NCT06493279
Evaluate the Safety and Efficacy of Intrathecal Injection of RJK002 in Patients With Amyotrophic Lateral Sclerosis No drug interventions treatment 1 not_yet_recruiting NCT06429059
ROAR-DIGAP: A Widely Inclusive, Largely Virtual Pilot Trial Utilizing DIGAP (Deep Integrated Genomics Analysis Platform) To Personalize Treatments treatment 2 enrolling_by_invitation NCT06199284
Atalante Exoskeleton in the Rehabilitation of Patients With Amyotrophic Lateral Sclerosis No drug interventions other Not Available recruiting NCT05852405
Clinical Characteristics, Natural History, Health Care Measures, and Genetic Screening in Patients With ALS No drug interventions Not Available Not Available recruiting NCT04302870
Motor Neurone Disease - Systematic Multi-Arm Adaptive Randomised Trial treatment 2 / 3 recruiting NCT03604822
Music Therapy Protocol to Support Bulbar and Respiratory Functions in ALS No drug interventions health_services_research Not Available unknown_status NCT06320444
Non-invasive Spinal, Cortical, and Sensorimotor Biomarkers in Motor Neurone Disease No drug interventions Not Available Not Available recruiting NCT05299372
Telemonitoring in NIV MND (OptNIVent) No drug interventions supportive_care Not Available unknown_status NCT03537807
Expanded Access Protocol of BHV-0223 for Patients With Amyotrophic Lateral Sclerosis (ALS) Not Available Not Available no_longer_available NCT03520517
Open-label Study to Evaluate Safety, Tolerability and PK of BHV-0223 in ALS No drug interventions treatment 1 completed NCT03100110
NeuroCognitive Communicator: Safety Study No drug interventions device_feasibility Not Available unknown_status NCT03828123
Autologous Multipotent Mesenchymal Stromal Cells in the Treatment of Amyotrophic Lateral Sclerosis No drug interventions treatment 1 / 2 completed NCT02759003
Nightime NIV Initiation in Amyotrophic Lateral Sclerosis in an Outpatient Setting No drug interventions treatment Not Available completed NCT03272503
A Clinical Trial of Pimozide in Patients With Amyotrophic Lateral Sclerosis (ALS) treatment 2 unknown_status NCT03464903
Study of ALS Reversals 2: Genetic Analyses No drug interventions Not Available Not Available completed NCT02405403
Microglial Activation Role In ALS (MARIA) No drug interventions diagnostic 0 withdrawn NCT01495390
A Longitudinal Study of Amyotrophic Lateral Sclerosis (ALS) Biomarkers No drug interventions Not Available Not Available completed NCT03792490
Inhibition of Rho Kinase (ROCK) With Fasudil as Disease-modifying Treatment for ALS treatment 2 completed NCT03150290
Brown Adipose Tissue in ALS No drug interventions other Not Available completed NCT04220190
RAPA-501 Therapy for ALS No drug interventions treatment 2 / 3 not_yet_recruiting NCT02574390
Answer ALS: Individualized Initiative for ALS Discovery No drug interventions Not Available Not Available completed NCT00204464
Study of the Effects Strengthening Exercises in Individuals With ALS No drug interventions treatment 2 completed NCT00386464
Noninvasive Ventilation in ALS Patients With Mild Respiratory Involvement No drug interventions supportive_care 2 / 3 completed NCT06528964
Proteinopathies Expression in Skin of Neurodegenerative Disorders No drug interventions Not Available Not Available recruiting NCT00409721
The Effect of Memantine on Functional Outcomes and Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis (ALS) treatment 2 completed NCT05003921
Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cell Intrathecal Injection for ALS No drug interventions treatment 1 suspended NCT05349721
Study to Assess the Effects of PTC857 Treatment in Participants With Amyotrophic Lateral Sclerosis ALS No drug interventions treatment 2 active_not_recruiting NCT01948102
Identification of Diagnostic And Prognostic Biomarkers From Amyotrophic Lateral Sclerosis (ALS) Skin and Adipose Samples No drug interventions Not Available Not Available completed NCT01459302
Genetic Study of Familial and Sporadic ALS/Motor Neuron Disease, Miyoshi Myopathy and Other Neuromuscular Disorders No drug interventions Not Available Not Available enrolling_by_invitation NCT02479802
Efficacy and Safety of Plasma Exchange With Albumin in Patients With Amyotrophic Lateral Sclerosis treatment 2 completed NCT00337402
Effects of Gastrostomy on Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available completed NCT03851302
Effects of Remote Ischemic Conditioning on Hand Use in Individuals With Spinal Cord Injury and Amyotrophic Lateral Sclerosis No drug interventions basic_science Not Available completed NCT04363684
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) No drug interventions Not Available Not Available recruiting NCT04944784
A Study to Evaluate the Efficacy and Safety of Reldesemtiv in Patients With Amyotrophic Lateral Sclerosis (ALS) treatment 3 terminated NCT05945784
Exploring Accessible Beauty for Individuals With Upper Extremity Deficits No drug interventions Not Available Not Available completed NCT05281484
Two Intermediate Expanded Access Protocols (EAP) CNMAu8.EAP01 and CNMAu8.EAP02 for ALS Not Available Not Available available NCT06083584
Development of Targeted RNA-Seq for Amyotrophic Lateral Sclerosis Diagnosis No drug interventions Not Available Not Available recruiting NCT01592084
Hyperlipidemia and Statin Therapy in Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available completed NCT03945279
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BIIB100 Administered Orally to Adults With Amyotrophic Lateral Sclerosis No drug interventions treatment 1 completed NCT05067179
Analysis of Human ALS Tissues and Registry of ALS Patients No drug interventions Not Available Not Available recruiting NCT02572479
Evaluating the Potential of the Diet as Disease Modifier in Amyotrophic Lateral Sclerosis (JERN_ALS) No drug interventions Not Available Not Available completed NCT05974579
Safety and Dosimetry of a New Radiotracer to Detect Misfolded SOD1 Associated With Amyotrophic Lateral Sclerosis No drug interventions diagnostic 1 recruiting NCT00372879
Clinical Trial of Vitamin E to Treat Muscular Cramps in Patients With ALS No drug interventions treatment 3 completed NCT05297487
Evaluation of the Early Use of the Pressure Relaxer in the Respiratory Impairment of Patients With Amyotrophic Lateral Sclerosis: Multicenter Randomized Controlled Study. No drug interventions other Not Available not_yet_recruiting NCT03912987
TRIAL READY (Clinical Trial Readiness) No drug interventions Not Available Not Available active_not_recruiting NCT04950933
The Treatment of Amyotrophic Lateral Sclerosis With Huollingshengji Granules treatment 2 / 3 unknown_status NCT00839033
Evaluation of a Mechanical Device During Acute Respiratory Failure in Patients With Neuromuscular Disorders No drug interventions treatment 3 terminated NCT00011154
Exogenous Toxicants and Genetic Susceptibility in ALS No drug interventions Not Available Not Available completed NCT03068754
Study of Acthar® Gel (Acthar) for Amyotrophic Lateral Sclerosis (ALS) treatment 2 / 3 terminated NCT03757351
Study to Evaluate DNL747 in Subjects With Amyotrophic Lateral Sclerosis No drug interventions treatment 1 terminated NCT01348451
Human Spinal Cord Derived Neural Stem Cell Transplantation for the Treatment of Amyotrophic Lateral Sclerosis No drug interventions treatment 1 unknown_status NCT01082653
Safety/Efficacy Study for the Treatment of Amyotrophic Lateral Sclerosis No drug interventions diagnostic 1 suspended NCT00886977
Efficacy and Safety of YAM80 in Amyotrophic Lateral Sclerosis (ALS) No drug interventions treatment 2 unknown_status NCT03944447
Outcomes Mandate National Integration With Cannabis as Medicine treatment 2 recruiting NCT00706147
Phase II/III Randomized, Placebo-controlled Trial of Arimoclomol in SOD1 Positive Familial Amyotrophic Lateral Sclerosis treatment 2 / 3 completed NCT03806647
Development and Needs Assessment and Efficiency of Smart Communication System for Patients With ALS (Part 1) No drug interventions Not Available Not Available unknown_status NCT04797845
Patient's TeleMonitoring With Amyotrophic Lateral Sclerosis Treated by Non Invasive Ventilation at Home. No drug interventions other Not Available completed NCT04788745
Targeting Metabolic Flexibility in Amyotrophic Lateral Sclerosis (ALS) treatment 2 completed NCT06391645
Nerve Growth Factor Encapsulated With 2-methacryloyloxyethyl Phosphorylcholine Nanocapsules in the Treatment of Amyotrophic Lateral Sclerosis treatment 2 / 3 not_yet_recruiting NCT00159198
Amyotrophic Lateral Sclerosis and Frontotemporal Dementia No drug interventions Not Available Not Available terminated NCT04889898
Remote Speech and Swallowing Assessment in ALS No drug interventions Not Available Not Available recruiting NCT04332198
Neurobiological and Immunological Mechanisms of Dyspnea in ALS (BIOPNEA) No drug interventions other Not Available not_yet_recruiting NCT00302198
Amyotrophic Lateral Sclerosis Web Based Patient Care Database: ALSConnection.Org No drug interventions Not Available Not Available completed NCT02893605
Study of Gene Polymorphisms Involved in the Metabolism and Action of Vitamin D in Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available completed NCT03652805
A Study of IPL344 in the Treatment of ALS Patients treatment 1 / 2 suspended NCT04998305
TJ-68 Clinical Trial in Patients With Amyotrophic Lateral Sclerosis (ALS) and Muscle Cramps No drug interventions treatment 1 / 2 active_not_recruiting NCT00021697
Safety/Efficacy of AVP-923 in the Treatment of Emotional Lability (Uncontrolled Crying & Laughing) in Patients With ALS No drug interventions treatment 3 completed NCT02988297
Nebulized RNS60 for the Treatment of Amyotrophic Lateral Sclerosis No drug interventions treatment 2 not_yet_recruiting NCT04436497
HEALEY ALS Platform Trial - Regimen A Zilucoplan treatment 2 / 3 completed NCT04297683
HEALEY ALS Platform Trial - Master Protocol treatment 2 / 3 active_not_recruiting NCT01154283
Study of Standard Noninvasive Positive Pressure Ventilation (NIPPV) and Low Expiratory Pressure NIPPV in ALS Patients No drug interventions treatment Not Available completed NCT01285583
Safety Extension Study of TRO19622 in ALS Not Available 2 / 3 completed NCT00983983
High Fat/High Calorie Trial in Amyotrophic Lateral Sclerosis No drug interventions treatment 2 completed NCT04798183
Geometrical Facial Deformation According to Posture in Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available unknown_status NCT05619783
Extension Study Evaluating The Safety And Tolerability of AMX0035 treatment 3 enrolling_by_invitation NCT05498883
Quality of Life Evaluation With the SRI Questionnaire of ALS Patient With Non-invasive Ventilation No drug interventions supportive_care Not Available recruiting NCT06581861
PREVENT ALL ALS Study No drug interventions Not Available Not Available recruiting NCT06284161
QCT in ALS Diagnosis, Mechanistic Understanding and Follow-up No drug interventions diagnostic Not Available recruiting NCT02645461
Acetylcholine Receptors From Human Muscles as Pharmacological Target for ALS basic_science Not Available completed NCT04391361
The Safety and Effectiveness of Cholinergic Receptor Block Therapy in the Treatment of ALS treatment 2 unknown_status NCT01521728
Trial of Resistance and Endurance Exercise in Amyotrophic Lateral Sclerosis (ALS) No drug interventions supportive_care Not Available completed NCT05407428
A Prospective Study to Evaluate the Correlation Between Oculometric Measurements and Clinical Endpoints in ALS Patients No drug interventions Not Available Not Available recruiting NCT03548311
Clinical Trial of Ultra-high Dose Methylcobalamin for ALS treatment 3 unknown_status NCT05983211
Quantitative and Repetitive TMS in ALS - Recruiting for Stage 2 No drug interventions treatment Not Available recruiting NCT00718393
Compassionate Use of Ceftriaxone in Patients With Amyotrophic Lateral Sclerosis (ALS) No drug interventions Not Available Not Available completed NCT02193893
Biological Treatment of Amyotrophic Lateral Sclerosis No drug interventions treatment 1 unknown_status NCT05176093
A 6-Month Extension Study to Assess the Long-Term Safety of Engensis in Amyotrophic Lateral Sclerosis treatment 2 completed NCT02242071
Cell Therapy for Motor Neuron Disease/Amyotrophic Lateral Sclerosis No drug interventions treatment 1 withdrawn NCT00004771
Phase II Study of Leuprolide and Testosterone for Men With Kennedy's Disease or Other Motor Neuron Disease treatment 2 completed NCT00753571
Cistanche Total Glycosides for Amyotrophic Lateral Sclerosis: A Randomized Control Trial (RCT) Study Assessing Clinical Response No drug interventions treatment 2 unknown_status NCT03948178
Effects of Oral Levosimendan on Respiratory Function in Patients With Amyotrophic Lateral Sclerosis (ALS): Open-Label Extension treatment 3 terminated NCT04820478
Efficacy and Tolerability of Beta Hydroxybutyrate Ester in Patients With Amyotrophic Lateral Sclerosis (ALS) No drug interventions treatment Not Available recruiting NCT01449578
Dexpramipexole SAD/MAD Study treatment 1 completed NCT04798378
NuroSleeve Powered Brace & Stimulation System to Restore Arm Function No drug interventions supportive_care Not Available recruiting NCT06337578
Advances in Telephone-based Cognitive Screening Procedures No drug interventions Not Available Not Available recruiting NCT03489278
Clinical Procedures to Support Research in ALS No drug interventions Not Available Not Available recruiting NCT05979688
Yogic Breathing Exercise for People With Amyotrophic Lateral Sclerosis No drug interventions treatment Not Available recruiting NCT01622088
