MRI Study of Changes in Blood-Brain/Tumor-Barrier Permeability in Patients With Brain Metastases During and After Radiotherapy No drug interventions Not Available Not Available completed NCT03002532
Hippocampal-sparing Whole Brain Radiotherapy for Brain Metastases From Breast Cancer No drug interventions treatment Not Available unknown_status NCT02185352
Bevacizumab, Etoposide and Cisplatin Followed by Whole Brain Radiotherapy in Breast Cancer With Brain Metastases treatment 2 unknown_status NCT04040400
Study of Intraoperative Radiotherapy for Patients With Large Brain Metastases Treated With Neurosurgical Resection No drug interventions treatment Not Available terminated NCT01736800
Phase II Trial of Chemotherapy With Temodar With Topotecan for CNS Metastasis of Solid Tumors treatment 2 withdrawn NCT01322100
Electrochemotherapy as a Palliative Treatment for Brain Metastases treatment 1 terminated NCT05054400
Study of Laser Interstitial Thermal Therapy (LITT) Treatment Response Assessment With Fluciclovine PET MR treatment 0 withdrawn NCT02328300
FLT PET/MR for Evaluation of Pseudoprogression in Patients With Brain Lesions No drug interventions Not Available Not Available withdrawn NCT04778800
A Dose Exploration Study of Almonertinib for EGFRm NSCLC Patients With Brain/Leptomeningeal Metastasis (ARTISTRY) treatment Not Available unknown_status NCT02048059
ANG1005 in Breast Cancer Patients With Recurrent Brain Metastases treatment 2 completed NCT03726359
Phase I Study of Fractionated Stereotactic Radiation Therapy No drug interventions other 1 recruiting NCT03338075
FSRT Combined With TMZ for Large BMs: a PSM Study No drug interventions Not Available Not Available completed NCT00582075
Phase II Study of Gamma Knife Radiosurgery and Temozolomide for Brain Metastases treatment 2 completed NCT03223675
Neurocognitive Impact and Dose-Effect Relationship of Hippocampal Avoidance During Whole Brain Radiotherapy Plus Simultaneous Integrated Boost - A Prospective Follow-up Study No drug interventions treatment Not Available recruiting NCT04654975
Metachronic Brain Metastases After Esophagectomy for Esophageal Cancer (METABREC) No drug interventions Not Available Not Available recruiting NCT04213170
Sintilimab Combined With Bevacizumab for Brain Metastases From Non-small Cell Lung Cancer treatment 2 unknown_status NCT02374242
Anti-PD 1 Brain Collaboration for Patients With Melanoma Brain Metastases treatment 2 active_not_recruiting NCT03951142
Imaging Perfusion Restrictions From Extracellular Solid Stress - An Open-label Losartan Study diagnostic 2 enrolling_by_invitation NCT04430842
Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QBS10072S No drug interventions treatment 1 completed NCT05588206
Dose-escalation by Hypofractionated Stereotactic Radiotherapy for Brain Metastases in Non Small Cell Lung Cancer No drug interventions treatment 1 / 2 recruiting NCT02080949
Phase I Dose Escalation in Patients With 1-3 Unresectable Brain Metastases No drug interventions treatment 1 withdrawn NCT05160818
Hypofractionated Versus Single Fraction Stereotactic Adjuvant Radiotherapy to the Resection Cavity of Brain Metastases No drug interventions treatment Not Available recruiting NCT04244019
FLT-PET / MRI Brain Mets No drug interventions Not Available Not Available recruiting NCT05146219
Study of TY-9591 in Patients With a Lung Cancer With Brain or Leptomeningeal Metastases With EGFR Mutation No drug interventions treatment 2 active_not_recruiting NCT00362817
Carboplatin and Temozolomide (Temodar) for Recurrent and Symptomatic Residual Brain Metastases treatment 1 / 2 completed NCT04507217
Tislelizumab Combined With Pemetrexed/ Carboplatin in Patients With Brain Metastases of Non-squamous NSCLC treatment 2 completed NCT02636634
Non Invasive Methods for Differential Diagnosis Radionecrosis/Recurrence After Radiosurgery of Brain Metastases No drug interventions diagnostic 3 completed NCT01281696
Bevacizumab With Etoposide and Cisplatin in Breast Cancer Patients With Brain and/or Leptomeningeal Metastasis treatment 2 completed NCT03257735
A Study of the Gene Mutation Status in Cerebrospinal Fluid, Blood and Tumor Tissue of Non-small Cell Lung Cancer Patients With Brain Metastases No drug interventions Not Available Not Available unknown_status NCT03297463
Radiation Therapy With Combination Immunotherapy for Relapsed/Refractory Metastatic Melanoma treatment 1 / 2 withdrawn NCT00791063
18F ML-10 for Early Detection of Response of Brain Metastases to WBRT No drug interventions diagnostic 2 completed NCT04395339
GM1 Prophylaxis for WBRT Related Cognitive Dysfunction treatment 3 terminated NCT02576522
Tumor Bed Hypofractionated IMRT After Surgery for Patients With Single,Large Brain Metastases From Solid Tumor No drug interventions treatment Not Available completed NCT05638425
Radiotherapy Combined With PD-1 Inhibitors and Chemotherapy in the Treatment of NSCLC Patients With Symptomatic Brain Metastases No drug interventions Not Available Not Available recruiting NCT03368625
A Study of Neoadjuvant Stereotactic Radiosurgery for Large Brain Metastases No drug interventions treatment Not Available recruiting NCT03593330
Neurosurgical Transitional Care Programme No drug interventions health_services_research Not Available unknown_status NCT04334330
Palbociclib, Trastuzumab,Pyrotinib and Fulvestrant Treatment in Patients With Brain Metastasis From ER/PR Positive, HER-2 Positive Breast Cancer: A Multi-center, Prospective Study in China treatment 2 recruiting NCT03775330
Radiosurgery With or Without Whole Brain Radiation for Multiple Metastases No drug interventions Not Available Not Available recruiting NCT05255666
Combination Liposomal Irinotecan and Pembrolizumab For Triple-Negative Breast Cancer (TNBC) With Brain Metastases (BM) treatment 2 withdrawn NCT03303365
Cyberknife Radiosurgery for Patients With Brain Metastases Diagnosed With Either SPACE or MPRAGE Sequence No drug interventions treatment Not Available completed NCT03638765
Dendritic Cell Therapy for Brain Metastases From Breast- or Lung Cancer No drug interventions treatment 1 unknown_status NCT06318065
Surgical Resection Outcomes in Patients With Brain Metastasis No drug interventions Not Available Not Available recruiting NCT05305365
Study Assessing QBS72S For Treating Brain Metastases No drug interventions treatment 2 recruiting NCT03728465
Evaluation of Safety and Efficacy of Patients With Four and More Symptomatic Brain Metastases of Melanoma treatment 2 terminated NCT06471465
Corticodependent or Corticoresistant Brain Radionecrosis After Radiotherapy for Brain Metastases treatment 3 not_yet_recruiting NCT03807765
Stereotactic Radiation and Nivolumab in the Management of Metastatic Breast Cancer Brain Metastases treatment 1 active_not_recruiting NCT02460874
Glyburide vs Placebo as Prophylaxis Against Cerebral Edema in Patients Receiving Radiosurgery for Brain Metastases (RAD 1502/UAB 1593) treatment 1 / 2 terminated NCT04415320
X-396 (Ensartinib) Capsules in ALK-Positive NSCLC Patients With Brain Metastases treatment 2 unknown_status NCT04042220
Glucocorticoids, Immunotherapy and Radiosurgery for Brain Metastases No drug interventions Not Available Not Available completed NCT02308020
