Amyotrophic Lateral Sclerosis (ALS) (DBCOND0029898)

Identifiers

Synonyms
Amyotrophic Lateral Sclerosis ALS / ALS - Amyotrophic Lateral Sclerosis / Motor Neuron Disease, Amyotrophic Lateral Sclerosis / Amyotrophic Lateral Sclerosis / Lateral Amyotrophic Sclerosis / Lou Gehrig Disease / ALS / Lou-Gehrigs Disease / Lou Gehrig's Disease / ALS (Amyotrophic Lateral Sclerosis) / Amyotrophic lateral sclerosis(ALS) / Lou Gehrigs Disease / Amyotrophic lateral sclerosis (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Edaravone
A free radical scavenger used to delay the progression of ALS.
Phenylbutyric acid
An agent indicated for the adjunctive therapy for the management of chronic urea cycle disorders due to deficiencies in specific enzymes, including the neonatal-onset deficiency and late-onset disease with a history of hyperammonemic encephalopathy.
Riluzole
A glutamate antagonist used to treat amyotrophic lateral sclerosis.
Tauroursodeoxycholic acid
The taurine conjugate of ursodeoxycholic acid with antiapoptotic and ER stress response dampening effects used in some countries to treat gallstones. It is also being investigated for a wide variety of other conditions.
Tofersen
An antisense oligonucleotide indicated for the treatment of adult amyotrophic lateral sclerosis caused by SOD1 mutation.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT06493279
Evaluate the Safety and Efficacy of Intrathecal Injection of RJK002 in Patients With Amyotrophic Lateral SclerosisNo drug interventionstreatment1not_yet_recruiting
NCT06429059
ROAR-DIGAP: A Widely Inclusive, Largely Virtual Pilot Trial Utilizing DIGAP (Deep Integrated Genomics Analysis Platform) To Personalize Treatmentstreatment2enrolling_by_invitation
NCT06649955
Controlling Amyotrophic Lateral Sclerosis Motor Neuron Excitability StudyNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT06199284
Atalante Exoskeleton in the Rehabilitation of Patients With Amyotrophic Lateral SclerosisNo drug interventionsotherNot Availablerecruiting
NCT05852405
Clinical Characteristics, Natural History, Health Care Measures, and Genetic Screening in Patients With ALSNo drug interventionsNot AvailableNot Availablerecruiting
NCT04302870
Motor Neurone Disease - Systematic Multi-Arm Adaptive Randomised Trialtreatment2 / 3recruiting
NCT03604822
Music Therapy Protocol to Support Bulbar and Respiratory Functions in ALSNo drug interventionshealth_services_researchNot Availableunknown_status
NCT06320444
Non-invasive Spinal, Cortical, and Sensorimotor Biomarkers in Motor Neurone DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT05299372
Telemonitoring in NIV MND (OptNIVent)No drug interventionssupportive_careNot Availableunknown_status
NCT03537807
Expanded Access Protocol of BHV-0223 for Patients With Amyotrophic Lateral Sclerosis (ALS)Not AvailableNot Availableno_longer_available
NCT03520517
Open-label Study to Evaluate Safety, Tolerability and PK of BHV-0223 in ALSNo drug interventionstreatment1completed
NCT03100110
NeuroCognitive Communicator: Safety StudyNo drug interventionsdevice_feasibilityNot Availableunknown_status
NCT03828123
Autologous Multipotent Mesenchymal Stromal Cells in the Treatment of Amyotrophic Lateral SclerosisNo drug interventionstreatment1 / 2completed
NCT03225144
Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal DementiaNo drug interventionsNot AvailableNot Availablerecruiting
NCT03578796
Edinburgh Cognitive and Behavioural Amyotrophic Lateral Sclerosis Screen in Norway: A Prospective Cohort StudyNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT03579017
Edinburgh Cognitive and Behavioural Amyotrophic Lateral Sclerosis Screen in Norway: A Validation StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT06668649
Polish Version Fatigue Severity ScaleNo drug interventionsNot AvailableNot Availablerecruiting
NCT05407428
A Prospective Study to Evaluate the Correlation Between Oculometric Measurements and Clinical Endpoints in ALS PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT05744310