Phase 3 Extension Study of Dexpramipexole in ALS treatment 3 terminated NCT00718107
Satisfaction Survey for Amyotrophic Lateral Sclerosis (ALS) Patients Comparing Rooms With and Without Assistive Technology No drug interventions Not Available Not Available terminated NCT02487407
Effects of ODM-109 on Respiratory Function in Patients With Amyotrophic Lateral Sclerosis treatment 2 completed NCT05837507
Amyotrophic Lateral Sclerosis Non-invasive Ventilation Exchange No drug interventions treatment Not Available recruiting NCT03377309
Safety and Tolerability of Perampanel in Amyotrophic Lateral Sclerosis Patients treatment 2 terminated NCT02874209
Noninvasive Assessment of Neuronal Damage by MRI Sodium ( 23Na ) in Amyotrophic Lateral Sclerosis No drug interventions diagnostic Not Available unknown_status NCT04150809
A Study to Explore the Role of Gut Flora in ALS No drug interventions Not Available Not Available unknown_status NCT04559009
COVID-19 Amyotrophic Lateral Sclerosis (ALS) Registry No drug interventions Not Available Not Available completed NCT01504009
Muscle Training of Patients With Amyotrophic Lateral Sclerosis (ALS) No drug interventions treatment Not Available completed NCT01142856
Mesenchymal Stem Cells for Treatment of Amyotrophic Lateral Sclerosis (ALS) No drug interventions treatment 1 completed NCT05951556
Telehealth Implementation of Brain-Computer Interface No drug interventions supportive_care Not Available recruiting NCT04494256
A Study to Assess the Safety, Tolerability, and Effect on Disease Progression of BIIB105 in Participants With Amyotrophic Lateral Sclerosis (ALS) and Participants With the ALS Ataxin-2 (ATXN2) Genetic Mutation No drug interventions treatment 1 / 2 active_not_recruiting NCT06318585
Creation of a Clinical Database for the Study of Phenotypic Variability in Motor Neuron Diseases No drug interventions Not Available Not Available recruiting NCT02582385
In-situ Cytokines Expression in the CNS in Amyotrophic Lateral Sclerosis (ALS) No drug interventions Not Available Not Available completed NCT00596115
Treating Amyotrophic Lateral Sclerosis (ALS) With R(+) Pramipexole Dihydrochloride Monohydrate at 60 mg/Day Not Available Not Available temporarily_not_available NCT06209515
Sociodemographic Factors and Criminal Behaviour Preceding Neurodegenerative Disease - Retrospective Register Study No drug interventions Not Available Not Available active_not_recruiting NCT03103815
Trial of Amivita in Amyotrophic Lateral Sclerosis No drug interventions treatment Not Available unknown_status NCT03114215
Effect of MD1003 in Amyotrophic Lateral Sclerosis other 2 completed NCT06126315
Trial on the Biological and Clinical Effects of Acetyl-L-carnitine in ALS treatment 2 / 3 not_yet_recruiting NCT03694132
Brain Excitability and Connectivity in Sensory-motor Pathways in ALS No drug interventions basic_science Not Available unknown_status NCT00243932
Clinical Trial of High Dose CoQ10 in ALS treatment 2 completed NCT04082832
CuATSM Compared With Placebo for Treatment of ALS/MND treatment 2 / 3 unknown_status NCT04744532
iPSC-based Drug Repurposing for ALS Medicine (iDReAM) Study treatment 1 / 2 recruiting NCT04514952
Individual Patient Expanded Access IND of Autologous HBadMSCs for the Treatment of Amyotrophic Lateral Sclerosis Not Available Not Available no_longer_available NCT00140452
Phase II Study Using Thalidomide for the Treatment of ALS treatment 2 completed NCT02795052
Neurologic Stem Cell Treatment Study No drug interventions treatment Not Available recruiting NCT00855400
Clinical Trial on the Use of Autologous Bone Marrow Stem Cells in Amyotrophic Lateral Sclerosis No drug interventions treatment 1 / 2 completed NCT00136500
Clinical Research in ALS Study No drug interventions Not Available Not Available recruiting NCT01954875
Establishment of a Human Tissue Bank for Studying the Microbial Etiology of Neurodegenerative Diseases No drug interventions Not Available Not Available withdrawn NCT04328675
Registration Study of Amyotrophic Lateral Sclerosis (ALS) in Mainland China No drug interventions Not Available Not Available unknown_status NCT02675075
DESIPHER_Speech Degradation as an Indicator of Physiological Degeneration in ALS No drug interventions Not Available Not Available completed NCT02325375
sCD163 in ALS Patients No drug interventions Not Available Not Available completed NCT05442775
A Phase 3, Open-Label Extension of COURAGE-ALS (CY 5031) treatment 3 terminated NCT03378375
Resting Energy Expenditure Equations in Amyotrophic Lateral Sclerosis, Creation of a ALS-specific Equation No drug interventions Not Available Not Available completed NCT00613899
Feasibility of Telesurveillance and Home Cough Assistance for Amyotrophic Lateral Patients (ALS) No drug interventions treatment 4 completed NCT02623699
An Efficacy, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of BIIB067 (Tofersen) in Adults With Inherited Amyotrophic Lateral Sclerosis (ALS) treatment 3 completed NCT03324399
A Study of Protein Metabolism, Microbiome and Investigational Probiotic Use in Patients With ALS No drug interventions treatment Not Available completed NCT04233099
Salivary Biomarker Discovery by Raman Spectroscopy in ALS (SalivALS) No drug interventions Not Available Not Available recruiting NCT03085706
Transplantation of Autologous Peripheral Blood Mononuclear Cells for Amyotrophic Lateral Sclerosis No drug interventions treatment Not Available completed NCT04098406
Therapeutic Nanocatalysis to Slow Disease Progression of Amyotrophic Lateral Sclerosis (ALS) treatment 2 completed NCT05189106
Neurodegenerative Alzheimer's Disease and Amyotrophic Lateral Sclerosis (NADALS) Basket Trial treatment 1 / 2 recruiting NCT04380649
Development and Test of a Headset for BCI Until Obtaining an Efficient and Comfortable System That Can be Used in Daily Practice by ALS People No drug interventions other Not Available recruiting NCT04322149
Multiple Doses of AT-1501-A201 in Adults With ALS treatment 2 completed NCT06551649
Human Amniotic Mesenchymal Cell Secretome for Neurodegeneration and Neuroinflammation No drug interventions basic_science Not Available not_yet_recruiting NCT01536249
Dexpramipexole and Cimetidine Drug Drug Interaction (DDI) treatment 1 completed NCT06008249
Platform Trial to Assess the Efficacy of Multiple Drugs in Amyotrophic Lateral Sclerosis (ALS) treatment 3 recruiting NCT02714036
A Biomarker Study to Evaluate MN-166 (Ibudilast) in Subjects With Amyotrophic Literal Sclerosis (ALS) treatment 1 / 2 completed NCT04947436
ALS and Airway Clearance (ALSAC) Therapy No drug interventions treatment Not Available completed NCT00036413
A 12-week, Multicenter, Safety and Dose-ranging Study of 3 Oral Doses of TCH346 in Patients With Amyotrophic Lateral Sclerosis treatment 2 completed NCT02000713
Cervical Spinal Cord Metabolism and Microstructure in Amyotrophic Lateral Sclerosis(ALS) No drug interventions diagnostic Not Available terminated NCT03567213
Investigation on the Cortical Communication (CortiCom) System No drug interventions device_feasibility Not Available recruiting NCT00690118
Study of Pioglitazone in Patients With Amyotrophic Lateral Sclerosis treatment 2 terminated NCT00140218
R(+) Pramipexole in Early Amyotrophic Lateral Sclerosis treatment 1 / 2 completed NCT04468919
Optimizing BCI-FIT: Brain Computer Interface - Functional Implementation Toolkit No drug interventions basic_science Not Available recruiting NCT00537641
Efficacy of Noninvasive Ventilation in Amyotrophic Lateral Sclerosis (ALS) No drug interventions Not Available Not Available completed NCT00912041
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia No drug interventions other Not Available recruiting NCT03237741
Bioavailability of GDC-0134 and the Effect of Food and Proton Pump Inhibitor on Pharmacokinetics of GDC-0134 in Healthy Female Participants treatment 1 completed NCT04721717
AIM's Writing for Healing: A Workshop for Individuals Living With Paralysis No drug interventions Not Available Not Available recruiting NCT00838617
Muscle Ultrasound: A New Tool for Measuring Progression in Amyotrophic Lateral Sclerosis (ALS) No drug interventions Not Available Not Available completed NCT03034317
NeuRx Diaphram Pacing System (DPS) Use in Amyotrophic Lateral Sclerosis (ALS) No drug interventions treatment Not Available withdrawn NCT03579017
Edinburgh Cognitive and Behavioural Amyotrophic Lateral Sclerosis Screen in Norway: A Validation Study No drug interventions Not Available Not Available unknown_status NCT03488524
Open Label Extension Study of AMX0035 in Patients With ALS No drug interventions treatment 2 completed NCT05407324
Dazucorilant in Patients With Amyotrophic Lateral Sclerosis treatment 2 active_not_recruiting NCT00213824
A Study of the Expression of Nogo and Reticulon Genes in Skeletal Muscle of Patients With Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available terminated NCT04953624
Appetite and Related Factors in Patients With ALS No drug interventions Not Available Not Available unknown_status NCT06365216
ALS Phase II Study of NX210c No drug interventions treatment 2 not_yet_recruiting NCT02492516
Intravenous Injection of Adipose Derived Mesenchymal Stem Cell for ALS No drug interventions treatment 1 completed NCT01730716
Dose Escalation and Safety Study of Human Spinal Cord Derived Neural Stem Cell Transplantation for the Treatment of Amyotrophic Lateral Sclerosis No drug interventions treatment 2 unknown_status NCT03836716
Arimoclomol in Amyotropic Lateral Sclerosis - Open Label Extension Trial treatment 3 terminated NCT04875416
Phenotype, Genotype and Biomarkers 2 No drug interventions Not Available Not Available recruiting NCT04516096
A Compassionate Use Protocol of AMX0035 for Treatment of Patients With Amyotrophic Lateral Sclerosis (ALS) No drug interventions treatment 2 / 3 completed NCT03578796
Edinburgh Cognitive and Behavioural Amyotrophic Lateral Sclerosis Screen in Norway: A Prospective Cohort Study No drug interventions Not Available Not Available unknown_status NCT00647296
Safety and Tolerability Study of KNS-760704 in Amyotrophic Lateral Sclerosis (ALS) treatment 2 completed NCT04089696
Validation of the "ExSpiron©" in Patients With ALS No drug interventions basic_science Not Available not_yet_recruiting NCT02469896
A Trial of Tocilizumab in ALS Subjects treatment 2 completed NCT04097158
Biomarkers in Different Types of Amyotrophic Lateral Sclerosis (ALS) Patients Being Treated With Edaravone No drug interventions Not Available Not Available recruiting NCT05352958
Contribution of Diaphragmatic Ultrasound for Monitoring Diaphragmatic Function in Patients With Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available recruiting NCT05105958
Tideglusib for the Treatment of Amyotrophic Lateral Sclerosis treatment 2 not_yet_recruiting NCT03192358
Physiological Flow of Liquids Used in Dysphagia Management (Neuro) No drug interventions Not Available Not Available completed NCT04569435
Study of ANX005 in Adults With Amyotrophic Lateral Sclerosis (ALS) treatment 2 completed NCT05474235
Studies in Amyotrophic Lateral Sclerosis (ALS) and Other Neurodegenerative Motor Neuron Disorders No drug interventions Not Available Not Available recruiting NCT01424163
Dexpramipexole Japanese PK Study No drug interventions basic_science 1 completed NCT03411863
Cervical Electrical Stimulation for ALS No drug interventions basic_science Not Available completed NCT03474263
IC14 for Rapidly Progressive Amyotrophic Lateral Sclerosis (ALS) No drug interventions treatment 2 withdrawn NCT04499963
Trial of Theracurmin for Patients With Amyotrophic Lateral Sclerosis (ALS) No drug interventions treatment 2 completed NCT03892863
Repetitive Transcranial Magnetic Stimulation as Therapy for Depression in Amyotrophic Lateral Sclerosis No drug interventions treatment Not Available withdrawn NCT05163886
Study of Safety, Tolerability, and Biological Activity of LAM-002A in C9ORF72-Associated Amyotrophic Lateral Sclerosis No drug interventions treatment 2 active_not_recruiting NCT03334786
Study to Evaluate Safety & Efficacy of FLX-787-ODT to Treat Fasciculations in Tongue and Appendicular Muscle in Adult Subjects With ALS No drug interventions treatment 1 / 2 terminated NCT03427086
Safety and Tolerability of High Dose Biotin in Patients With Amyotrophic Lateral Sclerosis treatment 2 completed NCT04953286
Ocular Surface Metabolo-lipidomics in Lateral Amyotrophic Sclerosis No drug interventions health_services_research Not Available completed NCT03073239
Amyotrophic Lateral Sclerosis: a New Paradigm No drug interventions Not Available Not Available completed NCT04956822
Application of Motor Unit Estimation Index in Amyotrophic Lateral Sclerosis and Related Diseases No drug interventions Not Available Not Available unknown_status NCT01016522
Safety and Tolerability of the Ketogenic Diet in Amyotrophic Lateral Sclerosis (ALS) No drug interventions treatment 3 terminated NCT06527222
A Study of Ranolazine in ALS treatment 2 not_yet_recruiting NCT00007722
Amyotrophic Lateral Sclerosis (ALS) Gulf War Study No drug interventions Not Available Not Available completed NCT03659422
Dietary Approach to Improving Quality of Life in Amyotrophic Lateral Sclerosis No drug interventions treatment Not Available withdrawn NCT00349622
Clinical Trial Ceftriaxone in Subjects With ALS treatment 3 completed NCT05892822
Amyotrophic Lateral Sclerosis Registry No drug interventions Not Available Not Available not_yet_recruiting NCT00326625
Clinical Trial of Glatiramer Acetate in Amyotrophic Lateral Sclerosis (ALS) treatment 2 completed NCT04952025