A Study of Abemaciclib (LY2835219) in Participants With Breast Cancer, Non-small Cell Lung Cancer, or Melanoma That Has Spread to the Brain treatment 2 completed NCT02000882
STAR Cape+BKM120 MBC With Brain Met treatment 2 completed NCT01951482
Pemetrexed/Cisplatin With or Without Bevacizumab in Brain Metastases From Non Squamous Non-small Cell Lung Cancer treatment 2 unknown_status NCT02879682
nTMS for Motor Mapping of Rolandic Lesions No drug interventions diagnostic 2 / 3 completed NCT03247127
Memory Preservation of Hippocampal Avoidance Whole Brain Radiotherapy No drug interventions supportive_care Not Available unknown_status NCT05419076
A Study of Stereotactic Radiosurgery (SRS) for People With Lung Cancer That Has Spread to the Brain No drug interventions treatment 2 recruiting NCT03366376
Hippocampus-sparing WBRT and Simultaneous Integrated Boost for Multiple Brain Metastases From NSCLC No drug interventions treatment 2 unknown_status NCT06180460
CALM: Managing Distress in Malignant Brain Cancer No drug interventions supportive_care Not Available recruiting NCT06048094
18F-Fluciclovine PET Amino Acid Evaluation of Brain Metastasis Treated With Stereotactic Radiosurgery diagnostic 1 recruiting NCT03398694
Pre-operative Stereotactic Radiosurgery Followed by Resection for Patients With Brain Metastases No drug interventions treatment Not Available completed NCT03550391
Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases treatment 3 recruiting NCT06501391
Cranial Radiotherapy Plus Chemoimmunotherapy in Untreated Driver-mutation Negative NSCLC With Stable Brain Metastasis No drug interventions treatment 2 recruiting NCT01386580
An Open-label, Phase I/IIa, Dose Escalating Study of 2B3-101 in Patients With Solid Tumors and Brain Metastases or Recurrent Malignant Glioma. treatment 1 / 2 completed NCT03520829
Protocol for Evaluating a Planning Algorithm for Gamma Knife Radiosurgery No drug interventions Not Available Not Available unknown_status NCT05737589
Circulating Tumor DNA and T Cell Repertoire Predict Radiotherapeutic Outcomes in NSCLC Patients With Brain Metastasis No drug interventions Not Available Not Available not_yet_recruiting NCT04291092
Camrelizumab Combined With Local Treatment in NSCLC Patients With BM treatment 2 unknown_status NCT05013892
NTS-WBRT in Brain Metastases treatment 2 recruiting NCT03027544
Tomotherapy for Refractory Brain Metastases No drug interventions treatment Not Available unknown_status NCT06209567
A Study of 68Ga-PSMA-11 PET Scans in People With Brain Tumors No drug interventions diagnostic 0 recruiting NCT00854867
Study to Demonstrate the Safety of WBR Administered at the Same Time as Intrathecal Liposomal Cytarabine (DepoCyte®) Versus Intrathecal Liposomal Cytarabine (DepoCyte®) Administered After WBR for the Treatment of Solid Tumour Neoplastic Meningitis in Patients With or Without Brain Metastasis. treatment 1 completed NCT04410367
Study to Establish Image Interpretation Criteria for 18F Fluciclovine PET in Detecting Recurrent Brain Metastases (PURSUE) diagnostic 2 completed NCT05346367
Improving Therapeutic Ratio With Hypo Fractionated Stereotactic Radiotherapy for Brain Metastases No drug interventions treatment Not Available recruiting NCT01731704
Neurocognitive Outcomes In Patients Treated With Radiotherapy For Five Or More Brain Metastases No drug interventions treatment Not Available withdrawn NCT04503772
Preoperative Stereotactic Radiosurgery for Brain Metastases No drug interventions treatment 2 recruiting NCT05762172
Dynamic F-DOPA PET for Differential Diagnosis Between Recurrence and Radionecrosis of Brain Metastasis No drug interventions diagnostic Not Available recruiting NCT01951469
Gefitinib With or Without Chemotherapy in Brain Metastases From Non-small Cell Lung Cancer treatment 3 unknown_status NCT02605746
Preoperative Ceritinib (LDK378) in Glioblastoma Multiforme and CNS Metastasis other 0 completed NCT02215512
Dose-Escalation Study of RRx-001 in Combination With Whole Brain Radiation in Subjects With Brain Metastases treatment 1 completed NCT03412812
A Dose Escalation Trial of Five Fraction Stereotactic Radiation Therapy for Brain Metastases No drug interventions treatment Not Available active_not_recruiting NCT06315010
REPotrectinib in ROS1-positive Non-small Cell Lung Cancer Patients With Active Brain mEtastasis treatment 2 not_yet_recruiting NCT04634110
Brigatinib Before Brain Irradiation Trial (B3i Trial) treatment 2 terminated NCT04079595
Closed vs. Open Face Masks for Cranial Radiotherapy No drug interventions other Not Available completed NCT02005614
A Pilot/Phase II Study of Gamma Knife Radiosurgery for Brain Metastases Using 3Tesla MRI and Rational Dose Selection No drug interventions treatment Not Available terminated NCT04712214
Use of Non-invasive Optical Analysis in Neurosurgery No drug interventions other Not Available recruiting NCT04545814
Analyzing Preoperative Stereotactic Radiosurgery With Gamma Knife Icon for Brain Metastases No drug interventions treatment Not Available completed NCT03346655
Brain Metastases in Norway - A Prospective Cohort Study No drug interventions Not Available Not Available active_not_recruiting NCT05045950
Optimizing Neurocognition With Whole Brain Radiation Therapy (WBRT) Using Upfront Pulsed Reduced Dose-Rate (PRDR) Technique treatment 2 recruiting NCT01046123
Volumetric Modulated Arc Therapy (VMAT) for Brain Metastases No drug interventions treatment Not Available active_not_recruiting NCT03898908
Encorafenib and Binimetinib Before Local Treatment in Patients With BRAF Mutant Melanoma Metastatic to the Brain treatment 2 active_not_recruiting NCT04675008
Central Nervous System(CNS) Efficacy of Dacomitinib treatment 2 unknown_status NCT04955743
Pembrolizumab and Lenvatinib in Patients With Brain Metastases From Melanoma or Renal Cell Carcinoma treatment 2 recruiting NCT00538343
RTA 744 in Breast Cancer Patients With Progression of Previously Irradiated Brain Metastases treatment 2 terminated NCT02974803
Concurrent Dabrafenib + Trametinib With Sterotactic Radiation in BRAF Mutation-Positive Malignant Melanoma and Brain Metastases treatment 2 terminated NCT03769103
Study of Osimertinib + SRS vs Osimertinib Alone for Brain Metastases in EGFR Positive Patients With NSCLC treatment 2 recruiting NCT00805103
Perfexion Brain Metastasis No drug interventions treatment 1 terminated NCT04277403
HA-WBRT vs SRS in Patients With Multiple Brain Metastases No drug interventions treatment 3 unknown_status NCT04211090
Camrelizumab With AC in Patients With Brain Metastases of Driven Gene-negative,NSCLC treatment 2 active_not_recruiting NCT04650490
SRS Timing With Immune Checkpoint Inhibition in Patients With Untreated Brain Metastases From Non-small Cell Lung Cancer No drug interventions treatment 2 withdrawn NCT00981890
Stereotactic Radiosurgery With Sunitinib for Brain Metastases treatment 1 completed NCT03606421
CBF and NCF Changes With Brain Radiation No drug interventions Not Available Not Available recruiting NCT04452084
Phase 2 Trial in Multiple Brain Metastases Outcomes With HA-SIB-WBRT No drug interventions treatment 2 active_not_recruiting NCT04610684
Chemotherapy and Atezolizumab for Patients With Extensive Stage Small Cell Lung Cancer (SCLC) With Untreated, Asymptomatic Brain Metastases treatment 2 terminated NCT04847284