Effects of Long Term Ventilation Support on the Quality of Life of ALS Patients and Their FamiliesNo drug interventionstreatmentNot Availablerecruiting
NCT06365216
ALS Phase II Study of NX210cNo drug interventionstreatment2recruiting
NCT06429735
Precise Robotically IMplanted Brain-Computer InterfacENo drug interventionsdevice_feasibilityNot Availablerecruiting
NCT06441682
A Safety and Efficacy Study of ARGX-119 in Adult Patients with Amyotrophic Lateral Sclerosis (ALS)treatment2recruiting
NCT06491732
EIM Via the Myolex mScan as an ALS BiomarkerNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT06598202
Exploring Nasal Drop Therapy With Small Extracellular Vesicles for ALStreatment1 / 2recruiting
NCT06658977
RolloverTreatment with Triumeq for People with ALS Following the Lighthouse II Trialtreatment3not_yet_recruiting
NCT06656702
Effects of Psilocybin in Patients With Amyotrophic Lateral Sclerosistreatment0not_yet_recruiting
NCT04057898
Evaluation of MN-166 (ibudilast) for 12 Months Followed by an Open-label Extension for 6 Months in Patients with ALStreatment2 / 3recruiting
NCT04695210
Virtual Peer-to-peer Support Programme for Carers of MNDNo drug interventionssupportive_careNot Availablerecruiting
NCT05633459
A Study Evaluating the Safety and Tolerability of QRL-201 in ALSNo drug interventionstreatment1recruiting
NCT06169176
RAPA-501 Therapy for ALS Expanded Access ProtocolNo drug interventionsNot AvailableNot Availableavailable
NCT05336760
Dysphagia, QoL and Attitudes Towards PEG in ALS PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT06100276
Safety, Tolerability, and Exploratory Efficacy Study of Intrathecally Administered Gene Therapy AMT-162 in Adult Participants with SOD1 Amyotrophic Lateral Sclerosis (SOD1-ALS)treatment1 / 2recruiting
NCT06126315
Trial on the Biological and Clinical Effects of Acetyl-L-carnitine in ALStreatment2 / 3not_yet_recruiting
NCT06578195
ASSESS ALL ALS StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT04749433
Study of [11C]CPPC to Assess the Safety and Tolerability in Patients With ALSNo drug interventionsdiagnostic1terminated
NCT05193994
Triumeq in Amyotrophic Lateral Sclerosistreatment3active_not_recruiting
NCT06206629
Contralateral R1 in Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availablecompleted
NCT01925196
Natural History and Biomarkers of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Caused by the C9ORF72 Gene MutationNo drug interventionsNot AvailableNot Availablecompleted
NCT04097158
Biomarkers in Different Types of Amyotrophic Lateral Sclerosis (ALS) Patients Being Treated With EdaravoneNo drug interventionsNot AvailableNot Availablerecruiting
NCT04562831
The NO-ALS Study: a Trial of Nicotinamide/pterostilbene Supplement in ALS.No drug interventionstreatmentNot Availablerecruiting
NCT04745299
Evaluation the Efficacy and Safety of Mutiple Lenzumestrocel (Neuronata-R® Inj.) Treatment in Patients With ALStreatment3active_not_recruiting
NCT04889898
Remote Speech and Swallowing Assessment in ALSNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT05189106
Neurodegenerative Alzheimer's Disease and Amyotrophic Lateral Sclerosis (NADALS) Basket Trialtreatment1 / 2active_not_recruiting
NCT05349721
Study to Assess the Effects of PTC857 Treatment in Participants With Amyotrophic Lateral Sclerosis ALSNo drug interventionstreatment2active_not_recruiting
NCT05882695
Study of SPG302 in Healthy Volunteers and ALS Participantstreatment1active_not_recruiting
NCT04768972
FUSION: A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of ION363 in Amyotrophic Lateral Sclerosis Participants With Fused in Sarcoma Mutations (FUS-ALS)treatment3recruiting
NCT06605612
Development and Validation of the FBIndex to Determine the Risk of Falls for Patients with Neuromuscular DisordersNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT04948645
A Phase 1 Study to Investigate the Safety and Pharmacokinetics of Fosigotifator in Patients With Amyotrophic Lateral Sclerosistreatment1active_not_recruiting