Quantitative Analysis of Precise Brain Volume in Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available completed NCT01911130
Longitudinal Study of Outcomes Measures in ALS Trials No drug interventions Not Available Not Available completed NCT01123148
A P300 Brain Computer Interface to Operate Power Wheelchair Tilt No drug interventions supportive_care Not Available completed NCT06441448
potentiALS - Quality of Life Among Patients With Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available recruiting NCT04889248
Inspiratory Muscle Training With Powerbreath Device in Patients With ALS No drug interventions supportive_care Not Available completed NCT05306457
CNS10-NPC-GDNF Delivered to the Motor Cortex for ALS No drug interventions treatment 1 recruiting NCT05632757
Anticipated Patient and Caregiver Burden No drug interventions supportive_care Not Available recruiting NCT02794857
Safety and Efficacy Study of NP001 in Patients With Amyotrophic Lateral Sclerosis (ALS) and Systemic Inflammation No drug interventions treatment 2 completed NCT06181526
Safety and Preliminary Efficacy of Aleeto in Amyotrophic Lateral Sclerosis No drug interventions treatment 1 not_yet_recruiting NCT04800926
Xavier Electromyographic Wheelchair Control for Limited Mobility Patients No drug interventions device_feasibility Not Available completed NCT02916966
Environmental Exposure and Neurological Diseases Questionnaire No drug interventions Not Available Not Available completed NCT04313166
Treatment Continuation Study for Patients With ALS/MND Who Completed Study CMD-2019-001 treatment 2 completed NCT00561366
A Multicenter, Double-Blind Study to Investigate the Safety and Efficacy of Arimoclomol in Volunteers With ALS treatment 2 withdrawn NCT00868166
Safety and Efficacy of TRO19622 as add-on Therapy to Riluzole Versus Placebo in Treatment of Patients Suffering From ALS other 3 completed NCT03573466
Presymptomatic Neuromuscular Junction Defects and Compensatory Mechanisms in ALS No drug interventions basic_science Not Available unknown_status NCT05137665
Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures No drug interventions Not Available Not Available recruiting NCT01641965
Impact of Early Non Invasive Ventilation in Amyotrophic Lateral Sclerosis (ALS) Patients No drug interventions treatment Not Available completed NCT05716074
The Effect of Low-İntensity Combined Exercises in Patients With Early Stage ALS. No drug interventions treatment Not Available recruiting NCT05508074
Treatment Combining Riluzole and IFB-088 in Bulbar Amyotrophic Lateral Sclerosis (TRIALS Protocol) treatment 2 active_not_recruiting NCT01786174
Gilenya in Amyotrophic Lateral Sclerosis (ALS) treatment 2 completed NCT04885374
China Amyotrophic Lateral Sclerosis Registry of Patients With Traditional Chinese Medicine No drug interventions Not Available Not Available recruiting NCT06454682
An IIT Clinical Study to Evaluate the Safety and Efficacy of a Single Intrathecal Injection of RJK002 in Patients With Amyotrophic Lateral Sclerosis (ALS) No drug interventions treatment 0 not_yet_recruiting NCT01051882
Autologous Cultured Mesenchymal Bone Marrow Stromal Cells Secreting Neurotrophic Factors (MSC-NTF), in ALS Patients. No drug interventions treatment 1 / 2 completed NCT03892382
Repetitive Transcranial Magnetic Stimulation as Therapy for Apathy in Amyotrophic Lateral Sclerosis No drug interventions treatment Not Available withdrawn NCT00790582
A Multi-Center Controlled Screening Trial of Safety and Efficacy of Lithium Carbonate in Subjects With Amyotrophic Lateral Sclerosis (ALS) treatment 2 completed NCT06441682
A Safety and Efficacy Study of ARGX-119 in Adult Patients With Amyotrophic Lateral Sclerosis (ALS) treatment 2 not_yet_recruiting NCT04950231
Investigation on Home Care Needs of ALS Patients and Their Caregivers No drug interventions Not Available Not Available completed NCT06315673
Digital Assessment of Speech and Fine Motor Control in ALS No drug interventions Not Available Not Available recruiting NCT03039673
MIROCALS: Modifying Immune Response and OutComes in ALS treatment 2 completed NCT00600873
R(+)PPX High Dose Treatment of ALS Not Available 1 / 2 completed NCT01959373
Dysfunctions and Plasticity Mechanisms of Motor System Assessed by Cortico-cortical and Cortico-muscular Coherence Analysis in Amyotrophic Lateral Sclerosis No drug interventions diagnostic Not Available suspended NCT04104373
The Ontario Neurodegenerative Disease Research Initiative No drug interventions Not Available Not Available completed NCT06408727
Intermediate Expanded Access Protocol CNMAu8.EAP04 Not Available Not Available available NCT02118727
Therapy in Amyotrophic Lateral Sclerosis (TAME) treatment 2 completed NCT04575727
Exploratory Evaluation of [11C]MPC6827 No drug interventions basic_science 0 recruiting NCT06169176
RAPA-501 Therapy for ALS Expanded Access Protocol No drug interventions Not Available Not Available available NCT02590276
Predict to Prevent Frontotemporal Lobar Degeneration (FDT) and Amyotrophic Lateral Sclerosis (ALS) No drug interventions prevention Not Available completed NCT01378676
A Study to Evaluate the Effects of Multiple Doses of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS) treatment 2 completed NCT00846560
Involvement of Lymphocyte Type B in Amyotrophic Lateral Sclerosis (ALS) No drug interventions Not Available Not Available withdrawn NCT05336760
Dysphagia, QoL and Attitudes Towards PEG in ALS Patients No drug interventions Not Available Not Available recruiting NCT05340660
mGluR5 Imaging in ALS Using PET No drug interventions basic_science Not Available recruiting NCT06344260
Neural Stem Cell Treatment for Amyotrophic Lateral Sclerosis (STEMALS) No drug interventions treatment 2 recruiting NCT04953494
Pleiotropy and Mechanism of Peripheral Nerve Related Genes in the Progression of Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available unknown_status NCT05193994
Triumeq in Amyotrophic Lateral Sclerosis treatment 3 recruiting NCT03293394
Rehabilitative Trial With tDCS in Amyotrophic Lateral Sclerosis No drug interventions treatment Not Available completed NCT05949294
Study of AROSOD-1 in Adult Participants With Amyotrophic Lateral Sclerosis (ALS) No drug interventions treatment 1 withdrawn NCT03690791
Efficacy of Cannabinoids in Amyotrophic Lateral Sclerosis or Motor Neurone Disease No drug interventions treatment 3 active_not_recruiting NCT02360891
Study of Predictive Factors of Progression of Motor Neurone Disease No drug interventions Not Available Not Available recruiting NCT02288091
A Pilot Study of Inosine in Amyotrophic Lateral Sclerosis (ALS) treatment 1 completed NCT03201991
ALS Study Determining Various Biomarkers and Strength Comparison After Exercise No drug interventions prevention Not Available completed NCT01639391
Creation of a Bank of Fibroblast From Patients With Amyotrophic Lateral Sclerosis: Pilot Study No drug interventions basic_science Not Available completed NCT04468191
Fatigue in Patients With Amyotrophic Lateral Sclerosis No drug interventions treatment Not Available withdrawn NCT01508962
PRE-Symptomatic Studies in Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available active_not_recruiting NCT01384162
An Open Label, Safety and Tolerability Continuation Study of Intracerebroventricular Administration of sNN0029 to Patients With Amyotrophic Lateral Sclerosis treatment 1 / 2 terminated NCT06230562
DIAGALS: Relation Between Tar DNA Binding Protein(TDP)-43 et Nrf-2 in ALS: a Track to Improve Diagnosis and Prognosis of the Disease No drug interventions diagnostic Not Available not_yet_recruiting NCT03536962
Multidisciplinary Follow-up of Patients With Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available unknown_status NCT02868580
Safety and Tolerability of Antiretroviral (Triumeq) in Patients With Amyotrophic Lateral Sclerosis (ALS). treatment 2 completed NCT01823380
Influence of the Vitamin D Blood Levels on the Amyotrophic Lateral Sclerosis Phenotype No drug interventions basic_science Not Available completed NCT01494480
The Clinical Trial on the Use of Umbilical Cord Mesenchymal Stem Cells in Amyotrophic Lateral Sclerosis No drug interventions treatment 2 unknown_status NCT03095729
Cognitive Consequences of an Activation of the Cortical Drive to Breath (VENTIPSY) No drug interventions Not Available Not Available completed NCT01992029
Study of miRNA Expression Pattern as Diagnostic and Prognostic Biomarker in Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available terminated NCT04762589
RT001 in Amyotrophic Lateral Sclerosis treatment 2 unknown_status NCT01281189
Phase 3 Study of Dexpramipexole in ALS treatment 3 completed NCT04654689
Impact of the Combined Treatment of Liposomed Polyphenols With G04CB02 on the ALS Patients No drug interventions supportive_care 2 completed NCT02881489
Autologous Bone Marrow Mesenchymal Stem Cells in the Treatment of Patients With Amyotrophic Lateral Sclerosis No drug interventions treatment 1 unknown_status NCT04454892
Natural History and Clinical Features of Amyotrophic Lateral Sclerosis (ALS) No drug interventions Not Available Not Available recruiting NCT05328492
Volume Mode Non-invasive Ventilation in Amyotrophic Lateral Sclerosis No drug interventions treatment Not Available recruiting NCT05860244
Effect of Salbutamol on Walking Capacity in Ambulatory ALS Patients treatment 2 not_yet_recruiting NCT00931944
Open-Label, Safety and Tolerability Extension Study of KNS-760704 in Amyotrophic Lateral Sclerosis (ALS) (CL211) treatment 2 completed NCT04066244
Study of Safety and of the Mechanism of BLZ945 in ALS Patients treatment 2 terminated NCT04226144
Breath Stacking Technique Associated With Expiratory Muscle Training in Amyotrophic Lateral Sclerosis Patients No drug interventions treatment Not Available terminated NCT03225144
Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia No drug interventions Not Available Not Available recruiting NCT04440644
Italian Validation of the Beaumont Behavioural Inventory (BBI) No drug interventions Not Available Not Available completed NCT05981040
Efficacy, Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ZYIL1 in Patients With Amyotrophic Lateral Sclerosis treatment 2 active_not_recruiting NCT01160367
Trial of Ascertaining Individual Preferences for Loved One's Role in End-of-Life No drug interventions supportive_care Not Available completed NCT04393467
Transcranial Static Magnetic Field Stimulation (tSMS) in Amyotrophic Lateral Sclerosis (ALS). No drug interventions treatment Not Available unknown_status NCT03127267
Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients treatment 3 recruiting NCT00956501
Assessment of Postural Orientation and Equilibrium In Early Amyotrophic Lateral Sclerosis (ALS) No drug interventions Not Available Not Available completed NCT00877604
Efficacy and Tolerability of Tauroursodeoxycholic Acid in Amyotrophic Lateral Sclerosis treatment 2 completed NCT04882904
Continuous Measurement of Activity in Patients With Muscle Pathology and in Control Subjects. ActiSLA Part. No drug interventions other Not Available recruiting NCT06165172
Early Feasibility Study of the MyoRegulator® for Treatment of ALS No drug interventions device_feasibility Not Available recruiting NCT04768972
FUSION: A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of ION363 in Amyotrophic Lateral Sclerosis Participants With Fused in Sarcoma Mutations (FUS-ALS) treatment 3 recruiting NCT05286372
An Intermediate Size Expanded Access Protocol of AMX0035 for ALS No drug interventions Not Available Not Available approved_for_marketing NCT05889572
Safety and Gut Microbiota Analysis of an Oral Microbiotherapy in Patients With Amyotrophic Lateral Sclerosis No drug interventions treatment 1 active_not_recruiting NCT03929068
Sinemet for Spasticity and Function in Amyotrophic Lateral Sclerosis and Primary Lateral Sclerosis treatment 1 completed NCT00677768
Validation of Biomarkers in Amyotrophic Lateral Sclerosis (ALS) No drug interventions Not Available Not Available completed NCT05106569
Telespirometry in Amyotrophic Lateral Sclerosis (ALS) No drug interventions Not Available Not Available enrolling_by_invitation NCT06539169
FLOWER: Following Longitudinal Outcomes With Epidemiology for Rare Diseases No drug interventions Not Available Not Available recruiting NCT01955369
Amyotrophic Lateral Sclerosis Registry Rhineland-Palatinate No drug interventions Not Available Not Available completed NCT06513546
A Study to Evaluate the Safety, Efficacy, and Pharmacodynamics of PLL001 in ALS Patients treatment 1 / 2 not_yet_recruiting NCT04948346
Correlation Between Intestinal Microflora Metabolites and Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available completed NCT06418646
Patients' and Caregivers' Views of Multidimensional Care in Amyotropic Lateral Sclerosis in Germany No drug interventions Not Available Not Available recruiting NCT03049046
CC100: Phase 1 Multiple-Dose Safety and Tolerability in Subjects With ALS No drug interventions treatment 1 unknown_status NCT00875446
First Time in Human Study of GSK1223249 in Amyotrophic Lateral Sclerosis treatment 1 completed NCT03626012
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of BIIB078 in Adults With C9ORF72-Associated Amyotrophic Lateral Sclerosis No drug interventions treatment 1 completed NCT01089010
A Study of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS) treatment 2 completed NCT05744310
Effects of Long Term Ventilation Support on the Quality of Life of ALS Patients and Their Families No drug interventions treatment Not Available recruiting NCT03843710