Intraoperative Radiotherapy in Patients With Brain Metastases No drug interventions treatment Not Available recruiting NCT04824079
Keynatinib in Treated Patients With NSCLC and Brain Metastases No drug interventions treatment 2 recruiting NCT04246879
MRI Following Stereotactic Radiosurgery (SRS) for Brain Metastases No drug interventions other Not Available recruiting NCT06557187
Hippocampus-Avoidance Whole-Brain Radiation Therapy With Simultaneous Integrated Boost for BMs of NSCLC No drug interventions treatment Not Available completed NCT02972333
Open Label, Prospective Study to Investigate Efficacy and Safety of AZD9291 in BM From NSCLC Patients With EGFR T790M treatment 3 unknown_status NCT02820454
Radiosensitization of Multiple Brain Metastases Using AGuIX Gadolinium Based Nanoparticles treatment 1 completed NCT02058953
CNS and Extracranial Tumor Tissues, CSF, and Blood From Patients With Melanoma Brain Metastases No drug interventions Not Available Not Available completed NCT05139277
Evaluation of the CONVIVO System No drug interventions diagnostic Not Available recruiting NCT03430947
Vemurafenib Plus Cobimetinib After Radiosurgery in Patients With BRAF-mutant Melanoma Brain Metastases treatment 2 terminated NCT04158947
A Study of HER2+ Breast Cancer Patients With Active Brain Metastases Treated With Afatinib & T-DM1 vs. T-DM1 Alone treatment 2 unknown_status NCT02037945
18F-Fluorocholine (18F-FCho) to Distinguish Necrosis From Recurrence in Brain Metastases No drug interventions diagnostic Not Available completed NCT04420598
DS-8201a for trEatment of aBc, BRain Mets, And Her2[+] Disease treatment 2 completed NCT02735798
64-Cu Labeled Brain PET/MRI for MM-302 in Advanced HER2+ Cancers With Brain Mets treatment 0 withdrawn NCT03881605
MRI Screening Versus SYMptom-directed Surveillance for Brain Metastases Among Patients With Triple Negative or HER2+ MBC No drug interventions screening Not Available unknown_status NCT01173497
A Study Evaluating INIPARIB in Combination With Chemotherapy to Treat Triple Negative Breast Cancer Brain Metastasis treatment 2 completed NCT03226483
Intraoperative Radiotherapy After the Resection of Brain Metastases No drug interventions treatment Not Available unknown_status NCT01480583
GRN1005 Alone or in Combination With Trastuzumab in Breast Cancer Patients With Brain Metastases treatment 2 completed NCT04512261
TOPAZ: Tucatinib in COmbination With Pembrolizumab And TrastuZumab in Patients With HER2-Positive Breast Cancer Brain Metastases treatment 1 / 2 withdrawn NCT05868928
Imaging Features for the Risks for Recurrence After Stereotactic Radiosurgery in Brain Metastasis No drug interventions Not Available Not Available recruiting NCT04890028
Detection and Metabolic Characterization in DOPA PET/CT of Brain Metastases No drug interventions diagnostic Not Available recruiting NCT02147028
Hippocampal Sparing Whole Brain Radiotherapy vs Conventional Whole Brain Radiotherapy in Patients With Brain Metastases No drug interventions treatment 2 completed NCT01476878
Frameless Stereotactic Radiosurgery for Brain Metastases No drug interventions treatment 1 / 2 unknown_status NCT02490878
Corticosteroids + Bevacizumab vs. Corticosteroids + Placebo (BEST) for Radionecrosis After Radiosurgery for Brain Metastases supportive_care 2 terminated NCT03297788
Whole Brain Radiation Therapy Alone vs. Radiosurgery for SCLC Patients With 1-10 Brain Metastases No drug interventions treatment Not Available completed NCT02504788
A Prospective Study of the Impact of Hippocampal Avoidance During Whole Brain Radiotherapy on Neurocognitive Function Decline No drug interventions treatment Not Available recruiting NCT06072807
Brain [18F]-FES PET/CT in Patients With Estrogen-Receptor Positive Breast Cancer No drug interventions treatment 4 recruiting NCT05270707
HyperArc Registry Study No drug interventions Not Available Not Available recruiting NCT01535209
Stereotactic Radiotherapy of Resection Cavity For Single Brain Metastasis Versus Whole-Brain Radiotherapy After Resection No drug interventions treatment 3 unknown_status NCT03910556
Re-craniotomy and Complications After Elective Neurosurgery Not Available Not Available completed NCT06088056
A Phase II Study of T-DXd Plus SRT in HER2-positive Breast Cancer Brain Metastases No drug interventions treatment 2 not_yet_recruiting NCT06405256
Magnetic Resonance Imaging-guided Adaptive Radiotherapy for Large Brain Metastases No drug interventions Not Available Not Available recruiting NCT02311556
Response of Brain Metastases After Gamma-Knife Radiosurgery Using Dynamic Susceptibility-weighted Contrast-enhanced Perfusion Magnetic Resonance Imaging No drug interventions diagnostic 1 completed NCT02886585
Pembrolizumab In Central Nervous System Metastases treatment 2 active_not_recruiting NCT03753685
X-396(Ensartinib) Capsules in ALK-Positive NSCLC Patients With Brain Metastases treatment 2 unknown_status NCT05177185
Hippocampal-Sparing Stereotactic Radiosurgery Treatment of Brain Metastases Using CyberKnife No drug interventions treatment 2 not_yet_recruiting NCT05573815
Evaluation of Clinical Decision Support System for Brain Metastasis Using Brain MR Images No drug interventions diagnostic Not Available recruiting NCT02097732
Ipilimumab Induction in Patients With Melanoma Brain Metastases Receiving Stereotactic Radiosurgery treatment 2 terminated NCT03508752
Neurocognitive Decline in Patients With Brain Metastases No drug interventions treatment 1 / 2 recruiting NCT03356600
Apatinib Plus Radiotherapy for Patients With Brain Metastases From Non-small-cell Lung Cancer treatment 2 unknown_status NCT00876759
Whole-Brain Radiotherapy (WBRT) Versus WBRT and Integrated Boost Using Helical Tomotherapy for Multiple Brain Metastases No drug interventions treatment 2 unknown_status NCT00717275
Study of Temozolomide to Treat Newly Diagnosed Brain Metastases treatment 2 terminated NCT04856475
Evaluation of Neratinib for Treatment and Prevention of Subsequent CNS Event(s) in Patients With Brain Metastasis of Advanced HER2 Positive Breast Cancer treatment 2 withdrawn NCT02085070
MK-3475 in Melanoma and NSCLC Patients With Brain Metastases treatment 2 completed NCT01410370
Continuous Endostar Infusion Combined With Radiotherapy in Patients With Brain Metastases treatment 2 unknown_status NCT04923542
Stereotactic Radiation & Abemaciclib in the Management of HR+/HER2- Breast Cancer Brain Metastases treatment 1 / 2 recruiting NCT02599142
Comparing Immobilisation Shells in Cranial Radiotherapy No drug interventions treatment Not Available completed NCT01724606
Whole Brain Radiotherapy (WBRT) With Sorafenib for Breast Cancer Brain Metastases (BCBM) treatment 1 completed NCT06457906
SRS/SRT/Hypo-RT Versus HA-WBRT for No More Than 10 Brain Metastases in SCLC No drug interventions treatment 3 recruiting NCT02654106
Stereotactic Radiotherapy Plus Temozolomide for Refractory Brain Metastases treatment 2 completed NCT00805636
Evaluation of the Efficacy and Safety of [18F]-ML-10, as a PET Imaging Radiotracer, in Early Detection of Response of Brain Metastases of Solid Tumors to Radiation Therapy. diagnostic 2 unknown_status NCT05948813
TY-9591 in the Patients With EGFR Mutations in Advanced NSCLC With Brain Metastases treatment 2 recruiting NCT01688713