NCT05006352
A Study to Determine the Safety, Pharmacokinetics, and Pharmacodynamics of DNL343 in Participants With Amyotrophic Lateral Sclerosistreatment1completed
NCT05178810
Study to Investigate the Efficacy and Safety of FAB122 (Daily Oral Edaravone) in Patients With Amyotrophic Lateral SclerosisNo drug interventionstreatment3completed
NCT05498883
Quality of Life Evaluation with the SRI Questionnaire of ALS Patient with Non-invasive VentilationNo drug interventionssupportive_careNot Availablecompleted
NCT06608719
Retrospective Study on the Safety and Therapeutic/Improvement Effects of Intravenous Administration of SHED-CM for ALS (SHED-CAH2023)No drug interventionsNot AvailableNot Availablecompleted
NCT06609213
Oral Intake of Enteral Nutrition Formula Preceding Placement and Feeding Via GTube and Its Impact on Formula Intolerance in PALSNo drug interventionspreventionNot Availablenot_yet_recruiting
NCT05983211
Quantitative and Repetitive TMS in ALS - Recruiting for Stage 2No drug interventionstreatmentNot Availablerecruiting
NCT06119087
Mechanical Insufflation in the Philadelphia Amyotrophic Lateral Sclerosis Cohort (MI-PALS) StudyNo drug interventionssupportive_careNot Availablerecruiting
NCT06581861
PREVENT ALL ALS StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT06596746
Neurodegenerative Diseases Progression Markers (MARKERS-NDD)No drug interventionsNot AvailableNot Availablerecruiting
NCT02759003
Nightime NIV Initiation in Amyotrophic Lateral Sclerosis in an Outpatient SettingNo drug interventionstreatmentNot Availablecompleted
NCT03272503
A Clinical Trial of Pimozide in Patients With Amyotrophic Lateral Sclerosis (ALS)treatment2unknown_status
NCT03464903
Study of ALS Reversals 2: Genetic AnalysesNo drug interventionsNot AvailableNot Availablecompleted
NCT02405403
Microglial Activation Role In ALS (MARIA)No drug interventionsdiagnostic0withdrawn
NCT01495390
A Longitudinal Study of Amyotrophic Lateral Sclerosis (ALS) BiomarkersNo drug interventionsNot AvailableNot Availablecompleted
NCT03792490
Inhibition of Rho Kinase (ROCK) With Fasudil as Disease-modifying Treatment for ALStreatment2completed
NCT03150290
Brown Adipose Tissue in ALSNo drug interventionsotherNot Availablecompleted
NCT04220190
RAPA-501 Therapy for ALSNo drug interventionstreatment2 / 3not_yet_recruiting
NCT02574390
Answer ALS: Individualized Initiative for ALS DiscoveryNo drug interventionsNot AvailableNot Availablecompleted
NCT00204464
Study of the Effects Strengthening Exercises in Individuals With ALSNo drug interventionstreatment2completed
NCT00386464
Noninvasive Ventilation in ALS Patients With Mild Respiratory InvolvementNo drug interventionssupportive_care2 / 3completed
NCT06528964
Proteinopathies Expression in Skin of Neurodegenerative DisordersNo drug interventionsNot AvailableNot Availablerecruiting
NCT00409721
The Effect of Memantine on Functional Outcomes and Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis (ALS)treatment2completed
NCT05003921
Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cell Intrathecal Injection for ALSNo drug interventionstreatment1suspended
NCT01948102
Identification of Diagnostic And Prognostic Biomarkers From Amyotrophic Lateral Sclerosis (ALS) Skin and Adipose SamplesNo drug interventionsNot AvailableNot Availablecompleted
NCT01459302
Genetic Study of Familial and Sporadic ALS/Motor Neuron Disease, Miyoshi Myopathy and Other Neuromuscular DisordersNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT02479802
Efficacy and Safety of Plasma Exchange With Albumin in Patients With Amyotrophic Lateral Sclerosistreatment2completed
NCT00337402
Effects of Gastrostomy on Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availablecompleted
NCT03851302
Effects of Remote Ischemic Conditioning on Hand Use in Individuals With Spinal Cord Injury and Amyotrophic Lateral SclerosisNo drug interventionsbasic_scienceNot Availablecompleted
NCT04363684
ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)No drug interventionsNot AvailableNot Availablerecruiting
NCT04944784
A Study to Evaluate the Efficacy and Safety of Reldesemtiv in Patients With Amyotrophic Lateral Sclerosis (ALS)treatment3terminated
NCT05945784
Exploring Accessible Beauty for Individuals With Upper Extremity DeficitsNo drug interventionsNot AvailableNot Availablecompleted
NCT05281484
Two Intermediate Expanded Access Protocols (EAP) CNMAu8.EAP01 and CNMAu8.EAP02 for ALSNot AvailableNot Availableavailable
NCT06083584
Development of Targeted RNA-Seq for Amyotrophic Lateral Sclerosis DiagnosisNo drug interventionsNot AvailableNot Availablerecruiting
NCT01592084
Hyperlipidemia and Statin Therapy in Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availablecompleted
NCT03945279
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BIIB100 Administered Orally to Adults With Amyotrophic Lateral SclerosisNo drug interventionstreatment1completed
NCT05067179
Analysis of Human ALS Tissues and Registry of ALS PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT02572479
Evaluating the Potential of the Diet as Disease Modifier in Amyotrophic Lateral Sclerosis (JERN_ALS)No drug interventionsNot AvailableNot Availablecompleted
NCT05974579
Safety and Dosimetry of a New Radiotracer to Detect Misfolded SOD1 Associated With Amyotrophic Lateral SclerosisNo drug interventionsdiagnostic1recruiting
NCT00372879
Clinical Trial of Vitamin E to Treat Muscular Cramps in Patients With ALSNo drug interventionstreatment3completed
NCT05297487
Evaluation of the Early Use of the Pressure Relaxer in the Respiratory Impairment of Patients With Amyotrophic Lateral Sclerosis: Multicenter Randomized Controlled Study.No drug interventionsotherNot Availablenot_yet_recruiting
NCT03912987
TRIAL READY (Clinical Trial Readiness)No drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT04950933
The Treatment of Amyotrophic Lateral Sclerosis With Huollingshengji Granulestreatment2 / 3unknown_status
NCT00839033
Evaluation of a Mechanical Device During Acute Respiratory Failure in Patients With Neuromuscular DisordersNo drug interventionstreatment3terminated
NCT00011154
Exogenous Toxicants and Genetic Susceptibility in ALSNo drug interventionsNot AvailableNot Availablecompleted
NCT03068754
Study of Acthar® Gel (Acthar) for Amyotrophic Lateral Sclerosis (ALS)treatment2 / 3terminated
NCT03757351
Study to Evaluate DNL747 in Subjects With Amyotrophic Lateral SclerosisNo drug interventionstreatment1terminated
NCT01348451
Human Spinal Cord Derived Neural Stem Cell Transplantation for the Treatment of Amyotrophic Lateral SclerosisNo drug interventionstreatment1unknown_status
NCT01082653
Safety/Efficacy Study for the Treatment of Amyotrophic Lateral SclerosisNo drug interventionsdiagnostic1suspended
NCT00886977
Efficacy and Safety of YAM80 in Amyotrophic Lateral Sclerosis (ALS)No drug interventionstreatment2unknown_status
NCT03944447
Outcomes Mandate National Integration With Cannabis as Medicinetreatment2recruiting
NCT00706147
Phase II/III Randomized, Placebo-controlled Trial of Arimoclomol in SOD1 Positive Familial Amyotrophic Lateral Sclerosistreatment2 / 3completed
NCT03806647
Development and Needs Assessment and Efficiency of Smart Communication System for Patients With ALS (Part 1)No drug interventionsNot AvailableNot Availableunknown_status
NCT04797845
Patient's TeleMonitoring With Amyotrophic Lateral Sclerosis Treated by Non Invasive Ventilation at Home.No drug interventionsotherNot Availablecompleted
NCT04788745
Targeting Metabolic Flexibility in Amyotrophic Lateral Sclerosis (ALS)treatment2completed
NCT06391645
Nerve Growth Factor Encapsulated With 2-methacryloyloxyethyl Phosphorylcholine Nanocapsules in the Treatment of Amyotrophic Lateral Sclerosistreatment2 / 3not_yet_recruiting
NCT00159198
Amyotrophic Lateral Sclerosis and Frontotemporal DementiaNo drug interventionsNot AvailableNot Availableterminated
NCT04332198