31P-MRS Imaging to Assess the Effects of CNM-Au8 on Impaired Neuronal Redox State in Amyotrophic Lateral Sclerosis (REPAIR-ALS) treatment 2 withdrawn NCT05178810
Study to Investigate the Efficacy and Safety of FAB122 (Daily Oral Edaravone) in Patients With Amyotrophic Lateral Sclerosis No drug interventions treatment 3 active_not_recruiting NCT04686110
Analysis of Capillary Retinal and Papillary Vascularization in Patients With Amyotrophic Lateral Sclerosis - CAPISLA No drug interventions other Not Available unknown_status NCT04695210
Virtual Peer-to-peer Support Programme for Carers of MND No drug interventions supportive_care Not Available recruiting NCT01950910
Establishment of a Tissue Bank (Blood, CSF) for the Understanding of Motor Neuron Disease (MND) No drug interventions Not Available Not Available terminated NCT01758510
Safety Study of HLA-haplo Matched Allogenic Bone Marrow Derived Stem Cell Treatment in Amyotrophic Lateral Sclerosis No drug interventions treatment 1 completed NCT02437110
HERV-K Suppression Using Antiretroviral Therapy in Volunteers With Amyotrophic Lateral Sclerosis (ALS) treatment 1 completed NCT04026581
Real World Testing of a Brain-Computer Interface No drug interventions Not Available Not Available completed NCT03693781
Colchicine for Amyotrophic Lateral Sclerosis treatment 2 completed NCT02917681
Study of Two Intrathecal Doses of Autologous Mesenchymal Stem Cells for Amyotrophic Lateral Sclerosis No drug interventions treatment 1 / 2 unknown_status NCT05882695
Study of SPG302 in Healthy Volunteers and ALS Participants treatment 1 recruiting NCT02655614
A Study of GDC-0134 to Determine Initial Safety, Tolerability, and Pharmacokinetic Parameters in Participants With Amyotrophic Lateral Sclerosis treatment 1 completed NCT01984814
Stem Cell Therapy for Amyotrophic Lateral Sclerosis No drug interventions treatment 2 withdrawn NCT04259255
Radicava® (Edaravone) Findings in Biomarkers From ALS (REFINE-ALS) Not Available Not Available active_not_recruiting NCT06215755
A Study of VRG50635 in Participants With Amyotrophic Lateral Sclerosis (ALS) No drug interventions treatment 1 recruiting NCT04952155
Low Dose IL-2 in the Treatment of Immune-associated ALS Syndrome No drug interventions treatment 2 unknown_status NCT04651855
The Evaluation of the Effect of Mesenchymal Stem Cells on the Immune System of Patients With ALS No drug interventions treatment 1 / 2 unknown_status NCT04819555
Frequency of SOD1 and C9orf72 Gene Mutations in French ALS No drug interventions Not Available Not Available completed NCT00919555
Combination Therapy in Amyotrophic Lateral Sclerosis (ALS) treatment 1 / 2 completed NCT05357950
A Phase IIb, Multi-Center, Multinational, Double-Blind, Placebo-Controlled Study, With an Open Label Extension, to Evaluate Safety, Tolerability and Efficacy of PrimeC in Subjects With ALS No drug interventions treatment 2 active_not_recruiting NCT02478450
Study to Investigate the Safety of the Transplantation (by Injection) of Human Glial Restricted Progenitor Cells (hGRPs; Q-Cells®) Into Subjects With Amyotrophic Lateral Sclerosis (ALS) treatment 1 / 2 not_yet_recruiting NCT05959850
A Double-blind Randomised, Placebo-controlled Clinical Trial to Test Ambroxol Treatment in ALS treatment 2 recruiting NCT01259050
Safety Study of High Doses of Zinc in ALS Patients treatment 1 / 2 completed NCT06201650
Neurofilament Light Chain in Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available recruiting NCT04165850
Open Label Study to Evaluate Ciprofloxacin/Celecoxib Combination in Patients With ALS treatment 2 completed NCT05595850
A Mindful Community for People With ALS and Their Primary Caregivers No drug interventions supportive_care Not Available recruiting NCT04961450
Explore Biomarkers of Motor Neuron Disease/Frontal Dementia Spectrum Disease in China No drug interventions Not Available Not Available enrolling_by_invitation NCT00982150
Extension Study of Talampanel for Amyotrophic Lateral Sclerosis (ALS) treatment 2 terminated NCT03367650
Epidemiology and Genetics of the Amyotrophic Lateral Sclerosis in the French West Indies No drug interventions diagnostic Not Available unknown_status NCT04615923
HEALEY ALS Platform Trial - Regimen D Pridopidine treatment 2 / 3 completed NCT00047723
Minocycline to Treat Amyotrophic Lateral Sclerosis treatment 3 completed NCT05035823
COMMAND Early Feasibility Study: Implantable BCI to Control a Digital Device for People With Paralysis No drug interventions device_feasibility Not Available active_not_recruiting NCT00397423
G-CSF Treatment for Amyotrophic Lateral Sclerosis: A RCT Study Assessing Clinical Response treatment 2 completed NCT04840823
Enoxacin for Amyotrophic Lateral Sclerosis (ALS) treatment 1 / 2 completed NCT04952038
Sleep Disorders and the Onset and Progression of ALS No drug interventions Not Available Not Available unknown_status NCT06021938
Alleviating Persistent Dyspnea in Amyotrophic Lateral Sclerosis Patients Treated With Non-Invasive Ventilation Through Immersive Virtual Reality No drug interventions supportive_care Not Available recruiting NCT03359538
Rapamycin Treatment for ALS treatment 2 completed NCT01889043
Monitoring of Non-invasive Ventilation During Sleep in ALS No drug interventions Not Available Not Available completed NCT06147843
French-German Cohort Study to Determine Factors Associated With Weight Loss in Amyotrophic Lateral Sclerosis No drug interventions other Not Available not_yet_recruiting NCT05202743
Online Self-Compassion Course for pALS (Compassion pALS) No drug interventions Not Available Not Available completed NCT01995903
Developing a Discrimination Model to Diagnose ALS No drug interventions diagnostic Not Available completed NCT00718003
Noninvasive Examination of the Work of Breathing in Patients With Amyotrophic Lateral Sclerosis (ALS). No drug interventions Not Available Not Available terminated NCT06266403
Evaluating Verbal Communication in Structured Interactions: Theoretical and Clinical Implications No drug interventions basic_science Not Available not_yet_recruiting NCT01999803
A Safety Study of sNN0029 Administration Via Intracerebroventricular Route to Patients With ALS treatment 1 terminated NCT04719403
Determining Feasibility and Acceptability of Sharing Video Recordings With Patients With ALS and Caregivers No drug interventions health_services_research Not Available completed NCT03268603
Intrathecal Autologous Adipose-derived Mesenchymal Stromal Cells for Amyotrophic Lateral Sclerosis (ALS) treatment 2 active_not_recruiting NCT00125203
Study of Myobloc in the Treatment of Sialorrhea (Drooling) in Patients With Amyotrophic Lateral Sclerosis (ALS) treatment 2 / 3 completed NCT02306590
Efficacy, Safety and Tolerability of High Lipid and Calorie Supplementation in Amyotrophic Lateral Sclerosis No drug interventions treatment Not Available completed NCT03705390
A Safety and Tolerability Study of ILB in Patients With Amyothrophic Lateral Sclerosis (ALS) treatment 2 completed NCT03505021
Effects of Oral Levosimendan (ODM-109) on Respiratory Function in Patients With ALS treatment 3 completed NCT03766321
Fecal Microbiota Transplantation Effect on Amyotrophic Lateral Sclerosis Patients treatment Not Available active_not_recruiting NCT01933321
Effect of Intrathecal Administration of Hematopoietic Stem Cells in Patients With Amyotrophic Lateral Sclerosis (ALS) No drug interventions treatment 2 / 3 completed NCT05695521
Regulatory T Cells for Amyotrophic Lateral Sclerosis No drug interventions treatment 1 recruiting NCT06172621
Spinal Cord Associative Plasticity for ALS No drug interventions other Not Available recruiting NCT02104921
Innovative Ultrasound Technology in Neuromuscular Disease No drug interventions Not Available Not Available completed NCT03876002
Evaluation of Microglial Activation in ALS With [18F]PBR06 (Peripheral Benzodiazepine Receptor-06) PET No drug interventions other 1 completed NCT01772602
The National Amyotrophic Lateral Sclerosis Registry No drug interventions Not Available Not Available recruiting NCT02313402
A New Eye-based Communication Device for ALS Patients No drug interventions Not Available Not Available completed NCT05237284
Phase 2 Study for SAR443820 in Participants With Amyotrophic Lateral Sclerosis (ALS) No drug interventions treatment 2 terminated NCT03764384
Validation Of Tidal/End -Tidal CO2 in ALS No drug interventions Not Available Not Available unknown_status NCT01759784
Intraventricular Transplantation of Mesenchymal Stem Cell in Patients With ALS No drug interventions treatment 1 withdrawn NCT04821479
Repeated Mesenchymal Stem Cell Injections in ALS No drug interventions treatment 1 / 2 completed NCT02460679
Safety and Biomarker Study of EPI-589 in Participants With Amyotrophic Lateral Sclerosis (ALS) treatment 2 completed NCT06280079
Ultra-high-caloric, Fatty Diet in ALS No drug interventions treatment Not Available not_yet_recruiting NCT00560287
Non-Invasive Ventilation in Amyotrophic Lateral Sclerosis No drug interventions supportive_care 4 unknown_status NCT05119387
Genetic Study of Amyotrophic Lateral Sclerosis in Norway No drug interventions Not Available Not Available enrolling_by_invitation NCT03321487
Blood-Brain Barrier Opening Using MR-Guided Focused Ultrasound in Patients With Amyotrophic Lateral Sclerosis No drug interventions treatment Not Available unknown_status NCT06119087
Mechanical Insufflation in the Philadelphia Amyotrophic Lateral Sclerosis Cohort (MI-PALS) Study No drug interventions supportive_care Not Available not_yet_recruiting NCT04051333
The E-health Application To Modify ORal Energy Intake and Measure Outcomes REmotely in ALS Clinical Trial (EAT MORE2) No drug interventions Not Available Not Available completed NCT00801333
Derivation of Induced Pluripotent Stem Cells From an Existing Collection of Human Somatic Cells No drug interventions Not Available Not Available active_not_recruiting NCT02880033
Oxidative Stress and Apoptosis of Energy Metabolism by Deferiprone From the Circulating Lymphocytes basic_science Not Available completed NCT04749433
Study of [11C]CPPC to Assess the Safety and Tolerability in Patients With ALS No drug interventions diagnostic 1 terminated NCT00324454
Levetiracetam for Cramps, Spasticity and Neuroprotection in Motor Neuron Disease treatment 2 completed NCT02383654
Compassionate Treatment : An Exploratory Clinical Trial to Assess Treatment of Amyotrophic Lateral Sclerosis No drug interventions treatment 1 completed NCT04997954
EMERALD TRIAL Open Label Extension Study No drug interventions treatment 4 active_not_recruiting NCT06566651
Emotion Processing Among Patients With ALS No drug interventions Not Available Not Available recruiting NCT00860951
P300 Brain Computer Interface Keyboard to Operate Assistive Technology No drug interventions health_services_research 1 / 2 completed NCT00377351
Confirmation of Self-Reported Incident ALS Cases in the AARP-Diet and Health (AARP-DH) Cohort No drug interventions Not Available Not Available completed NCT05033951
Optimizing INITIation of Non-invasive Ventilation in ALS Patients No drug interventions Not Available Not Available recruiting NCT01825551
The Effect of GCSF in the Treatment of ALS Patients treatment 2 / 3 completed NCT04918251
EEG and TMS-based Biomarkers of ALS, MS and FTD No drug interventions Not Available Not Available unknown_status NCT00812851
Randomized Placebo-Controlled Crossover Trial With THC (Delta 9-Tetrahydrocannabinol) for the Treatment of Cramps in Amyotrophic Lateral Sclerosis (ALS) treatment Not Available completed NCT03508453
IC14 for Treatment of Amyotrophic Lateral Sclerosis No drug interventions treatment 2 withdrawn NCT02942953
Diaphragmatic Pacer Placement: Anesthetic Management (DP) No drug interventions Not Available Not Available completed NCT00847847
Neuromuscular Transmission in Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available completed NCT03900247
Restore Motor Function Through Robotic Arm Exoskeleton and Brain Computer Interface No drug interventions supportive_care Not Available unknown_status NCT04950647
Efficacy and Safety of Nitrazine in the Treatment of ALS treatment 2 unknown_status NCT00925847
Effect of Lithium Carbonate in Patients With Amyotrophic Lateral Sclerosis treatment 2 completed NCT04948645
A Phase 1 Study to Investigate the Safety and Pharmacokinetics of ABBV-CLS-7262 in Patients With Amyotrophic Lateral Sclerosis treatment 1 active_not_recruiting NCT00718445
Pennsylvania Consortium: Clinical Database No drug interventions Not Available Not Available terminated NCT02327845
Phenotype, Genotype & Biomarkers in ALS and Related Disorders No drug interventions Not Available Not Available enrolling_by_invitation NCT04414345
HEALEY ALS Platform Trial - Regimen C CNM-Au8 treatment 2 / 3 completed NCT03868345
Speech Analysis in ALS Patients No drug interventions Not Available Not Available completed NCT06318598
Biomarker-driven Phenotypic Dissection of Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available recruiting NCT00620698
Electrical Impedance Myography as an Outcome Measure in Amyotrophic Lateral Sclerosis Clinical Trials No drug interventions Not Available Not Available completed NCT03160898
A Study to Evaluate Efficacy, Safety and Tolerability of CK-2127107 in Patients With Amyotrophic Lateral Sclerosis (ALS) treatment 2 completed NCT04057898
Evaluation of MN-166 (Ibudilast) for 12 Months Followed by an Open-label Extension for 6 Months in Patients With ALS treatment 2 / 3 recruiting NCT00714805
Non-Invasive Measurement of Gastrointestinal (GI) Motility in Patients With Amyotrophic Lateral Sclerosis (ALS) No drug interventions Not Available Not Available completed NCT06094205
Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Speech-02) No drug interventions other Not Available recruiting NCT03020797
A Clinical Trial to Evaluate the Safety and Efficacy of Fycompa in Subjects With Amyotrophic Lateral Sclerosis (ALS) treatment Not Available terminated NCT03016897
ALS Testing Through Home-based Outcome Measures No drug interventions Not Available Not Available completed NCT00718497
Comparing The Cyberlink Control System to the Manual Letter Board for Communication Purposes in the ALS Patient Population No drug interventions Not Available Not Available completed NCT00298597
Influence of G-CSF and EPO on Associative Learning and Motor Skills treatment 2 completed NCT00965497
Escitalopram (Lexapro) for Depression MS or ALS treatment 3 completed NCT01759797
Intravenous Transplantation of Mesenchymal Stem Cell in Patients With ALS No drug interventions treatment 1 completed NCT01609283
A Dose-escalation Safety Trial for Intrathecal Autologous Mesenchymal Stem Cell Therapy in Amyotrophic Lateral Sclerosis No drug interventions treatment 1 completed NCT04326283
Trial of Safety, Tolerability and Efficacy of Trametinib (SNR1611) in Patients With Amyotrophic Lateral Sclerosis (ALS) treatment 1 / 2 terminated NCT03560661
Acoustic and Perceptual Markers of Dysarthria in Amyotrophic Lateral Sclerosis (ALS) No drug interventions Not Available Not Available completed NCT03840928
PatientSpot Formerly Known as ArthritisPower No drug interventions Not Available Not Available recruiting NCT05742828
Virtual Seating Coach on Power Wheelchairs of Persons With Amyotrophic Lateral Sclerosis (ALS) No drug interventions supportive_care Not Available completed NCT05151211
Use of 1 Minute Sit to Stand Test for Physical Capacity and Effort Related Desaturation in Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available not_yet_recruiting NCT03168711
Safety of Urate Elevation in Amyotrophic Lateral Sclerosis (ALS) treatment 2 completed NCT04691011
New Magnetic Resonance Imaging Biomarkers in Amyotrophic Lateral Sclerosis No drug interventions diagnostic Not Available recruiting NCT00879593
Nocturnal PtcCO2 Monitoring in Patients With Amyotrophic Lateral Sclerosis (ALS) No drug interventions prevention Not Available completed NCT00580593
Trial of Early Noninvasive Ventilation for Amyotrophic Lateral Sclerosis (ALS) No drug interventions treatment 1 completed NCT00070993
Creatine for the Treatment of Amyotrophic Lateral Sclerosis No drug interventions treatment 2 completed NCT03986671
Transmembrane Electromyography (TM-EMG) for the Assessment of Neuromuscular Function in the Oropharynx No drug interventions diagnostic Not Available completed NCT03613571
A Study to Evaluate the Safety, Tolerability and Efficacy of ILB in Patients With Amyotrophic Lateral Sclerosis No drug interventions treatment 2 terminated NCT05095571
A Trial of Nicotinamide/Pterostilbene Supplement in ALS: The NO-ALS Extension Study No drug interventions treatment Not Available recruiting NCT05470478
iBCI Optimization for Veterans With Paralysis No drug interventions other Not Available not_yet_recruiting NCT02852278
A Patient Centric Motor Neuron Disease Activities of Daily Living Scale No drug interventions Not Available Not Available completed NCT05423678
Clinical Trial - Analyzing Participation Experiences Of Amyotrophic Lateral Sclerosis Patients No drug interventions Not Available Not Available not_yet_recruiting NCT01583088
Early Stage Amyotrophic Lateral Sclerosis Phrenic Stimulation No drug interventions treatment 3 terminated NCT00956488
Supported Treadmill Ambulation Training (STAT) for Patients Diagnosed With Amyotrophic Lateral Aclerosis No drug interventions prevention 1 / 2 completed NCT03835507
Randomized, Double-blind, Safety and Efficacy of Recombinant Human Erythropoietin in Amyotrophic Lateral Sclerosis other 1 / 2 recruiting NCT02588807
Food Supplement for the Treatment of Patients With Amyotrophic Lateral Sclerosis No drug interventions treatment 1 withdrawn NCT02306109
Effect of Motor Rehabilitation Treatment on Amyotrophic Lateral Sclerosis (ALS) No drug interventions treatment Not Available completed NCT00072709
Study Evaluating TCH346 and Placebo Administered Once Daily in Patients With Amyotrophic Lateral Sclerosis (ALS) treatment 2 completed NCT04245709
Clenbuterol on Motor Function in Individuals With Amyotrophic Lateral Sclerosis treatment 2 completed NCT03136809
ALS Treatment Extension Study treatment 1 / 2 unknown_status NCT04288856
Study to Assess the Safety, Tolerability, Pharmacokinetics, and Effect on Disease Progression of BIIB078 Administered to Previously Treated Adults C9ORF72-Associated Amyotrophic Lateral Sclerosis (ALS) No drug interventions treatment 1 terminated NCT05136885
HEALEY ALS Platform Trial - Regimen E SLS-005 - Trehalose No drug interventions treatment 2 / 3 completed NCT00035815
Insulin-like Growth Factor-1 in Amyotrophic Lateral Sclerosis (ALS) Trial No drug interventions treatment 3 completed NCT05747937
Longitudinal Assessment of Autonomic and Sensory Nervous System in ALS No drug interventions basic_science Not Available recruiting NCT00563537
Molecular Imaging Modality by Positron Emission Tomography Using 18F-X : Study of Microglial Activation in Amyotrophic Lateral Sclerosis No drug interventions diagnostic 1 unknown_status NCT06491732
EIM Via the Myolex mScan as an ALS Biomarker No drug interventions Not Available Not Available not_yet_recruiting NCT03076632
Interactions Between Neurostimulation and Physical Exercise No drug interventions device_feasibility Not Available withdrawn NCT03090932
Longitudinal Study of Innate Lymphoid Cells in Peripheral Blood in ALS No drug interventions Not Available Not Available terminated NCT02058732
Therapeutic Imaging Biomarkers for Amyotrophic Lateral Sclerosis No drug interventions other Not Available terminated NCT02450552
Clinical Trial of Ezogabine (Retigabine) in ALS Subjects treatment 2 completed NCT05753852
Open Label Extension of TUDCA-ALS Study treatment 3 recruiting NCT02447952
Exploratory Study of Biotelemetry in Amyotrophic Lateral Sclerosis No drug interventions other Not Available completed NCT05006352
A Study to Determine the Safety, Pharmacokinetics, and Pharmacodynamics of DNL343 in Participants With Amyotrophic Lateral Sclerosis treatment 1 active_not_recruiting NCT01123200
An In-home Study of Brain Computer Interfaces No drug interventions supportive_care Not Available completed NCT03489200
EH301 for the Treatment of ALS No drug interventions treatment Not Available completed NCT03204500
Dual Treatment With Lithium and Valproate in ALS. No drug interventions treatment 2 completed NCT05633459
A Study Evaluating the Safety and Tolerability of QRL-201 in ALS No drug interventions treatment 1 recruiting NCT02059759
Immuno-modulation in Amyotrophic Lateral Sclerosis- a Phase II Study of Safety and Activity of Low Dose Interleukin-2 treatment 2 completed NCT06219759
Reinnervation and Neuromuscular Transmission in ALS No drug interventions Not Available Not Available recruiting NCT05725759
Rehabilitation in SOD1 ALS Treated With Tofersen No drug interventions Not Available Not Available enrolling_by_invitation NCT03679975
Riluzole Oral Soluble Film (ROSF) Swallowing Safety in Amyotrophic Lateral Sclerosis (ALS) other 2 terminated NCT03683875
Ultrasonography of the Neuromuscular Degeneration Behavior in Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available completed NCT04428775
A Safety and Biomarker Study of ALZT-OP1a in Subjects With Mild-Moderate ALS Disease basic_science 2 terminated NCT00023075
Nuclear Magnetic Spectroscopy Imaging to Evaluate Primary Lateral Sclerosis, Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available completed NCT00107770
Safety Study of Oral Sodium Phenylbutyrate in Subjects With ALS (Amyotrophic Lateral Sclerosis) treatment 1 / 2 completed NCT04455542
Peripheral Neurofilament Levels and Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available completed NCT02872142
Efficacy and Safety of Plasma Exchange With Albutein® 5% in Participants With Amyotrophic Lateral Sclerosis treatment 2 completed NCT01091142
Single-Ascending-Dose Safety/Tolerability of NP001 in Amyotrophic Lateral Sclerosis (ALS) No drug interventions treatment 1 completed NCT05039099
A Study to Evaluate, Safety, Tolerability, Pharmacodynamic (PD) Markers and Pharmacokinetics (PK) of AP-101 in Participants With Amyotrophic Lateral Sclerosis (ALS) treatment 2 active_not_recruiting NCT06046599
Remote Home Assessment of Patients With Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available recruiting NCT04745299
Evaluation the Efficacy and Safety of Mutiple Lenzumestrocel (Neuronata-R® Inj.) Treatment in Patients With ALS treatment 3 active_not_recruiting NCT02374606
Accurate Test of Limb Isometric Strength (ATLIS) in ALS No drug interventions Not Available Not Available unknown_status NCT06203106
NYSCF Scientific Discovery Biobank No drug interventions Not Available Not Available recruiting NCT03664206
Assessing Motor Neuron Disease Mechanisms by Threshold Tracking Transcranial Magnetic Stimulation and Magnetic Resonance Spectroscopy No drug interventions Not Available Not Available withdrawn NCT04875949
Anti-Cholinergic Receptors Antibodies, Autonomic Profile and Dysautonomia Symptoms in PAF, ALS and POTS (DISAUT-AB) No drug interventions supportive_care Not Available completed NCT03651349
To Determine the Maximum Tolerated Dose (MTD) of HK-001 in Healthy Volunteers No drug interventions treatment 1 active_not_recruiting NCT01709149
Study of Safety, Tolerability & Efficacy of CK-2017357 in Amyotrophic Lateral Sclerosis (ALS) treatment 2 completed NCT05107349
Cell Signaling, Reinnervation and Metabolism in Kennedy Disease and Amyotrophic Lateral Sclerosis (ALS) No drug interventions other Not Available recruiting NCT01486849
Dose Titration Study to Test Safety and Effects of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS) treatment 2 completed NCT02269436
A follow-on Study to Assess Long-term Safety and Tolerability of i.c.v Administration of sNN0029 in Patients With ALS treatment 1 terminated NCT05021536
Phase III Trial of AMX0035 for Amyotrophic Lateral Sclerosis Treatment No drug interventions treatment 3 active_not_recruiting NCT04140136
The Efficacy and Safety of Vitamin E Mixed Tocotrienols In Patients With Amyotrophic Lateral Sclerosis (ALS) No drug interventions treatment 2 unknown_status NCT03981536
A Study to Evaluate AP-101 in Familial and Sporadic Amyotrophic Lateral Sclerosis (ALS) basic_science 1 unknown_status NCT00714636
Cerebrospinal Fluid Repository No drug interventions Not Available Not Available completed NCT02567136
Imaging Biomarkers in ALS No drug interventions Not Available Not Available active_not_recruiting NCT05597436
Intermediate-Sized Expanded Access Study Not Available Not Available no_longer_available NCT05740813
HEALEY ALS Platform Trial - Regimen F ABBV-CLS-7262 treatment 2 / 3 enrolling_by_invitation NCT02507713
Quantitative Neuromuscular Ultrasonography in Amyotrophic Lateral Sclerosis (ALS) No drug interventions Not Available Not Available completed NCT01650818
Aerobic Exercise Training in Amyotrophic Lateral Sclerosis No drug interventions supportive_care Not Available unknown_status NCT03452618
Predictive Factors for the Diagnosis of Early Noninvasive Ventilation Equipment No drug interventions diagnostic Not Available unknown_status NCT01897818
Communication by Brain - Computer Interface in Amyotrophic Lateral Sclerosis:Feasibility Study No drug interventions supportive_care Not Available unknown_status NCT04681118
Expanded Access Protocol: Repeated Administration of Nurown® (Autologous MSC-NTF Cells) for the Treatment of ALS Not Available Not Available no_longer_available NCT01935518
A Clinical Trial of Safety and Efficacy of Fasudil in Subjects With Amyotrophic Lateral Sclerosis (ALS) treatment 2 unknown_status NCT05852418
Registry Study of Assistive Devices, Medicines and Healthcare Measures in ALS, SMA and Other Neurological Diseases. No drug interventions Not Available Not Available recruiting NCT04939818
Clinical Feasibility of Speech Phenotyping for Remote Assessment of Neurodegenerative and Psychiatric Disorders No drug interventions Not Available Not Available completed NCT01879241
Study of Rasagiline in Patients With Amyotrophic Lateral Sclerosis treatment 2 completed NCT05842941
HEALEY ALS Platform Trial - Regimen G DNL343 treatment 2 / 3 enrolling_by_invitation NCT03202017
Lung Volume Recruitment Combined With Expiratory Muscle Strength Training in ALS No drug interventions supportive_care Not Available completed NCT05204017
Comprehensive Analysis Platform To Understand, Remedy and Eliminate ALS No drug interventions Not Available Not Available recruiting NCT03806634
Development and Needs Assessment and Efficiency of Smart Communication System for Patients With ALS (Part 2) No drug interventions Not Available Not Available unknown_status NCT02870634
Phase 1 Dose Escalation and PK Study of Cu(II)ATSM in ALS/MND treatment 1 completed NCT06069934
Pridopidine in Amyotrophic Lateral Sclerosis (EAP 2) Not Available Not Available available NCT05764434
ALS Spinal Cord Gray and White Matter Study No drug interventions Not Available Not Available recruiting NCT02116634
Mesenchymal Stem Cell Injection in Amyotrophic Lateral Sclerosis No drug interventions treatment 1 / 2 withdrawn NCT00809224
Cortex Changes in Real/Imagined Movements in Amyotrophic Lateral Sclerosis (ALS) No drug interventions Not Available Not Available completed NCT05928416