Phase II Trial of Double Dose of Icotinib in Treating Brain Metastases From Non-small Cell Lung Cancer treatment 2 unknown_status NCT01540513
PET/CT Evaluation of Primary and Metastatic Brain Tumors With a Novel Radioiodinated Phospholipid Ether Analogue I-NM404 No drug interventions diagnostic Not Available completed NCT05535413
UTD1 Combined With Capecitabine in Metastatic HER2-negative Breast Cancer Patients With Brain Metastases treatment 1 / 2 recruiting NCT03626818
The Impact of Neurocognitive Function in Patients With Multiple Brain Metastases Receiving Whole Brain Radiation Therapy No drug interventions Not Available Not Available unknown_status NCT02390518
Stereotactic Radiosurgery Dose Escalation for Brain Metastases No drug interventions treatment 1 recruiting NCT03778541
HFSRT With Concurrent TMZ for Large BMs treatment 3 unknown_status NCT05459441
Efficacy and Safety Evaluation of Percutaneous Ommaya Capsule Injection of Autologous Bi-dimensional Specific T Cells in the Treatment of Glioma and in Combination With Pemetrexed in the Treatment of Brain/Meningeal Metastases treatment 0 unknown_status NCT05812534
Study of Cadonilimab Combined With Bevacizumab and Chemotherapy for Advanced Nonsquamous Non-small Cell Lung Cancer Patients With Untreated Brain Metastases treatment 2 not_yet_recruiting NCT05477316
A Study to Assess the Efficacy of Cerebellar IMRT Combined With Cerebral SRS in Patients With Brain Metastases No drug interventions treatment Not Available recruiting NCT01421316
Hair-sparing Whole Brain Radiotherapy No drug interventions treatment 2 terminated NCT04074096
Binimetinib Encorafenib Pembrolizumab +/- Stereotactic Radiosurgery in BRAFV600 Melanoma With Brain Metastasis treatment 2 active_not_recruiting NCT05692635
Reducing the Incidence of Symptomatic Brain Metastases With MRI Surveillance diagnostic 2 recruiting NCT04833335
ASL in Brain Metastasis MRI Following Gamma Knife Treatment No drug interventions diagnostic Not Available recruiting NCT04334863
WP1066 in Children With Refractory and Progressive or Recurrent Malignant Brain Tumors treatment 1 completed NCT01850563
A Proof-of-principle Study of HBO-SRS for Brain Metastases No drug interventions treatment Not Available completed NCT02115139
GEM STUDY: Radiation And Yervoy in Patients With Melanoma and Brain Metastases treatment 2 completed NCT04422639
Preoperative SRS/SRT vs Postoperative SRS/SRT for Brain Metastases No drug interventions treatment Not Available terminated NCT02581839
Treatment of Brain Metastases From Breast Cancer With Eribulin Mesylate treatment 2 completed NCT05553522
Tucatinib, Trastuzumab, and Capecitabine With SRS for Brain Metastases From HER-2 Positive Breast Cancer treatment 1 recruiting NCT03223922
Neurocognitive Functioning With Genu-Sparing Whole Brain Radiation Therapy for Brain Metastases No drug interventions treatment Not Available recruiting NCT02187822
Fractionated Stereotactic Radiotherapy (FSRT) in Treatment of Brain Metastases treatment 1 terminated NCT00820222
Lapatinib Plus Capecitabine Versus Trastuzumab Plus Capecitabine in ErbB2 (HER2) Positive Metastatic Breast Cancer treatment 3 completed NCT04001725
Efficacy of metfOrmin in PrevenTIng Glucocorticoid-induced Diabetes in Patients With Brain Metastases prevention 2 unknown_status NCT04178330
Tomotherapy as Primary Radiotherapy for Multipule Brain Metastases No drug interventions treatment Not Available completed NCT03754530
Icotinib Combined With Radiation Therapy For NSCLC Patients With Brain Metastases and EGFR Mutation treatment 2 unknown_status NCT04700748
Diffusion-weighted MRI to Predict Treatment Response in Stereotactic Radiotherapy of Central Nervous System (CNS) Metastases No drug interventions diagnostic Not Available unknown_status NCT00437957
Phase I Study of Temozolomide, Valproic Acid and Radiation Therapy in Patients With Brain Metastases treatment 1 terminated NCT05185557
BRIANSTORM - Early Identification of Patients With Brain Metastases No drug interventions Not Available Not Available active_not_recruiting NCT04073966
MRI Biomarkers for Radiation-Induced Neurocognitive Decline Following SRS of Newly Diagnosed Brain Mets No drug interventions Not Available Not Available recruiting NCT02065466
Combo of Abraxane, TMZ, Bevacizumab in Metastatic Melanoma With Brain Metastases treatment 1 / 2 withdrawn NCT06020066
SRS for NSCLC With Oligo-residual Intracranial Disease After First-line 3rd Generation EGFR-TKI No drug interventions treatment 2 recruiting NCT04358666
Evaluation of the Best Treatment in Terms of Quality of Life for Patients Having a Brain Metastasis No drug interventions other Not Available unknown_status NCT06045065
Preclinical Brain Tumor Models No drug interventions Not Available Not Available recruiting NCT06282874
Lorlatinib in Patients With ALK-Positive NSCLC With Brain or Leptomeningeal Metastases treatment 4 not_yet_recruiting NCT06466720
Measuring and Mapping Cognitive Decline After Brain Radiosurgery No drug interventions Not Available Not Available not_yet_recruiting NCT04755920
SGM-101 in Colorectal Brain Metastases. No drug interventions treatment 2 recruiting NCT03933982
A Study of Pyrotinib Plus Vinorelbine in Patients With Brain Metastases From HER2-positive Metastatic Breast Cancer treatment 2 unknown_status NCT06238882
Nitroglycerin Plus Radiotherapy Versus Conventional Radiotherapy in Patients With Lung Cancer. treatment Not Available recruiting NCT04760431
TKIs vs. Pertuzumab in HER2+ Breast Cancer Patients With Active Brain Metastases (HER2BRAIN) treatment 2 not_yet_recruiting NCT04084431
Supportive Care With or Without Repeated Whole Brain Radiotherapy in Patients With Recurrent Brain Metastases No drug interventions treatment Not Available suspended NCT00879073
Study Bendamustine Concurrent Whole Brain Radiation Brain Metastases From Solid Tumors treatment 1 terminated NCT04967027
Phase 1 Trial for Tumor Treating Field for Drug/Radiation Resistant Brain Metastases No drug interventions device_feasibility 0 unknown_status NCT03324360
Role of Hyperpolarized 13C-Pyruvate MR Spectroscopy in Patients With Intracranial Metastasis Treated With (SRS) No drug interventions other 1 recruiting NCT05033691
A Study to Evaluate the Efficacy of Osimertinib With Early Intervention SRS Treatment Compared to the Continuation of Osimertinib Alone, in Patients With EGFR Mutated NSCLC and Asymptomatic Brain Metastases No drug interventions treatment Not Available recruiting NCT02220491
Whole Brain Radiotherapy Versus Volumetric Modulated Arc Therapy for Brain Metastases No drug interventions treatment Not Available completed NCT03391362
Stereotactic Radiation in Patients With Small Cell Lung Cancer and 1-10 Brain Metastases No drug interventions treatment Not Available active_not_recruiting NCT00639262
Combination of Sorafenib and Radiation for Brain Metastases and Primary Brain Tumors treatment 1 completed NCT03698162
Precise DCE-MRI in Diagnosing Participants With Recurrent High Grade Glioma or Melanoma Brain Metastases diagnostic Not Available terminated NCT00513162
Valproate and Etoposide for Patients With Neuronal Tumors and Brain Metastases treatment 1 completed NCT05609162
Treatments for Brain Metastases With Poor Prognostic Factors No drug interventions Not Available Not Available enrolling_by_invitation NCT05064280