Neurobiological and Immunological Mechanisms of Dyspnea in ALS (BIOPNEA)No drug interventionsotherNot Availablenot_yet_recruiting
NCT00302198
Amyotrophic Lateral Sclerosis Web Based Patient Care Database: ALSConnection.OrgNo drug interventionsNot AvailableNot Availablecompleted
NCT02893605
Study of Gene Polymorphisms Involved in the Metabolism and Action of Vitamin D in Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availablecompleted
NCT03652805
A Study of IPL344 in the Treatment of ALS Patientstreatment1 / 2suspended
NCT04998305
TJ-68 Clinical Trial in Patients With Amyotrophic Lateral Sclerosis (ALS) and Muscle CrampsNo drug interventionstreatment1 / 2active_not_recruiting
NCT00021697
Safety/Efficacy of AVP-923 in the Treatment of Emotional Lability (Uncontrolled Crying & Laughing) in Patients With ALSNo drug interventionstreatment3completed
NCT02988297
Nebulized RNS60 for the Treatment of Amyotrophic Lateral SclerosisNo drug interventionstreatment2not_yet_recruiting
NCT04436497
HEALEY ALS Platform Trial - Regimen A Zilucoplantreatment2 / 3completed
NCT04297683
HEALEY ALS Platform Trial - Master Protocoltreatment2 / 3active_not_recruiting
NCT01154283
Study of Standard Noninvasive Positive Pressure Ventilation (NIPPV) and Low Expiratory Pressure NIPPV in ALS PatientsNo drug interventionstreatmentNot Availablecompleted
NCT01285583
Safety Extension Study of TRO19622 in ALSNot Available2 / 3completed
NCT00983983
High Fat/High Calorie Trial in Amyotrophic Lateral SclerosisNo drug interventionstreatment2completed
NCT04798183
Geometrical Facial Deformation According to Posture in Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availableunknown_status
NCT05619783
Extension Study Evaluating The Safety And Tolerability of AMX0035treatment3enrolling_by_invitation
NCT06284161
QCT in ALS Diagnosis, Mechanistic Understanding and Follow-upNo drug interventionsdiagnosticNot Availablerecruiting
NCT02645461
Acetylcholine Receptors From Human Muscles as Pharmacological Target for ALSbasic_scienceNot Availablecompleted
NCT04391361
The Safety and Effectiveness of Cholinergic Receptor Block Therapy in the Treatment of ALStreatment2unknown_status
NCT01521728
Trial of Resistance and Endurance Exercise in Amyotrophic Lateral Sclerosis (ALS)No drug interventionssupportive_careNot Availablecompleted
NCT03548311
Clinical Trial of Ultra-high Dose Methylcobalamin for ALStreatment3unknown_status
NCT00718393
Compassionate Use of Ceftriaxone in Patients With Amyotrophic Lateral Sclerosis (ALS)No drug interventionsNot AvailableNot Availablecompleted
NCT02193893
Biological Treatment of Amyotrophic Lateral SclerosisNo drug interventionstreatment1unknown_status
NCT05176093
A 6-Month Extension Study to Assess the Long-Term Safety of Engensis in Amyotrophic Lateral Sclerosistreatment2completed
NCT02242071
Cell Therapy for Motor Neuron Disease/Amyotrophic Lateral SclerosisNo drug interventionstreatment1withdrawn
NCT00004771
Phase II Study of Leuprolide and Testosterone for Men With Kennedy's Disease or Other Motor Neuron Diseasetreatment2completed
NCT00753571
Cistanche Total Glycosides for Amyotrophic Lateral Sclerosis: A Randomized Control Trial (RCT) Study Assessing Clinical ResponseNo drug interventionstreatment2unknown_status
NCT03948178
Effects of Oral Levosimendan on Respiratory Function in Patients With Amyotrophic Lateral Sclerosis (ALS): Open-Label Extensiontreatment3terminated
NCT04820478
Efficacy and Tolerability of Beta Hydroxybutyrate Ester in Patients With Amyotrophic Lateral Sclerosis (ALS)No drug interventionstreatmentNot Availablerecruiting
NCT01449578
Dexpramipexole SAD/MAD Studytreatment1completed
NCT04798378
NuroSleeve Powered Brace & Stimulation System to Restore Arm FunctionNo drug interventionssupportive_careNot Availablerecruiting
NCT06337578
Advances in Telephone-based Cognitive Screening ProceduresNo drug interventionsNot AvailableNot Availablerecruiting
NCT03489278
Clinical Procedures to Support Research in ALSNo drug interventionsNot AvailableNot Availablerecruiting