ALS Diagnosis From a Saliva Sample: a Non-coding RNA Analysis Approach No drug interventions Not Available Not Available recruiting NCT00317616
The Pre-symptomatic Familial Amyotrophic Lateral Sclerosis (Pre-fALS) Study No drug interventions Not Available Not Available recruiting NCT00718016
Assessment of the Cyberlink Control System for Use by the Amyotrophic Lateral Sclerosis (ALS) Patient No drug interventions Not Available Not Available terminated NCT03217396
Biomarkers of Synaptic Damage in Multiple Sclerosis No drug interventions Not Available Not Available recruiting NCT01925196
Natural History and Biomarkers of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Caused by the C9ORF72 Gene Mutation No drug interventions Not Available Not Available completed NCT06169696
EMPOWER Early Feasibility Study: Non-invasive BCI to Control a Wheelchair for People With Paralysis No drug interventions device_feasibility Not Available not_yet_recruiting NCT05299658
An Open-Label Extension for the Phase 2 Study in Early Symptomatic Amyotrophic Lateral Sclerosis Patients on Stable Background Therapy to Assess Bioenergetic Catalysis With CNM-Au8 to Slow Disease Progression in ALS No drug interventions treatment 2 active_not_recruiting NCT01906658
A Study to Explore the Safety and Tolerability of Acthar in Patients With Amyotrophic Lateral Sclerosis treatment 2 completed NCT00116558
Early Treatment of Amyotrophic Lateral Sclerosis (ALS) With Nutrition and Non-Invasive Positive Pressure Ventilation No drug interventions supportive_care Not Available completed NCT00718458
EEG-Based Brain-Computer Interface Project for Individuals With Amyotrophic Lateral Sclerosis (ALS) No drug interventions Not Available Not Available completed NCT01569958
Transcranial Direct Current Stimulation as a Novel Therapeutic Approach in Amyotrophic Lateral Sclerosis No drug interventions treatment 2 unknown_status NCT03362658
Novel MRI Biomarkers for Monitoring Disease Progression in ALS No drug interventions Not Available Not Available recruiting NCT06429735
Precise Robotically IMplanted Brain-Computer InterfacE No drug interventions device_feasibility Not Available recruiting NCT05053035
A Phase 2 Study to Evaluate AL001 in C9orf72-Associated ALS treatment 2 terminated NCT03487263
Dose-Escalation, Safety and Pharmacokinetic Study of IC14 in Motor Neurone Disease No drug interventions treatment 1 completed NCT01160263
Study of Dopamine and Serotonin Transporters in Patients With Amyotrophic Lateral Sclerosis and Controls diagnostic 3 completed NCT02548663
Sport Therapy and Osteopathy Manipulative Treatment in ALS No drug interventions treatment Not Available completed NCT05880563
Investigation of Cannabinoid 2-receptor Expression in the Brain and Spine of ALS-patients Compared to Healthy Controls With PET (18F-RoSMALS) No drug interventions basic_science 1 not_yet_recruiting NCT02665663
Tongue Strength in Amyotrophic Lateral Sclerosis (ALS) No drug interventions screening Not Available unknown_status NCT02290886
A Multicenter Phase I/II Clinical Trial to Evaluate Safety of Mesenchymal Stem Cell in Patients With Amyotrophic Sclerosis Lateral No drug interventions treatment 1 / 2 completed NCT01254539
Clinical Trial on The Use of Autologous Bone Marrow Stem Cells in Amyotrophic Lateral Sclerosis (Extension CMN/ELA) No drug interventions treatment 1 / 2 completed NCT04305639
The Reliability and Validity of Turkish Version of ''The Dyspnea-ALS-Scale (DALS-15)" No drug interventions Not Available Not Available completed NCT02315339
European Home Mechanical Ventilation Registry No drug interventions Not Available Not Available terminated NCT03326622
Exercise and Disease Progression in Amyotrophic Lateral Sclerosis Patients No drug interventions supportive_care Not Available completed NCT04240925
Tolerability, Safety and Efficacy of Sigh Breaths During NIMV in Motor Neuron Disease No drug interventions supportive_care Not Available unknown_status NCT04632225
Safety of Engensis in Participants With Amyotrophic Lateral Sclerosis treatment 2 completed NCT06426030
Validation of Czech Language Versions of Questionnaires for ALS Patients' Functional Status and Biomarker Long-term Follow-up No drug interventions Not Available Not Available recruiting NCT05829330
Ambulatory Versus Inpatient Initiation of Home Mechanical Ventilation No drug interventions treatment Not Available recruiting NCT03113630
Virtual Task in Amyotrophic Lateral Sclerosis No drug interventions treatment Not Available completed NCT02682030
The Use of Airway Clearance Devices in ALS No drug interventions treatment Not Available completed NCT02869048
Amyotrophic Lateral Sclerosis and the Innate Immune System No drug interventions Not Available Not Available recruiting NCT03481348
Pharyngeal Electrical Stimulation in Amyotrophic Lateral Sclerosis No drug interventions treatment 1 / 2 completed NCT00958048
Effects of Nocturnal Non-invasive Ventilation in Patients With Amyotrophic Lateral Sclerosis No drug interventions treatment Not Available completed NCT03067857
Autologous Bone Marrow-Derived Stem Cell Therapy for Motor Neuron Disease No drug interventions treatment 1 / 2 unknown_status NCT00004457
Determinants of Disease Severity in Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available unknown_status NCT02238626
Ibudilast (MN-166) in Subjects With Amyotrophic Lateral Sclerosis (ALS) treatment 2 completed NCT06392126
Personalized Antisense Oligonucleotide Therapy for A Single Participant With CHCHD10 ALS No drug interventions treatment 1 / 2 active_not_recruiting NCT05866926
Study to Investigate the Long-term Safety of FAB122 in Patients With Amyotrophic Lateral Sclerosis No drug interventions treatment 3 terminated NCT02670226
Muscular Biomarkers in Amyotrophic Lateral Sclerosis No drug interventions health_services_research Not Available completed NCT01378026
Study of the Role of G72 in Amyotrophic Lateral Sclerosis: Biomarker Discovery and Mechanism Investigation No drug interventions Not Available Not Available unknown_status NCT03618966
Neuromuscular Magnetic Stimulation in ALS Patients No drug interventions treatment 2 completed NCT00005766
Clinical Trial of Creatine in Amyotrophic Lateral Sclerosis treatment 2 completed NCT04579666
MERIDIAN: A Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults With Amyotrophic Lateral Sclerosis (ALS) treatment 2 terminated NCT00353665
Memantine for Disability in Amyotrophic Lateral Sclerosis (MEDALS) treatment 2 / 3 completed NCT06325865
Perception of Unpleasant Sensations During Study Procedures in ALS Patients No drug interventions Not Available Not Available recruiting NCT04248465
An Efficacy and Safety Study of Ravulizumab in ALS Participants treatment 3 terminated NCT02236065
Combination Therapy of Cord Blood and G-CSF for Patients With Brain Injury or Neurodegenerative Disorders treatment Not Available completed NCT00230074
A Long-term Extension Study of TCH346 and Placebo Administered Once Daily in Patients With Amyotrophic Lateral Sclerosis(ALS) treatment 2 completed NCT00005674
Clinical Trial of Creatine in Amyotrophic Lateral Sclerosis [ALS] treatment 2 completed NCT01090674
Relationship Between Respiratory Functional Tests and Image Thoracic Techniques in Patients With Neuromuscular Diseases No drug interventions Not Available Not Available completed NCT02611674
Methodology Study of Novel Outcome Measures to Assess Progression of ALS No drug interventions Not Available Not Available completed NCT00833820
Repetitive Transcranial Magnetic Stimulation (rTMS) in Amyotrophic Lateral Sclerosis No drug interventions treatment 2 / 3 completed NCT00714220
Quantitative Measurement of Nutritional Substrate Utilization in Patients With Amyotrophic Lateral Sclerosis (ALS) No drug interventions Not Available Not Available terminated NCT03456882
The Effect of RNS60 on ALS Biomarkers No drug interventions other 2 completed NCT02405182
MRI Biomarkers in ALS No drug interventions Not Available Not Available completed NCT02750982
Laughter Therapy Effects on Mood, Stress and Self-efficacy in People With Neurological Diseases. No drug interventions health_services_research Not Available completed NCT05358431
Stratification of Presymptomatic Amyotrophic Lateral Sclerosis: the Development of Novel Imaging Biomarkers No drug interventions other Not Available recruiting NCT01281631
A Study of NP001 in Subjects With Amyotrophic Lateral Sclerosis (ALS) No drug interventions treatment 2 completed NCT01020331
Memantine Therapy in Amyotrophic Lateral Sclerosis treatment 2 completed NCT05819931
Breathing With Amyotrophic Lateral Sclerosis No drug interventions treatment Not Available recruiting NCT04562831
The NO-ALS Study: A Trial of Nicotinamide/Pterostilbene Supplement in ALS. No drug interventions treatment Not Available recruiting NCT00716131
Amyotrophic Lateral Sclerosis (ALS) Tissue Donation Program No drug interventions Not Available Not Available completed NCT06541873
Gait Patterns in Dual-task Conditions in Patients With Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available not_yet_recruiting NCT05724173
Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia No drug interventions other Not Available recruiting NCT04816227
Expression Profile Study of Macrophages From Patients Affected by ALS or Other Related Motor Impairments No drug interventions Not Available Not Available recruiting NCT06100276
Safety, Tolerability, and Exploratory Efficacy Study of Intrathecally Administered Gene Therapy AMT-162 in Adult Participants With SOD1 Amyotrophic Lateral Sclerosis (SOD1-ALS) treatment 1 / 2 recruiting NCT00355576
Combination Therapy Selection Trial in Amyotrophic Lateral Sclerosis treatment 2 completed NCT05542576
AMDX-2011P Retinal Tracer in Subjects With Neurodegenerative Diseases Associated With Amyloidogenic Proteinopathy No drug interventions diagnostic 1 / 2 recruiting NCT00339976
Exposure to Neurotoxins as Risk Factors for Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available completed NCT01424176
Dexpramipexole Renal PK Study basic_science 1 completed NCT02881476
Therapeutic Treatment of Amyotrophic Lateral Sclerosis No drug interventions treatment 1 unknown_status NCT01753076
Study of Ozanezumab (GSK1223249) Versus Placebo in the Treatment of Amyotrophic Lateral Sclerosis treatment 2 completed NCT04257760
Evaluation of Palliative Care for Patients With ALS and Their Caregivers No drug interventions treatment Not Available completed NCT06396260
Structural and Functional Networks in ALS: An Insight Into Pseudobulbar Affect No drug interventions other Not Available not_yet_recruiting NCT00635960
Growth Hormone in Amyotrophic Lateral Sclerosis treatment 2 completed NCT05562960
Plasmapheresis in Amyotrophic Lateral Sclerosis With Autoantibody Against NRIP No drug interventions treatment Not Available recruiting NCT03516994
Reducing Disparities in the Quality of Advance Care Planning for Older Adults No drug interventions other Not Available completed NCT01854294
GM604 Phase 2A Randomized Double-blind Placebo Controlled Pilot Trial in Amyotrophic Lateral Disease (ALS) treatment 2 completed NCT06556394
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RAG-17 in Subjects With Amyotrophic Lateral Sclerosis (ALS) With Superoxide Dismutase Type 1 (SOD1) Gene Mutation treatment 1 not_yet_recruiting NCT06450691
Modeling Amyotrophic Lateral Sclerosis With Fibroblasts No drug interventions other Not Available not_yet_recruiting NCT03706391
Study of ALS Reversals 4: LifeTime Exposures No drug interventions Not Available Not Available completed NCT03491462
Arimoclomol in Amyotropic Lateral Sclerosis treatment 3 completed NCT02710162
Accurate Screening Tools for Dysphagia in Amyotrophic Lateral Sclerosis (ALS) diagnostic 0 completed NCT03519880
A Pilot Study of the Utility of 3D Printed Masks for ALS Subjects No drug interventions device_feasibility Not Available terminated NCT01511029
Study to Evaluate the QTC Interval in Healthy Volunteers Dosed With Dexpramipexole (QTC = Electrocardiogram (ECG) Interval Measured From the Onset of the QRS Complex to the End of the T Wave Corrected for Heart Rate) treatment 1 completed NCT04008329
A Registered Cohort Study on Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available recruiting NCT06206629
Contralateral R1 in Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available recruiting NCT00818389
Study to Investigate the Safety and Efficacy of Lithium in Volunteers With Amyotrophic Lateral Sclerosis (ALS) treatment 2 / 3 terminated NCT03095989
An Online Mindfulness Intervention for People With ALS and Their Caregivers No drug interventions supportive_care Not Available completed NCT04172792
Safety and Tolerability Ultra-high-caloric Food Supplements in Amyotrophic Lateral Sclerosis (ALS) No drug interventions treatment 1 completed NCT03382392
Hypermetabolism in ALS Using Six REE Formulas No drug interventions Not Available Not Available completed NCT02532244
Genetics of Pediatric-Onset Motor Neuron and Neuromuscular Diseases No drug interventions Not Available Not Available recruiting NCT02166944
Tamoxifen Treatment in Patients With Motor Neuron Disease treatment 1 / 2 completed NCT00673140
Far Infrared Irradiation for Control, Management and Treatment of Amyotrophic Lateral Sclerosis (ALS) No drug interventions treatment 1 unknown_status NCT03186040
Open-label Clinical Trial of Lacosamide in ALS treatment 1 / 2 completed NCT01771640
Intrathecal Transplantation of Mesenchymal Stem Cell in Patients With ALS No drug interventions treatment 1 completed NCT04960540
Multimodal Brain Imaging Study No drug interventions Not Available Not Available unknown_status NCT01551940