Phase II Study of Pembrolizumab in Combination With Lenvatinib in Patients With TNBC, NSCLC, and Other Tumor Types and Brain Metastases treatment 2 recruiting NCT01551680
A Trial Evaluating Concurrent Whole Brain Radiotherapy and Iniparib in Multiple Non Operable Brain Metastases No drug interventions treatment 1 terminated NCT00838929
Study of the Combination of Vorinostat and Radiation Therapy for the Treatment of Patients With Brain Metastases treatment 1 completed NCT01218529
Lapatinib and WBRT for Patients With Brain Metastases From Lung or Breast Tumors treatment 2 completed NCT03332589
E6201 Plus Dabrafenib for the Treatment of Metastatic Melanoma Central Nervous System Metastases (CNS) treatment 1 terminated NCT00663689
Efficacy of Erlotinib for Brain Metastasis of Non-Small Cell Lung Cancer treatment 2 unknown_status NCT05464992
Use of CEST (Chemical Exchange Saturation Transfer) Imaging in PET/MRI No drug interventions other Not Available recruiting NCT00602992
Exploring the Role of 3T MRI in Gamma Knife Radiosurgery No drug interventions Not Available Not Available completed NCT05987644
Delayed or Upfront Brain RAdiotherapy in Treatment naïve Lung Cancer Patients With Asymptomatic or Minimally Symptomatic Brain Metastases and ALK rEarrangements treatment 1 / 2 recruiting NCT03414944
Elective Simultaneous Modulated Accelerated Brain Radiation Therapy for NSCLCs With Limited Brain Metastases No drug interventions treatment Not Available unknown_status NCT05358340
Dual Perfusion Imaging for Characterizing Vascular Architecture of Brain Lesions No drug interventions diagnostic Not Available recruiting NCT06410040
A Retrospective Study of the Efficacy and Safety of Lolatinib in ALK+ NSCLC Patients With Brain or Meningeal Metastasis Not Available Not Available active_not_recruiting NCT03525301
Short Course Radiation Therapy in Palliative Treatment of Brain Metastases No drug interventions treatment Not Available unknown_status NCT04180501
SRS Sequential Sindilimab in Brain Metastasis of NSLSC treatment 2 unknown_status NCT05207904
Tislelizumab Plus Chemotherapy as First-Line Treatment for Advanced Squamous NSCLC With Brain Metastases treatment 2 unknown_status NCT04058704
A Study to Determine the Efficiency For Brain Metastasis NSCLC Patients Treated With Icotinib Alone or Combined With Radiation Therapy treatment 3 unknown_status NCT03075072
Hippocampal Sparing Whole Brain Radiation Versus Stereotactic Radiation in Patients With 5-20 Brain Metastases: A Phase III, Randomized Trial No drug interventions treatment Not Available recruiting NCT03488472
Radiosurgery Plus NovoTTF-200A for Metastatic Small Cell Lung Cancer to the Brain No drug interventions treatment Not Available terminated NCT04582968
Pyrotinib Combined With Brain Radiotherapy in Breast Cancer Patients With Brain Metastases No drug interventions treatment 1 / 2 active_not_recruiting NCT02460068
A Study of Fotemustine(FTM) Vs FTM and Ipilimumab (IPI) or IPI and Nivolumab in Melanoma Brain Metastasis treatment 3 unknown_status NCT03163368
Dose Escalation Trial of Neoadjuvant Radiosurgery for the Treatment of Metastatic Brain Tumors No drug interventions treatment 0 active_not_recruiting NCT02726568
High Dose Icotinib With Sequential SRS For NSCLC Patients Harboring EGFR Mutation With Brain Metastases treatment 2 unknown_status NCT01578668
Erlotinib Plus Pemetrexed to Treat Lung Adenocarcinoma With Brain Metastases treatment 2 completed NCT02732769
Clinical Evaluation of the Treatment of Intellectual Metastases by Radiosurgery Gamma Knife by Means of a Support System by Mask. No drug interventions basic_science Not Available completed NCT03911869
An Open-Label, Randomized, Multicenter Trial of Encorafenib + Binimetinib Evaluating a Standard-dose and a High-dose Regimen in Patients With BRAFV600-mutant Melanoma Brain Metastasis treatment 2 terminated NCT03653546
First Line Treatment in EGFR Mutation Positive Advanced NSCLC Patients With Central Nervous System (CNS) Metastases treatment 2 / 3 completed NCT00589212
GliaSite 1-3 Mets Study No drug interventions treatment 2 completed NCT03189381
Pilot Phase 2 Study Whole Brain Radiation Therapy With Simultaneous Integrated Boost for Patients With Brain Metastases No drug interventions treatment Not Available terminated NCT03613181
ANG1005 in Leptomeningeal Disease From Breast Cancer treatment 3 not_yet_recruiting NCT01258881
Retrospective Study of Ovarian Cancer Patients With Brain Metastasis No drug interventions Not Available Not Available unknown_status NCT04192981
GDC-0084 With Radiation Therapy for People With PIK3CA-Mutated Solid Tumor Brain Metastases or Leptomeningeal Metastases treatment 1 active_not_recruiting NCT06015295
A Pilot Study to Assess the Clinical Utility of 18F-Fluciclovine (Axumin) PET-CT for Detecting True-versus Pseudo-Progression of Brain Metastases on Immunotherapy No drug interventions diagnostic Not Available not_yet_recruiting NCT03458455
Improved Therapy Response Assessment in Metastatic Brain Tumors Not Available Not Available active_not_recruiting NCT05323955
Secondary BRain Metastases Prevention After Isolated Intracranial Progression on Trastuzumab/Pertuzumab or T-DM1 in Patients With aDvanced Human Epidermal Growth Factor Receptor 2+ brEast Cancer With the Addition of Tucatinib treatment 2 recruiting NCT05848050
Evaluation of the Humoral and Tumoral Molecular Alteration Profile of Brain Metastases No drug interventions prevention Not Available recruiting NCT06289023
HA-WBRT-SIB for Brain Metastasis of Lung Cancer No drug interventions treatment 2 completed NCT06511323
Evaluation of Brain Metastases Treated With Stereotactic Radiotherapy Using Dynamic [18F]FDG PET No drug interventions diagnostic Not Available not_yet_recruiting NCT04899908
Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases treatment 2 recruiting NCT04061408
FSRT in Breast Cancer Patients With Brain Metastases No drug interventions treatment 2 unknown_status NCT03449238
Pembrolizumab And Stereotactic Radiosurgery (Srs) Of Selected Brain Metastases In Breast Cancer Patients treatment 1 / 2 recruiting NCT01821443
A Single Arm Study of Neurocognitive Outcomes in Patients With Brain Metastases Managed With Stereotactic Radiosurgery (SRS) No drug interventions treatment Not Available terminated NCT05465343
Efficacy and Safety of Furmonertinib in Patients With EGFR Mutations in Advanced NSCLC With Brain Metastases: A Single-center, Open-label, Phase II Trial（iFORCE） No drug interventions treatment 2 unknown_status NCT03714243
Blood Brain Barrier Disruption (BBBD) Using MRgFUS in the Treatment of Her2-positive Breast Cancer Brain Metastases No drug interventions device_feasibility Not Available unknown_status NCT05704933
Pilot Study of Nivolumab w/Ipilimumab or Relatlimab in Surgically Resectable Melanoma Brain Metastases treatment 0 active_not_recruiting NCT03717142
Feasibility of the LUM Imaging System for Detection of Cancer to the Brain No drug interventions other Not Available suspended NCT00585741
Pilot Study of 18F-FLT PET No drug interventions treatment Not Available terminated NCT00587964
Phase II Trial of Stereotactic Radiosurgery Boost Following Surgical Resection for Brain Metastases No drug interventions treatment 2 completed NCT01894633