NCT05979688
Yogic Breathing Exercise for People With Amyotrophic Lateral SclerosisNo drug interventionstreatmentNot Availablerecruiting
NCT01622088
Phase 3 Extension Study of Dexpramipexole in ALStreatment3terminated
NCT00718107
Satisfaction Survey for Amyotrophic Lateral Sclerosis (ALS) Patients Comparing Rooms With and Without Assistive TechnologyNo drug interventionsNot AvailableNot Availableterminated
NCT02487407
Effects of ODM-109 on Respiratory Function in Patients With Amyotrophic Lateral Sclerosistreatment2completed
NCT05837507
Amyotrophic Lateral Sclerosis Non-invasive Ventilation ExchangeNo drug interventionstreatmentNot Availablerecruiting
NCT03377309
Safety and Tolerability of Perampanel in Amyotrophic Lateral Sclerosis Patientstreatment2terminated
NCT02874209
Noninvasive Assessment of Neuronal Damage by MRI Sodium ( 23Na ) in Amyotrophic Lateral SclerosisNo drug interventionsdiagnosticNot Availableunknown_status
NCT04150809
A Study to Explore the Role of Gut Flora in ALSNo drug interventionsNot AvailableNot Availableunknown_status
NCT04559009
COVID-19 Amyotrophic Lateral Sclerosis (ALS) RegistryNo drug interventionsNot AvailableNot Availablecompleted
NCT01504009
Muscle Training of Patients With Amyotrophic Lateral Sclerosis (ALS)No drug interventionstreatmentNot Availablecompleted
NCT01142856
Mesenchymal Stem Cells for Treatment of Amyotrophic Lateral Sclerosis (ALS)No drug interventionstreatment1completed
NCT05951556
Telehealth Implementation of Brain-Computer InterfaceNo drug interventionssupportive_careNot Availablerecruiting
NCT04494256
A Study to Assess the Safety, Tolerability, and Effect on Disease Progression of BIIB105 in Participants With Amyotrophic Lateral Sclerosis (ALS) and Participants With the ALS Ataxin-2 (ATXN2) Genetic MutationNo drug interventionstreatment1 / 2active_not_recruiting
NCT06318585
Creation of a Clinical Database for the Study of Phenotypic Variability in Motor Neuron DiseasesNo drug interventionsNot AvailableNot Availablerecruiting
NCT02582385
In-situ Cytokines Expression in the CNS in Amyotrophic Lateral Sclerosis (ALS)No drug interventionsNot AvailableNot Availablecompleted
NCT00596115
Treating Amyotrophic Lateral Sclerosis (ALS) With R(+) Pramipexole Dihydrochloride Monohydrate at 60 mg/DayNot AvailableNot Availabletemporarily_not_available
NCT06209515
Sociodemographic Factors and Criminal Behaviour Preceding Neurodegenerative Disease - Retrospective Register StudyNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT03103815
Trial of Amivita in Amyotrophic Lateral SclerosisNo drug interventionstreatmentNot Availableunknown_status
NCT03114215
Effect of MD1003 in Amyotrophic Lateral Sclerosisother2completed
NCT03694132
Brain Excitability and Connectivity in Sensory-motor Pathways in ALSNo drug interventionsbasic_scienceNot Availableunknown_status
NCT00243932
Clinical Trial of High Dose CoQ10 in ALStreatment2completed
NCT04082832
CuATSM Compared With Placebo for Treatment of ALS/MNDtreatment2 / 3unknown_status
NCT04744532
iPSC-based Drug Repurposing for ALS Medicine (iDReAM) Studytreatment1 / 2recruiting
NCT04514952
Individual Patient Expanded Access IND of Autologous HBadMSCs for the Treatment of Amyotrophic Lateral SclerosisNot AvailableNot Availableno_longer_available
NCT00140452
Phase II Study Using Thalidomide for the Treatment of ALStreatment2completed
NCT02795052
Neurologic Stem Cell Treatment StudyNo drug interventionstreatmentNot Availablerecruiting
NCT00855400
Clinical Trial on the Use of Autologous Bone Marrow Stem Cells in Amyotrophic Lateral SclerosisNo drug interventionstreatment1 / 2completed
NCT00136500
Clinical Research in ALS StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT01954875
Establishment of a Human Tissue Bank for Studying the Microbial Etiology of Neurodegenerative DiseasesNo drug interventionsNot AvailableNot Availablewithdrawn
NCT04328675
Registration Study of Amyotrophic Lateral Sclerosis (ALS) in Mainland ChinaNo drug interventionsNot AvailableNot Availableunknown_status