Toxin Treatment for Amyotrophic Lateral Sclerosis (ALS) Related Sialorrhea treatment 2 completed NCT04454840
Treatment of Intravenous Infusion Plasma in Amyotrophic Lateral Sclerosis treatment 0 completed NCT04518540
Explore Neuroprotective Effect of Lipoic Acid in Amyotrophic Lateral Sclerosis treatment Not Available unknown_status NCT01640067
Human Neural Stem Cell Transplantation in Amyotrophic Lateral Sclerosis (ALS) No drug interventions Not Available 1 completed NCT06249867
A Study to Assess the Safety, Tolerability, and Pharmacology of Darifenacin in Patients With ALS treatment 2 not_yet_recruiting NCT05404867
Study of Structural and Functional Brain Connectivity Changes in ALS (CoALS-II) No drug interventions other Not Available completed NCT02496767
Ventilatory Investigation of Tirasemtiv and Assessment of Longitudinal Indices After Treatment for a Year treatment 3 completed NCT05003167
Effectiveness of Expiratory Muscle Strength Training for Improving Communication in ALS No drug interventions treatment Not Available completed NCT00748501
Clinical Trial of SB-509 in Subjects With Amyotrophic Lateral Sclerosis (ALS) treatment 2 completed NCT03296501
Intraspinal Transplantation of Autologous ADRC in ALS Patients No drug interventions treatment 1 unknown_status NCT03811301
[BrainConnexion] - Neurodevice Phase I Trial No drug interventions other Not Available active_not_recruiting NCT06307301
Study in ALS With Abatacept & IL-2 treatment 1 active_not_recruiting NCT06228001
Holter of Movement in Patients With Amyotrophic Lateral Sclerosis. No drug interventions Not Available Not Available recruiting NCT02039401
Safety Study of VM202 to Treat Amyotrophic Lateral Sclerosis treatment 1 / 2 completed NCT00800501
A Safety and Tolerability Study of Intracerebroventricular Administration of sNN0029 to Patients With Amyotrophic Lateral Sclerosis treatment 1 / 2 completed NCT01363401
Safety and Efficacy Study of Autologous Bone Marrow Derived Stem Cell Treatment in Amyotrophic Lateral Sclerosis No drug interventions treatment 1 / 2 completed NCT01119001
A P300 Brain Computer Interface Keyboard to Control Assistive Technology For Use by People With Amyotrophic Lateral Sclerosis No drug interventions supportive_care Not Available completed NCT04309604
IC14 for ALS Patients Expanded Access No drug interventions Not Available Not Available no_longer_available NCT00160004
The Effect of Intensive Controlled Exercise in the Early Stages of Amyotrophic Lateral Sclerosis No drug interventions treatment 1 / 2 terminated NCT03285204
Relationship Between Neurological Disability and Visual Impairment in Patients With ALS or Friedreich's Ataxia No drug interventions Not Available Not Available unknown_status NCT02011204
Study of Electrical Impedance Myography (EIM) in ALS No drug interventions Not Available Not Available completed NCT05039268
3K3A-APC for Treatment of Amyotrophic Lateral Sclerosis (ALS) No drug interventions treatment 2 completed NCT05218668
Rho Kinase Inhibitor in Amyotrophic Lateral Sclerosis (REAL) treatment 2 recruiting NCT03377868
Optic Coherence Tomography in Patients With Amyotrophic Lateral Sclerosis No drug interventions diagnostic Not Available unknown_status NCT03793868
Perampanel Single Ascending Dose Transcranial Magnetic Stimulation Biomarker Study in Amyotrophic Lateral Sclerosis other 0 completed NCT03293069
Conservative Iron Chelation as a Disease-modifying Strategy in Amyotrophic Lateral Sclerosis treatment 2 / 3 active_not_recruiting NCT01777646
Autologous Mesenchymal Bone Marrow Stromal Cells Secreting Neurotrophic Factors (MSC-NTF), in Patients With Amyotrophic Lateral Sclerosis (ALS) No drug interventions treatment 2 completed NCT00537446
Effect of Noninvasive Ventilation on Lung Function in Amyotrophic Lateral Sclerosis No drug interventions supportive_care Not Available terminated NCT05768646
Counterfactual Thinking in Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available recruiting NCT03214146
Safety/Efficacy Study of 2nd Cycle Treatment After 6 Months of 1st Cycle HLA-haplo Matched Allogenic Bone Marrow Derived Stem Cell Treatment in ALS No drug interventions treatment 1 unknown_status NCT02418546
Electronic-health Application To Measure Outcomes REmotely Clinical Trial No drug interventions supportive_care Not Available completed NCT00542412
CARE Canadian ALS Riluzole Evaluation treatment 4 completed NCT00331812
Mitochondrial Functions and Oxidative Stress in ALS Patients No drug interventions Not Available Not Available unknown_status NCT00136110
Trial of Sodium Valproate in Amyotrophic Lateral Sclerosis treatment 3 completed NCT02710110
Respiratory Strength Training in Persons With Amyotrophic Lateral Sclerosis (ALS) treatment 0 completed NCT04436510
HEALEY ALS Platform Trial - Regimen B Verdiperstat treatment 2 / 3 completed NCT04557410
Open Label Study: Treatment of ALS Fatigue With PolyMVA No drug interventions supportive_care 1 completed NCT05104710
Intermuscular Coherence as a Biomarker for ALS No drug interventions Not Available Not Available recruiting NCT04953481
Home Care Needs and Current Nursing Status of Patients With Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available unknown_status NCT03883581
Impact of Nuedexta on Bulbar Physiology and Function in ALS treatment 1 / 2 completed NCT01257581
Safety and Efficacy Study of Creatine and Tamoxifen in Volunteers With Amyotrophic Lateral Sclerosis (ALS) treatment 2 completed NCT06578195
ASSESS ALL ALS Study No drug interventions Not Available Not Available recruiting NCT01565395
Incobotulinum Toxin A for Sialorrhea in Parkinson's Disease (PD)/Parkinsonism and Amyotrophic Lateral Sclerosis (ALS) treatment 2 withdrawn NCT05830214
Digital Smartwatch Measurements as Potential Biomarkers for Remote Disease Tracking in ALS No drug interventions Not Available Not Available withdrawn NCT03338114
Study to Evaluate the Safety & Efficacy of FLX-787-ODT to Treat Fasciculations in Tongue and Upper or Lower Extremity Muscles Most Affected in Subjects With ALS No drug interventions treatment 1 / 2 withdrawn NCT03127514
AMX0035 in Patients With Amyotrophic Lateral Sclerosis (ALS) treatment 2 completed NCT02851914
SSRIs vs. TCAs for Depression in ALS Patients treatment 0 completed NCT05041114
SWITCH II Early Feasibility Study: Implantable BCI to Control a Digital Device for People With Paralysis No drug interventions treatment Not Available withdrawn NCT05019014
Olfactory Deficits in Neurologic Disease No drug interventions Not Available Not Available completed NCT04858555
Staging System in Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available recruiting NCT05279755
A Study to Evaluate the Safety and Pharmacokinetics of Single and Multiple Doses of Prosetin in Healthy Volunteers treatment 1 unknown_status NCT04993755
A Phase 2a Study of TPN-101 in Patients With C9ORF72 ALS/FTD No drug interventions treatment 2 active_not_recruiting NCT02943850
CNS10-NPC-GDNF for the Treatment of ALS No drug interventions treatment 1 completed NCT02962050
Delineating Swallowing Impairment and Decline in ALS Not Available Not Available completed NCT06315608
MRG-001 in Patients With Amyotrophic Lateral Sclerosis No drug interventions treatment 2 not_yet_recruiting NCT01874808
From Movement Preparation to Gait Execution in ALS No drug interventions Not Available Not Available completed NCT03975608
Psychological Therapy for Patients With ALS No drug interventions supportive_care Not Available completed NCT03984708
New Therapeutic Strategy in ALS Based on Metabolic Status and Associated Metabolic Pathways. No drug interventions health_services_research Not Available active_not_recruiting NCT05309408
A Longitudinal Analysis of Biomarkers in Patients With ALS No drug interventions Not Available Not Available recruiting NCT03613038
A Systematic Investigation of Phonetic Complexity Effects on Articulatory Motor Performance in Progressive Dysarthria No drug interventions basic_science Not Available completed NCT03887338
Systematic Laryngoscopic Evaluation of Upper Airways in Ventilated ALS Patients in Portugal and in Norway No drug interventions supportive_care Not Available unknown_status NCT01530438
Study of Cognitive and Emotional Disorders in Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available unknown_status NCT05116943
Biospecimen Biorepository for the Study of ALS, ALS-FTD and Similar Neurodegenerative Disorders No drug interventions Not Available Not Available recruiting NCT04390386
Controlled Study of IC14 for Treatment of ALS No drug interventions treatment 2 withdrawn NCT04446325
Venous Disease Thromboembolic and Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available completed NCT04569084
Efficacy and Safety Study of Oral Edaravone Administered in Subjects With ALS treatment 3 terminated NCT06377033
Using the EHR to Advance Genomic Medicine Across a Diverse Health System No drug interventions health_services_research Not Available recruiting NCT03457753
Riluzole Oral Soluble Film Safety and Tolerability in Amyotrophic Lateral Sclerosis other 2 withdrawn NCT01583205
Coping Effectiveness Training for ALS No drug interventions treatment Not Available withdrawn NCT02795897
Genomic Translation for Amyotrophic Lateral Sclerosis Care No drug interventions Not Available Not Available completed NCT04224961
Respiratory Muscle Training (RMT) in ALS No drug interventions supportive_care Not Available completed NCT05581771
Factors Associated With Success of NIPPV in ALS Patients No drug interventions Not Available Not Available completed NCT05151471
Efficacy and Safety Extension Study of Oral Edaravone Administered in Subjects With ALS treatment 3 terminated NCT02228915
Analysis of Post-Translational Modifications of a Critical Protein Implicated in Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available completed NCT05568615
Extension Study Following the Studies MT-1186-A03 or A04 to Evaluate the Safety of Oral Edaravone in Subjects With ALS treatment 3 completed NCT05602142
Study of [11C]CPPC as a Clinical PET Radioligand Biomarker of Microglial Activation in ALS No drug interventions diagnostic 1 / 2 not_yet_recruiting NCT03366506
Investigation of the Epidemiological Factors Associated With the Development of Amyotrophic Lateral Sclerosis (ALS) No drug interventions Not Available Not Available recruiting NCT06005506
National Multicenter Interventional Study Aimed at Evaluating the Effect on the Intestinal Microbiota in Chronically Frail Patients Who Share Alterations in Intestinal Function. No drug interventions supportive_care Not Available completed NCT05621213
Satisfaction of Patients With Amyotrophic Lateral Sclerosis Regarding Home Assisted Teleconsultation No drug interventions health_services_research Not Available recruiting NCT04054141
rTMS in Treatment of Spasticity No drug interventions treatment Not Available terminated NCT06286917
Initiation of Noninvasive Ventilation in ALS Patients With Chronic Respiratory Insufficiency No drug interventions basic_science Not Available recruiting NCT06511934
Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Tablet-01) No drug interventions device_feasibility Not Available recruiting NCT03214224
Remote Pulmonary Function Testing in Amyotrophic Lateral Sclerosis (Pilot) No drug interventions health_services_research Not Available completed NCT04165824
Safety Study of Oral Edaravone Administered in Subjects With ALS treatment 3 completed NCT04490096
Multimodal Imaging Outcome Measures for ALS (Image ALS) No drug interventions diagnostic 1 terminated NCT05287958
Feasibility of an Electrical Impedance Tomography Device for Pulmonary Function Testing in ALS Patients No drug interventions Not Available Not Available completed NCT05271435
Digital Tools for Assessment of Motor Functions and Falls in ALS No drug interventions Not Available Not Available recruiting NCT03506425
A Pilot Trial of Triheptanoin for People With Amyotrophic Lateral Sclerosis (PALS) treatment 1 / 2 completed NCT01984957
Differential Study of Muscle Transcriptome No drug interventions diagnostic Not Available completed NCT05635266
Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives No drug interventions Not Available Not Available recruiting NCT02819765
Deep Phenotyping in Patients With ALS No drug interventions Not Available Not Available completed NCT03865420
Amyotrophic Lateral Sclerosis (ALS) Families Project No drug interventions Not Available Not Available recruiting NCT05913882
Combined Respiratory Training in Persons With ALS No drug interventions treatment Not Available recruiting NCT05683860
Open-label Extension (OLE) Study of WVE-004 in Patients With C9orf72-associated Amyotrophic Lateral Sclerosis (ALS) and/or Frontotemporal Dementia (FTD) No drug interventions treatment 1 / 2 terminated NCT06215391
Customized Masks in Non-Invasive Mechanical Ventilation No drug interventions treatment Not Available recruiting NCT02716662
Safety of Caprylic Triglycerides in ALS: A Pilot Study No drug interventions treatment Not Available completed NCT02429492
Spinal Interneuron Excitability in ALS No drug interventions basic_science Not Available unknown_status NCT01124292
Evaluation of a Tongue Operated Assistive Technology for Individuals With Severe Paralysis No drug interventions supportive_care 1 completed NCT01393444
ECoG Direct Brain Interface for Individuals With Upper Limb Paralysis No drug interventions Not Available Not Available completed NCT04270604
Biological Sample Collection for Research and Biobanking No drug interventions Not Available Not Available terminated NCT06453668