Study of Whole-brain Irradiation With Chloroquine for Brain Metastases treatment 2 terminated NCT02580045
Pharmacokinetics of Systemic Anti-Cancer Therapies in the Cerebrospinal Fluid (CSF) of Patients With Advanced Cancer No drug interventions Not Available Not Available terminated NCT02433171
Methionine and PBR28-PET (Peripheral Benzodiazepine Receptors) in Brain Metastases Following Radiosurgery No drug interventions Not Available Not Available terminated NCT01395407
Phase I Trial of Stereotactic Radiosurgery Following Surgical Resection of Brain Metastases No drug interventions treatment 1 completed NCT00614809
Efficacy of Gefitinib for Brain Metastasis of Non-Small Cell Lung Cancer treatment 2 unknown_status NCT01600742
Vorinostat and Concurrent Whole Brain Radiotherapy for Brain Metastasis treatment 2 terminated NCT02681549
Pembrolizumab Plus Bevacizumab for Treatment of Brain Metastases in Metastatic Melanoma or Non-small Cell Lung Cancer treatment 2 active_not_recruiting NCT02913534
Hypofractionated Stereotactic Radiation Therapy of Brain Metastases: Evaluation of Whole-brain Radiotherapy No drug interventions Not Available Not Available completed NCT02832635
A Clinical Trial on Whole-brain Radiotherapy With Temozolomide Concurrent Chemotherapy or Avoidance of Hippocampus for Patients of Brain Metastases treatment 2 unknown_status NCT02662725
Ipilimumab Combined With a Stereotactic Radiosurgery in Melanoma Patients With Brain Metastases treatment 2 completed NCT01363557
Assess the Efficacy of Whole Brain Radiation Therapy in Lung Cancer Patients With Brain Metastasis treatment Not Available terminated NCT02448992
Hippocampal-Sparing Prophylactic Cranial Irradiation in Pathologically Nodal Positive Non-Small-Cell Lung Cancer No drug interventions treatment 2 / 3 recruiting NCT02279992
Pilot Study of Vardenafil and Carboplatin in Patients With Gliomas and Brain Metastases treatment 0 terminated NCT06582940
Elimination of PTV Margins Based on MRI-guided Adaptive Stereotactic Radiotherapy for Non-small Cell Lung Cancer With Brain Metastasis No drug interventions treatment 2 recruiting NCT03190967
T-DM1 Alone Versus T-DM1 and Metronomic Temozolomide in Secondary Prevention of HER2-Positive Breast Cancer Brain Metastases Following Stereotactic Radiosurgery treatment 1 / 2 terminated NCT01913067
Evaluation of Cabazitaxel in Patients With Brain Metastasis Secondary to Breast Cancer and NSCLC treatment 2 withdrawn NCT02425072
NovoTTF-100A Therapy for Refractory CNS Involved Small Cell Lung Cancer No drug interventions treatment 2 withdrawn NCT01891708
VEGFRs Predict Bevacizumab Benefit in Advanced Non Small Cell Lung Cancer No drug interventions Not Available Not Available unknown_status NCT01508221
Evaluation of the Use of Trental and Vitamin E For Prophylaxis of Radiation Necrosis prevention 2 completed NCT06462079
Sacituzumab Govitecan Combined With Head Radiotherapy for Her2-negative Breast Cancer Brain Metastases treatment 2 not_yet_recruiting NCT05102747
Stereotactic Radiotherapy in Oligometastatic Brain Disease: a Randomised Phase III Study Comparing Hypofractionated Stereotactic Radiation Therapy (3*10 Gy) to the Historical Single-dose Radiosurgery (1*20 to 25 Gy) With Medico-economic Evaluation. No drug interventions treatment Not Available active_not_recruiting NCT02013297
Study of SBRT Efficacy on Intra and Extra -Cranial Tumors or Metastasis in Pediatrics Population (SBRT Pediatrics) No drug interventions treatment Not Available completed NCT00219297
Study of Patupilone in Patients With Brain Metastasis From Non-small Cell Lung Cancer treatment 2 completed NCT01445483
Neuropsychological Changes in Patients Receiving Radiation Therapy for Brain Metastases No drug interventions Not Available Not Available completed NCT02621515
Nivo/Ipi Combination Therapy in Symptomatic Brain Metastases diagnostic 2 terminated NCT06330870
Brain Metastasis Development Mechanism in BCBM Patients No drug interventions screening Not Available recruiting NCT00406835
Prospective Randomized Trial Between WBRT Plus SRS Versus SRS Alone for 1-4 Brain Metastases No drug interventions Not Available Not Available completed NCT06159335
18F-FLUC-CEST PET/MR in Patients With Brain Mets No drug interventions diagnostic 3 recruiting NCT01324635
Panobinostat and Stereotactic Radiation Therapy in Treating Patients With Brain Tumors treatment 1 terminated NCT01727531
IDO2 Genetic Status Informs the Neoadjuvant Efficacy of Chloroquine (CQ) in Brain Metastasis Radiotherapy treatment Not Available completed NCT02448576
PCI in Advanced Triple Negative Breast Cancer Patients Who Response to 1st Line Chemotherapy No drug interventions prevention Not Available not_yet_recruiting NCT01942980
Evaluation of the Efficacy of Hippocampal Avoidance on the Cognitive Toxicity of Whole-Brain Radiation Therapy After Surgical Resection of Single Brain Metastasis of Breast Cancer No drug interventions treatment 3 completed NCT01724801
Icotinib or Whole Brain Irradiation in EGFR-mutant Lung Cancer treatment 3 completed NCT03286023
Stereotactic Radiotherapy for Brain Metastases No drug interventions Not Available Not Available unknown_status NCT06210438
SHR-A1921 Combined With Bevacizumab in Triple-negative Breast Cancer With Brain Metastases treatment 2 not_yet_recruiting NCT02355613
Comparative Evaluation of Two Different Radiosurgery No drug interventions treatment Not Available completed NCT05474573
Concurrent Fluorescence and Sonographically Guided Eradication of Contrast-enhancing Gliomas and Metastases No drug interventions treatment Not Available recruiting NCT05485038
General Anesthesia Versus Awake Surgery in Resection of Gliomas and Metastases of Motor Areas No drug interventions treatment Not Available recruiting NCT05475522
Intraoperative Sonographically Versus Fluorescence-guided Resection of Contrast-enhancing Gliomas and Brain Metastases No drug interventions treatment Not Available recruiting NCT02132598
Trial of Cabozantinib (XL184) in Non-Small Cell Lung Cancer With Brain Metastases treatment 2 terminated NCT01843413
Stereotactic Radiosurgery in Treating Patients With Large Brain Metastases No drug interventions treatment Not Available suspended NCT00992602
Liposomal Cytarabine and High-Dose Methotrexate in Treating Patients With Central Nervous System Metastases From Breast Cancer treatment 2 completed NCT00033254
Radiation Therapy With or Without Thalidomide in Treating Patients With Brain Metastases treatment 3 completed NCT00098605
Lapatinib in Treating Brain Metastases in Patients With Stage IV Breast Cancer and Brain Metastases treatment 2 completed NCT02277561
Voxel Based Diffusion Tensor Imaging in Predicting Response in Patients With Brain Metastases Undergoing Whole Brain Radiation Therapy or Stereotactic Radiosurgery No drug interventions diagnostic Not Available withdrawn NCT02269111
Quantitative MRI in Assessing Disease in Patients With Brain Tumors No drug interventions diagnostic Not Available terminated NCT01703507
Phase I Study of Ipilimumab Combined With Whole Brain Radiation Therapy or Radiosurgery for Melanoma treatment 1 completed NCT00072163
Temozolomide and Thalidomide in Treating Patients With Brain Metastases Secondary to Melanoma treatment 2 completed NCT02312622