NCT02675075
DESIPHER_Speech Degradation as an Indicator of Physiological Degeneration in ALSNo drug interventionsNot AvailableNot Availablecompleted
NCT02325375
sCD163 in ALS PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT05442775
A Phase 3, Open-Label Extension of COURAGE-ALS (CY 5031)treatment3terminated
NCT03378375
Resting Energy Expenditure Equations in Amyotrophic Lateral Sclerosis, Creation of a ALS-specific EquationNo drug interventionsNot AvailableNot Availablecompleted
NCT00613899
Feasibility of Telesurveillance and Home Cough Assistance for Amyotrophic Lateral Patients (ALS)No drug interventionstreatment4completed
NCT02623699
An Efficacy, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of BIIB067 (Tofersen) in Adults With Inherited Amyotrophic Lateral Sclerosis (ALS)treatment3completed
NCT03324399
A Study of Protein Metabolism, Microbiome and Investigational Probiotic Use in Patients With ALSNo drug interventionstreatmentNot Availablecompleted
NCT04233099
Salivary Biomarker Discovery by Raman Spectroscopy in ALS (SalivALS)No drug interventionsNot AvailableNot Availablerecruiting
NCT03085706
Transplantation of Autologous Peripheral Blood Mononuclear Cells for Amyotrophic Lateral SclerosisNo drug interventionstreatmentNot Availablecompleted
NCT04098406
Therapeutic Nanocatalysis to Slow Disease Progression of Amyotrophic Lateral Sclerosis (ALS)treatment2completed
NCT04380649
Development and Test of a Headset for BCI Until Obtaining an Efficient and Comfortable System That Can be Used in Daily Practice by ALS PeopleNo drug interventionsotherNot Availablerecruiting
NCT04322149
Multiple Doses of AT-1501-A201 in Adults With ALStreatment2completed
NCT06551649
Human Amniotic Mesenchymal Cell Secretome for Neurodegeneration and NeuroinflammationNo drug interventionsbasic_scienceNot Availablenot_yet_recruiting
NCT01536249
Dexpramipexole and Cimetidine Drug Drug Interaction (DDI)treatment1completed
NCT06008249
Platform Trial to Assess the Efficacy of Multiple Drugs in Amyotrophic Lateral Sclerosis (ALS)treatment3recruiting
NCT02714036
A Biomarker Study to Evaluate MN-166 (Ibudilast) in Subjects With Amyotrophic Literal Sclerosis (ALS)treatment1 / 2completed
NCT04947436
ALS and Airway Clearance (ALSAC) TherapyNo drug interventionstreatmentNot Availablecompleted
NCT00036413
A 12-week, Multicenter, Safety and Dose-ranging Study of 3 Oral Doses of TCH346 in Patients With Amyotrophic Lateral Sclerosistreatment2completed
NCT02000713
Cervical Spinal Cord Metabolism and Microstructure in Amyotrophic Lateral Sclerosis(ALS)No drug interventionsdiagnosticNot Availableterminated
NCT03567213
Investigation on the Cortical Communication (CortiCom) SystemNo drug interventionsdevice_feasibilityNot Availablerecruiting
NCT00690118
Study of Pioglitazone in Patients With Amyotrophic Lateral Sclerosistreatment2terminated
NCT00140218
R(+) Pramipexole in Early Amyotrophic Lateral Sclerosistreatment1 / 2completed
NCT04468919
Optimizing BCI-FIT: Brain Computer Interface - Functional Implementation ToolkitNo drug interventionsbasic_scienceNot Availablerecruiting
NCT00537641
Efficacy of Noninvasive Ventilation in Amyotrophic Lateral Sclerosis (ALS)No drug interventionsNot AvailableNot Availablecompleted
NCT00912041
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With TetraplegiaNo drug interventionsotherNot Availablerecruiting
NCT03237741
Bioavailability of GDC-0134 and the Effect of Food and Proton Pump Inhibitor on Pharmacokinetics of GDC-0134 in Healthy Female Participantstreatment1completed
NCT04721717
AIM's Writing for Healing: A Workshop for Individuals Living With ParalysisNo drug interventionsNot AvailableNot Availablerecruiting
NCT00838617
Muscle Ultrasound: A New Tool for Measuring Progression in Amyotrophic Lateral Sclerosis (ALS)No drug interventionsNot AvailableNot Availablecompleted
NCT03034317
NeuRx Diaphram Pacing System (DPS) Use in Amyotrophic Lateral Sclerosis (ALS)No drug interventionstreatmentNot Availablewithdrawn