A Study of TCD601 (Siplizumab) in Newly Diagnosed Adult Amyotrophic Lateral Sclerosis (ALS) Patients basic_science 1 active_not_recruiting NCT03373981
Non-invasive Brain Stimulation for the Treatment of Depression Symptoms in ALS No drug interventions treatment Not Available terminated NCT01785550
Neuromuscular Ultrasound in ALS No drug interventions Not Available Not Available completed NCT00076154
National Registry of Veterans With Amyotrophic Lateral Sclerosis and DNA Bank No drug interventions Not Available Not Available completed NCT05031351
NF-κB Inhibition in Amyotrophic Lateral Sclerosis No drug interventions treatment 2 unknown_status NCT03886753
Pharmacokinetic (PK) and Pharmacodynamics (PD) Study of Ilera Specific Products No drug interventions Not Available Not Available terminated NCT01962311
Evaluation of Metabolomic Analysis in Early Diagnosis of ALS No drug interventions diagnostic Not Available completed NCT04987671
Pharmacokinetic and Pharmacodynamic Study of AMX0035 in Patients With ALS No drug interventions treatment 1 / 2 active_not_recruiting NCT02525471
A Pilot Study of RNS60 in Amyotrophic Lateral Sclerosis (ALS) No drug interventions treatment 1 completed NCT02495571
Assessment of Voluntary and Reflex Cough in Patients With ALS No drug interventions diagnostic Not Available unknown_status NCT02457715
Feasibility of a Consumer Based Accelerometer in Monitoring Outpatient Physical Activity: A Study in Patients With Cancer and Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available completed NCT00696332
Talampanel for Amyotrophic Lateral Sclerosis (ALS) treatment 2 completed NCT03698149
ECoG BMI for Motor and Speech Control No drug interventions device_feasibility Not Available recruiting NCT03019419
Perampanel for Sporadic Amyotrophic Lateral Sclerosis (ALS) treatment 2 completed NCT05377424
Adenosine 2A Receptor Antagonism and AIH in ALS treatment 1 / 2 recruiting NCT04490148
Remote Pulmonary Function Testing and Nurse Coaching in ALS No drug interventions health_services_research Not Available completed NCT04396873
PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease diagnostic 1 recruiting NCT01035476
Optimizing NIPPV Use for Patients With ALS No drug interventions supportive_care Not Available completed NCT04931862
Study of WVE-004 in Patients With C9orf72-associated Amyotrophic Lateral Sclerosis (ALS) or Frontotemporal Dementia (FTD) No drug interventions treatment 1 / 2 terminated NCT04204889
Trial of Oxaloacetate in ALS treatment 1 completed NCT00340301
Exposure to Neurotoxins as Risk Factors for ALS No drug interventions Not Available Not Available completed NCT02756104
T Cell Phenotypes in Amyotropic Lateral Sclerosis (ALS), Influence of Vitamin D No drug interventions diagnostic Not Available completed NCT04138095
Virtual Reality as an Adjunct to Management of Pain and Anxiety in Palliative Care No drug interventions treatment Not Available unknown_status NCT03472950
Safety and Efficacy of Ranolazine for the Treatment of Amyotrophic Lateral Sclerosis treatment 2 recruiting NCT05966038
ALS/MND Natural History Study Data Repository No drug interventions Not Available Not Available recruiting NCT01786603
Rasagiline in Subjects With Amyotrophic Lateral Sclerosis (ALS) treatment 2 completed NCT01945853
Magnetic Resonance Imaging (MRI) in Amyotrophic Lateral Sclerosis (ALS) No drug interventions diagnostic Not Available withdrawn NCT02588677
Masitinib in Combination With Riluzole for the Treatment of Patients Suffering From Amyotrophic Lateral Sclerosis (ALS) treatment 2 / 3 completed NCT04055532
Biomarkers in Neurodegenerative Diseases No drug interventions Not Available Not Available withdrawn NCT02537132
"New Perspectives of Adaptation to NIV in ALS" No drug interventions treatment Not Available completed NCT01592552
A Biospecimen and Clinical Data Study on Patients for Drug & Biomarker Discovery No drug interventions Not Available Not Available completed NCT02469675
Brain and Nerve Stimulation for Hand Muscles in Spinal Cord Injury and ALS No drug interventions basic_science Not Available completed NCT01776970
Safety and Efficacy on Spasticity Symptoms of a Cannabis Sativa Extract in Motor Neuron Disease supportive_care 2 / 3 completed NCT01605006
Humanitarian Device Exemption Post-Approval Study of NeuRx Diaphragm Pacing System for Amyotrophic Lateral Sclerosis No drug interventions treatment Not Available completed NCT00420719
Motor-Point Stimulation for Conditioning the Diaphragm of Patients With Amyotrophic Lateral Sclerosis (ALS) No drug interventions treatment Not Available unknown_status NCT00415519
Efficacy and Safety Study of MCI-186 for Treatment of Amyotrophic Lateral Sclerosis (ALS) Who Met Severity Classification III treatment 3 completed NCT05395624
Safety, PK and Biodistribution of 18F-OP-801 in Patients With ALS, AD, MS, PD and Healthy Volunteers No drug interventions diagnostic 1 / 2 recruiting NCT03800524
Safety and Efficacy of TUDCA as add-on Treatment in Patients Affected by ALS treatment 3 active_not_recruiting NCT04505358
Evaluate PU-AD in Subjects With Amyotrophic Lateral Sclerosis No drug interventions treatment 2 withdrawn NCT01803386
Noninvasive Assessment of Neuromuscular Disease Using Electrical Impedance Myography No drug interventions Not Available Not Available completed NCT00069186
Study of Creatine Monohydrate in Patients With Amyotrophic Lateral Sclerosis No drug interventions treatment 3 unknown_status NCT01492686
Phase 3 Study of MCI-186 for Treatment of Amyotrophic Lateral Sclerosis treatment 3 completed NCT03088839
Circulating Biomarker for Amyotrophic Lateral Sclerosis (ALS) No drug interventions Not Available Not Available recruiting NCT02365922
Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL) No drug interventions Not Available Not Available completed NCT01835782
Determining the Safety of L-serine in ALS treatment 1 / 2 unknown_status NCT03755167
A Follow up Study to Protocol 101/2 - Continued Treatment by IPL344 IV treatment 2 suspended NCT00403104
Placebo Controlled Study of ONO2506PO in the Presence of Riluzole in Patients With Amyotrophic Lateral Sclerosis (ALS) treatment 2 completed NCT00876772
Olanzapine for the Treatment of Appetite Loss in Amyotrophic Lateral Sclerosis (ALS) treatment 2 / 3 completed NCT02559869
Imaging and BioFluid Biomarkers in Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available completed NCT00214110
Tamoxifen Therapy in Amyotrophic Lateral Sclerosis [ALS] Not Available 2 completed NCT06583395
Quest to Analyze One Thousand Humans Meditating No drug interventions Not Available Not Available enrolling_by_invitation NCT01232738
Trial of Safety and Efficacy of Rasagiline in Patients With Amyotrophic Lateral Sclerosis (ALS) treatment 2 completed NCT01699451
DNA, Blood and Skin Cell Repository for Research on ALS and Related Neurodegenerative Disorders at Mayo Clinic Florida No drug interventions Not Available Not Available completed NCT02118805
Innovative Measures of Speech and Swallowing Dysfunction in Neurological Disorders No drug interventions Not Available Not Available completed NCT02236897
PET Imaging in ALS Patients No drug interventions diagnostic Not Available completed NCT04866771
Remotely Supervised tDCS for Slowing ALS Disease Progression No drug interventions treatment Not Available active_not_recruiting NCT01884571
Immunosuppression in Amyotrophic Lateral Sclerosis (ALS) treatment 2 completed NCT03280056
Safety and Efficacy of Repeated Administrations of NurOwn® in ALS Patients treatment 3 completed NCT01277315
Safety and Tolerability of Anakinra in Combination With Riluzol in Amyotrophic Lateral Sclerosis treatment 2 completed NCT00821132
Genetics of Familial and Sporadic ALS No drug interventions Not Available Not Available completed NCT02152449
Oral Nutritional Supplementation in Amyotrophic Lateral Sclerosis (ALS) Patients No drug interventions treatment Not Available completed NCT02759913
A Study to Evaluate the Performance of a Diagnostic Test in ALS No drug interventions Not Available Not Available unknown_status NCT00444613
A Study in Patients With Amyotrophic Lateral Sclerosis (ALS) treatment 2 / 3 completed NCT00694941
A Phase II Multi-centre, Extension Study to Investigate the Long Term Safety of ONO-2506PO in Patients Diagnosed With Amyotrophic Lateral Sclerosis (ALS) treatment 2 completed NCT03580616
Tolerability and Efficacy of L-Serine in Patients With Amyotrophic Lateral Sclerosis (ALS) treatment 2 terminated NCT02936635
A Study for Patients Who Completed VITALITY-ALS (CY 4031) treatment 3 completed NCT00424463
Expanded Controlled Study of Safety and Efficacy of MCI-186 in Patients With Amyotrophic Lateral Sclerosis (ALS) treatment 3 completed NCT02463825
A Registry-Based Clinical Trial of Pimozide in Patients With Neuromuscular Junction Transmission Dysfunction Due to ALS treatment 2 unknown_status NCT04244630
Mitochondrial Capacity Boost in ALS (MICABO-ALS) Trial No drug interventions treatment 2 unknown_status NCT02414230
F 18 T807 Tau PET Imaging in Familial Amyotrophic Lateral Sclerosis Not Available Not Available completed NCT01806857
Clinical Trial Nuedexta in Subjects With ALS treatment 2 completed NCT01363882
Polysomnography-directed Noninvasive Ventilation in Amyotrophic Lateral Sclerosis (ALS) No drug interventions supportive_care Not Available terminated NCT05995782
A Phase 1, SAD and MAD Study to Evaluate the Safety and Tolerability of FB418 No drug interventions treatment 1 not_yet_recruiting NCT03645031
Acute Intermittent Hypoxia and Breathing in Neuromuscular Disease No drug interventions treatment Not Available completed NCT01366027
PRISM Registry: Pseudobulbar Affect Registry Series No drug interventions Not Available Not Available completed NCT06351592
First in Human (FIH) Study of ALN-SOD in Adult Participants With Amyotrophic Lateral Sclerosis Associated With Mutation in the SOD1 Gene (SOD1-ALS) No drug interventions treatment 1 not_yet_recruiting NCT00244244
A Multicenter, Dose Ranging Safety and Pharmacokinetics Study of Arimoclomol in ALS treatment 2 completed NCT00231140
Pilot-Study of Thalidomide in Amyotrophic Lateral Sclerosis (ALS) treatment 2 terminated NCT04577404
Safety Extension Study of Oral Edaravone Administered in Subjects With Amyotrophic Lateral Sclerosis (ALS) treatment 3 completed NCT00445172
A Long-Term Study in Patients With Amyotrophic Lateral Sclerosis (ALS) treatment 2 / 3 completed NCT02424669
Neuroinflammation in Amyotrophic Lateral Sclerosis - Mechanisms and Therapeutic Perspectives: a Translational Pilot Study Among ALS Patients No drug interventions Not Available Not Available unknown_status NCT03233646
Retinal Imaging in Neurodegenerative Disease No drug interventions Not Available Not Available recruiting NCT02017912
Phase 2, Randomized, Double Blind, Placebo Controlled Multicenter Study of Autologous MSC-NTF Cells in Patients With ALS treatment 2 completed NCT01746381
Non-invasive Ventilation in Amyotrophic Lateral Sclerosis (ALS) Using the iVAPS Mode No drug interventions treatment Not Available completed NCT00330681
Efficacy and Safety Study of MCI-186 for Treatment of Amyotrophic Lateral Sclerosis (ALS) treatment 3 completed NCT01938495
Diaphragm Pacing System (DPS) In Participants With Amyotrophic Lateral Sclerosis (ALS) No drug interventions supportive_care 2 completed NCT04090684
Ciprofloxacin/Celecoxib Combination in Patients With ALS treatment 1 completed NCT03241784
T-Regulatory Cells in Amyotrophic Lateral Sclerosis treatment 1 unknown_status NCT02164253
Focal Accumulation of Iron in Cerebral Regions in Early ALS (Amyotrophic Lateral Sclerosis) Patients supportive_care 2 completed NCT02286011
Intramuscular Infusion of Autologous Bone Marrow Stem Cells in Patients With Amyotrophic Lateral Sclerosis No drug interventions treatment 1 unknown_status NCT02528071
Prognostic Value of a Diaphragmatic Endurance Test in Patients With Amyotrophic Lateral Sclerosis No drug interventions Not Available Not Available terminated NCT00786032
A Clinical Demonstration of EEG Brain-computer Interface for ALS Patients No drug interventions Not Available Not Available completed NCT02709330
ALS Reversals - Lunasin Regimen treatment 2 completed NCT04849065
Clinical Trial on the Use of Cell Therapy in the Treatment of Patients With Amyotrophic Lateral Sclerosis No drug interventions treatment 2 unknown_status NCT03787420
Development and Needs Assessment and Efficiency of Smart Communication System for Patients With ALS. No drug interventions other Not Available unknown_status NCT02891629
Safety and Feasibility of the EyeControl Device No drug interventions supportive_care Not Available completed NCT04055623
T-regulatory Cells in ALS treatment 2 unknown_status NCT05663008
Impairments of Neuro-muscular Communication in Motor-Neuron Disease: A Bio-Marker for Early and Personalised Diagnosis No drug interventions Not Available Not Available recruiting NCT03330353
Chromatic Pupillometry to Assess the Melanopsin-Light Pathway in Progressive Supranuclear Palsy No drug interventions Not Available Not Available unknown_status NCT05276349
Home-based Remote Digital Monitoring to Assess ALS Progression (Track ALS) No drug interventions Not Available Not Available active_not_recruiting NCT03482050
A Study to Evaluate Transplantation of Astrocytes Derived From Human Embryonic Stem Cells, in Patients With Amyotrophic Lateral Sclerosis (ALS) treatment 1 / 2 completed NCT03081338
A Programme for Amyotrophic Lateral Sclerosis Care in Europe No drug interventions Not Available Not Available unknown_status NCT04715399
UPenn Observational Research Repository on Neurodegenerative Disease No drug interventions Not Available Not Available recruiting