Phase 2 Etirinotecan Pegol in Refractory Brain Metastases & Advanced Lung Cancer / Metastatic Breast Cancer treatment 2 completed NCT00937482
Cediranib Maleate and Whole Brain Radiation Therapy in Patients With Brain Metastases From Non-Small Cell Lung Cancer treatment 1 terminated NCT01234740
Bafetinib in Treating Patients With Recurrent High-Grade Glioma or Brain Metastases treatment 1 completed NCT01276210
Sorafenib Tosylate and Stereotactic Radiosurgery in Treating Patients With Brain Metastases treatment 1 completed NCT02107755
Stereotactic Radiation Therapy and Ipilimumab in Treating Patients With Metastatic Melanoma treatment 2 completed NCT01217411
RO4929097 and Whole-Brain Radiation Therapy or Stereotactic Radiosurgery in Treating Patients With Brain Metastases From Breast Cancer treatment 1 terminated NCT01706432
Hypofractionated Image Guided Radiation Therapy in Treating Patients With Stage IV Breast Cancer No drug interventions Not Available Not Available completed NCT01891318
Neoadjuvant Radiosurgery for Resectable Brain Metastases: Phase I/II Study No drug interventions treatment 1 / 2 recruiting NCT02145910
Vemurafenib Combined With Whole Brain Radiation Therapy or Radiosurgery in Patients With BRAF Mutation-Positive Melanoma and Brain Metastases treatment 1 withdrawn NCT04801342
Neurocognitive Outcome of Bilateral or Unilateral Hippocampal Avoidance WBRT With Memantine for Brain Metastases treatment 2 recruiting NCT02038218
Study of 4-Demethyl-4-cholesteryloxycarbonylpenclome (DM-CHOC-PEN) in Patients With Brain Tumors treatment 2 completed NCT02896335
Palbociclib In Progressive Brain Metastases treatment 2 recruiting NCT00928226
Study of Fractionated Stereotactic Radiosurgery to Treat Large Brain Metastases No drug interventions treatment Not Available completed NCT02393131
Neurocognitive Outcome of Conformal WBRT w/wo Hippocampal Avoidance for Brain Metastases No drug interventions treatment Not Available unknown_status NCT02154529
Study of the Combination of KD019 and Trastuzumab in Subjects With HER2-Positive Metastatic Breast Cancer treatment 1 / 2 terminated NCT01332929
Safety Evaluation of a Combination of Brain Radiation Therapy and Bevacizumab (Avastin®) for Treatment of Brain Metastasis treatment 1 completed NCT01705548
Hypofractionated Stereotactic Radiosurgery in Treating Patients With Large Brain Metastasis No drug interventions treatment Not Available completed NCT06500455
Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain No drug interventions treatment 3 recruiting NCT06650163
Zr-89 Crefmirlimab Berdoxam and Immuno-Positron Emission Tomography for the Imaging of Patients With Resectable Brain Tumors No drug interventions diagnostic 1 not_yet_recruiting NCT02015117
Trametinib With or Without Whole Brain Radiation Therapy in Treating Patients With Brain Metastases treatment 1 active_not_recruiting NCT02595905
Cisplatin With or Without Veliparib in Treating Patients With Recurrent or Metastatic Triple-Negative and/or BRCA Mutation-Associated Breast Cancer With or Without Brain Metastases treatment 2 active_not_recruiting NCT02910700
Nivolumab With Trametinib and Dabrafenib, or Encorafenib and Binimetinib in Treating Patients With BRAF Mutated Metastatic or Unresectable Stage III-IV Melanoma treatment 2 active_not_recruiting NCT03087591
APN401 in Treating Patients With Recurrent or Metastatic Pancreatic Cancer, Colorectal Cancer, or Other Solid Tumors That Cannot Be Removed by Surgery No drug interventions treatment 1 completed NCT03873818
Low Dose Ipilimumab with Pembrolizumab in Treating Patients with Melanoma That Has Spread to the Brain treatment 2 active_not_recruiting NCT04588246
Testing the Addition of Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in People With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery treatment 3 terminated NCT05139043
Low Dose Versus Standard Dose Dexamethasone for Reduction of Swelling in Patients with Primary or Metastatic Brain Tumors treatment 2 active_not_recruiting NCT05388877
E6201 and Dabrafenib for the Treatment of Central Nervous System Metastases From BRAF V600 Mutated Metastatic Melanoma treatment 1 recruiting NCT05840770
Cemiplimab for the Treatment of Untreated Brain Metastases From PD-L1 >= 50% Non-Small Cell Lung Cancer treatment 2 recruiting NCT06328686
Arginine and Whole Brain Radiation Therapy for the Treatment of Patients With Brain Metastases No drug interventions treatment 0 recruiting NCT04047264
Feasibility of Intraoperative Microdialysis During Neurosurgery for Central Nervous System Malignancies No drug interventions basic_science Not Available recruiting NCT06137651
Trotabresib in Combination With Vinorelbine and Radiation Therapy for the Treatment of HER2+ Breast Cancer With Central Nervous System or Leptomeningeal Metastasis treatment 1 withdrawn NCT04250545
Testing of the Anti Cancer Drugs CB-839 HCl (Telaglenastat) and MLN0128 (Sapanisertib) in Advanced Stage Non-small Cell Lung Cancer treatment 1 active_not_recruiting NCT04062305
nTMS in Planning Stereotactic Radiosurgery in Patients With Brain Metastases in the Motor Cortex No drug interventions diagnostic Not Available active_not_recruiting NCT03803761
A Study of a New Drug Combination, Copanlisib and Fulvestrant, in Advanced Breast Cancer treatment 1 / 2 withdrawn NCT02360215
Memantine Hydrochloride and Whole-Brain Radiotherapy With or Without Hippocampal Avoidance in Reducing Neurocognitive Decline in Patients With Brain Metastases supportive_care 3 completed NCT04516070
Stereotactic Radiosurgery for the Treatment of Patients With Small Cell Lung Cancer Brain Metastasis No drug interventions treatment 2 active_not_recruiting NCT03520842
Regorafenib and Methotrexate in Treating Participants With Recurrent or Metastatic KRAS Mutated Non-Small Cell Lung Cancer treatment 2 completed NCT05341349
Stereotactic Radiosurgery and Immune Checkpoint Inhibitors With NovoTTF-100M for the Treatment of Melanoma Brain Metastases treatment 1 recruiting NCT04511013
A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases treatment 2 recruiting NCT03994796
Genetic Testing in Guiding Treatment for Patients With Brain Metastases treatment 2 recruiting NCT06315296
An Interactive Time-Restricted Diet Intervention (txt4fasting) for Reducing Neurocognitive Decline and Improving Survival in Patients With Brain Metastases From Breast or Lung Cancer No drug interventions supportive_care Not Available recruiting NCT03685539
DECT in Imaging Patients With Solid Organ Cancer With Intracranial Metastasis No drug interventions diagnostic Not Available completed NCT02589522
Testing the Safety of M6620 (VX-970) When Given With Standard Whole Brain Radiation Therapy for the Treatment of Brain Metastases From Non-small Cell Lung Cancer, Small Cell Lung Cancer, or Neuroendocrine Tumors treatment 1 active_not_recruiting NCT02716948
SRS and Nivolumab in Treating Patients With Newly Diagnosed Melanoma Metastases in the Brain or Spine treatment 1 completed NCT00096265
Radiation Therapy and Stereotactic Radiosurgery With or Without Temozolomide or Erlotinib in Treating Patients With Brain Metastases Secondary to Non-Small Cell Lung Cancer treatment 3 terminated NCT05222620
SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial No drug interventions treatment 2 recruiting NCT03741673
Pre-operative SRS or Post-operative SRS in Treating Cancer Patients With Brain Metastases No drug interventions treatment 3 recruiting NCT01644591
Stereotactic Radiosurgery in Treating Patients With Greater Than 3 Melanoma Brain Metastases No drug interventions treatment 2 active_not_recruiting NCT02967380
Gadobutrol Versus Gadopentetate Dimeglumine or Gadobenate Dimeglumine Before DCE-MRI in Diagnosing Patients With Multiple Sclerosis, Grade II-IV Glioma, or Brain Metastases diagnostic Not Available terminated NCT04804644
Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability supportive_care 3 recruiting NCT02754544
Electrocorticography in Mapping Functional Brain Areas During Surgery in Patients With Brain Tumors No drug interventions diagnostic Not Available recruiting NCT03680144
Utility of Perfusion MRI to Detect Radiation Necrosis in Patients With Brain Metastases No drug interventions diagnostic Not Available completed NCT02971501
Osimertinib With or Without Bevacizumab in Treating Patients With EGFR Positive Non-small Cell Lung Cancer and Brain Metastases treatment 2 active_not_recruiting NCT02167204
18F-FLT PET/CT in Measuring Cell Proliferation in Patients With Brain Tumors No drug interventions diagnostic Not Available completed NCT01592968
Stereotactic Radiosurgery or Whole Brain Radiation Therapy in Treating Patients With Newly Diagnosed Non-melanoma Brain Metastases No drug interventions treatment 3 active_not_recruiting NCT02073968
PET-Adjusted Intensity Modulated Radiation Therapy and Combination Chemotherapy in Treating Patients With Stage II-IV Non-small Cell Lung Cancer treatment 2 completed NCT04789668
Bintrafusp Alfa and Pimasertib for the Treatment of Patients With Brain Metastases treatment 1 / 2 completed NCT05438212
Comparing the Addition of Radiation Either Before or After Surgery for Patients With Brain Metastases No drug interventions treatment 3 recruiting NCT04114981
Single Fraction Stereotactic Radiosurgery Compared With Fractionated Stereotactic Radiosurgery in Treating Patients With Resected Metastatic Brain Disease No drug interventions treatment 3 active_not_recruiting NCT03244995
Mind-Body Intervention in Glioma Couples No drug interventions supportive_care Not Available active_not_recruiting NCT01904123
STAT3 Inhibitor WP1066 in Treating Patients With Recurrent Malignant Glioma or Progressive Metastatic Melanoma in the Brain treatment 1 completed NCT05503251
Neuropsychological Care for Maintaining Quality of Life After Radiation Therapy in Patients With Brain Metastases No drug interventions supportive_care Not Available recruiting NCT05588453
Natural Killer Cell Therapy (UD TGFbetai NK Cells) and Temozolomide for the Treatment of Stage IV Melanoma Metastatic to the Brain treatment 1 / 2 recruiting NCT04348747
Dendritic Cell Vaccines Against Her2/Her3 and Pembrolizumab for the Treatment of Brain Metastasis From Triple Negative Breast Cancer or HER2+ Breast Cancer treatment 2 recruiting NCT05054998
Dual Time Point FDG PET/MRI Scan in Improving the Imaging Cancer Patients With Brain Metastases No drug interventions diagnostic 4 completed NCT03418961
S1501 Carvedilol in Preventing Cardiac Toxicity in Patients With Metastatic HER-2-Positive Breast Cancer supportive_care 3 recruiting NCT02696993
Nivolumab and Radiation Therapy With or Without Ipilimumab in Treating Patients With Brain Metastases From Non-small Cell Lung Cancer treatment 1 / 2 active_not_recruiting NCT05376878
An Investigational Scan (64Cu-DOTA-Trastuzumab PET/MRI) in Imaging Patients With HER2+ Breast Cancer With Brain Metastasis diagnostic 4 recruiting NCT04988009
Patient Perceptions Around Quality of Care Through Telemedicine in Neuro-Oncology No drug interventions Not Available Not Available recruiting NCT04460937
Testing the Addition of an Anti-cancer Drug, Adavosertib, to Radiation Therapy for Patients With Incurable Esophageal and Gastroesophageal Junction Cancers treatment 1 active_not_recruiting NCT03175432
Bevacizumab and Atezolizumab With or Without Cobimetinib in Treating Patients With Untreated Melanoma Brain Metastases treatment 2 active_not_recruiting NCT03270059
Gadolinium and Ferumoxytol MRI in Diagnosing Patients With Abnormalities in the Central Nervous System diagnostic 2 recruiting NCT03071913
Blood Brain Barrier Differences in Patients With Brain Tumors Undergoing Surgery No drug interventions Not Available Not Available completed NCT04585724
Stereotactic Radiosurgery With Abemaciclib, Ribociclib, or Palbociclib in Treating Patients With Hormone Receptor Positive Breast Cancer With Brain Metastases treatment 1 withdrawn NCT04647916
Testing Sacituzumab Govitecan Therapy in Patients With HER2-Negative Breast Cancer and Brain Metastases treatment 2 recruiting NCT03696030
HER2-CAR T Cells in Treating Patients With Recurrent Brain or Leptomeningeal Metastases No drug interventions treatment 1 recruiting NCT04941430
7T MRI Scan for the Early Detection of Melanoma Brain Metastases No drug interventions diagnostic Not Available recruiting NCT00659126
Ferumoxytol- and Gadolinium-Labeled MRI in Measuring Tumors Before or After Treatment in Patients With Primary or Metastatic Brain Tumors diagnostic 2 terminated NCT03750227
Pre-Operative or Post-Operative Stereotactic Radiosurgery in Treating Patients With Operative Metastatic Brain Tumors No drug interventions treatment 3 recruiting NCT02774291
Anti-NY ESO-1 mTCR Peripheral Blood Lymphocytes treatment 0 terminated NCT04631029
Testing the Addition of an Anti-cancer Drug, Entinostat, to the Usual Chemotherapy and Immunotherapy Treatment (Atezolizumab, Carboplatin and Etoposide) for Previously Untreated Aggressive Lung Cancer That Has Spread treatment 1 completed NCT02798029
Frameless Fractionated Stereotactic Radiation in Treating Patients With Brain Metastases No drug interventions treatment 2 completed NCT04895592
Radiosurgery Before Surgery for the Treatment of Brain Metastases treatment 0 recruiting NCT04752267
18F-FMAU PET/CT and MRI for the Detection of Brain Tumors in Patients With Brain Cancer or Brain Metastases diagnostic 0 completed NCT00950001
Stereotactic Radiosurgery Compared to Observation in Treating Patients With Brain Metastases No drug interventions treatment 3 active_not_recruiting NCT01622868
Whole-Brain Radiation Therapy or Stereotactic Radiosurgery With or Without Lapatinib Ditosylate in Treating Patients With Brain Metastasis From HER2-Positive Breast Cancer treatment 2 completed NCT02858869
Pembrolizumab and Stereotactic Radiosurgery for Melanoma or Non-Small Cell Lung Cancer Brain Metastases treatment 1 completed NCT02993146
Ropidoxuridine and Whole Brain Radiation Therapy in Treating Patients With Brain Metastases treatment 1 active_not_recruiting NCT03868423
Brigatinib in Treating Patients With ALK and ROS1 Gene Alterations and Locally Advanced or Metastatic Solid Cancers treatment 2 withdrawn NCT00103038
Ferumoxytol in Improving MR Imaging in Patients With High-Grade Brain Tumors or Cerebral Metastases diagnostic Not Available completed NCT03184038
Neurocognition in Patients With Multiple Brain Metastases Treated With Radiosurgery No drug interventions treatment Not Available recruiting NCT04132843
Novel MRI Techniques for the Characterization and Treatment Assessment of High Grade Brain Lesions diagnostic Not Available completed