NCT03488524
Open Label Extension Study of AMX0035 in Patients With ALSNo drug interventionstreatment2completed
NCT05407324
Dazucorilant in Patients With Amyotrophic Lateral Sclerosistreatment2active_not_recruiting
NCT00213824
A Study of the Expression of Nogo and Reticulon Genes in Skeletal Muscle of Patients With Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availableterminated
NCT04953624
Appetite and Related Factors in Patients With ALSNo drug interventionsNot AvailableNot Availableunknown_status
NCT02492516
Intravenous Injection of Adipose Derived Mesenchymal Stem Cell for ALSNo drug interventionstreatment1completed
NCT01730716
Dose Escalation and Safety Study of Human Spinal Cord Derived Neural Stem Cell Transplantation for the Treatment of Amyotrophic Lateral SclerosisNo drug interventionstreatment2unknown_status
NCT03836716
Arimoclomol in Amyotropic Lateral Sclerosis - Open Label Extension Trialtreatment3terminated
NCT04875416
Phenotype, Genotype and Biomarkers 2No drug interventionsNot AvailableNot Availablerecruiting
NCT04516096
A Compassionate Use Protocol of AMX0035 for Treatment of Patients With Amyotrophic Lateral Sclerosis (ALS)No drug interventionstreatment2 / 3completed
NCT00647296
Safety and Tolerability Study of KNS-760704 in Amyotrophic Lateral Sclerosis (ALS)treatment2completed
NCT04089696
Validation of the "ExSpiron©" in Patients With ALSNo drug interventionsbasic_scienceNot Availablenot_yet_recruiting
NCT02469896
A Trial of Tocilizumab in ALS Subjectstreatment2completed
NCT05352958
Contribution of Diaphragmatic Ultrasound for Monitoring Diaphragmatic Function in Patients With Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availablerecruiting
NCT05105958
Tideglusib for the Treatment of Amyotrophic Lateral Sclerosistreatment2not_yet_recruiting
NCT03192358
Physiological Flow of Liquids Used in Dysphagia Management (Neuro)No drug interventionsNot AvailableNot Availablecompleted
NCT04569435
Study of ANX005 in Adults With Amyotrophic Lateral Sclerosis (ALS)treatment2completed
NCT05474235
Studies in Amyotrophic Lateral Sclerosis (ALS) and Other Neurodegenerative Motor Neuron DisordersNo drug interventionsNot AvailableNot Availablerecruiting
NCT01424163
Dexpramipexole Japanese PK StudyNo drug interventionsbasic_science1completed
NCT03411863
Cervical Electrical Stimulation for ALSNo drug interventionsbasic_scienceNot Availablecompleted
NCT03474263
IC14 for Rapidly Progressive Amyotrophic Lateral Sclerosis (ALS)No drug interventionstreatment2withdrawn
NCT04499963
Trial of Theracurmin for Patients With Amyotrophic Lateral Sclerosis (ALS)No drug interventionstreatment2completed
NCT03892863
Repetitive Transcranial Magnetic Stimulation as Therapy for Depression in Amyotrophic Lateral SclerosisNo drug interventionstreatmentNot Availablewithdrawn
NCT05163886
Study of Safety, Tolerability, and Biological Activity of LAM-002A in C9ORF72-Associated Amyotrophic Lateral SclerosisNo drug interventionstreatment2active_not_recruiting
NCT03334786
Study to Evaluate Safety & Efficacy of FLX-787-ODT to Treat Fasciculations in Tongue and Appendicular Muscle in Adult Subjects With ALSNo drug interventionstreatment1 / 2terminated
NCT03427086
Safety and Tolerability of High Dose Biotin in Patients With Amyotrophic Lateral Sclerosistreatment2completed
NCT04953286
Ocular Surface Metabolo-lipidomics in Lateral Amyotrophic SclerosisNo drug interventionshealth_services_researchNot Availablecompleted
NCT03073239
Amyotrophic Lateral Sclerosis: a New ParadigmNo drug interventionsNot AvailableNot Availablecompleted
NCT04956822
Application of Motor Unit Estimation Index in Amyotrophic Lateral Sclerosis and Related DiseasesNo drug interventionsNot AvailableNot Availableunknown_status
NCT01016522
Safety and Tolerability of the Ketogenic Diet in Amyotrophic Lateral Sclerosis (ALS)No drug interventionstreatment3terminated
NCT06527222
A Study of Ranolazine in ALStreatment2not_yet_recruiting
NCT00007722
Amyotrophic Lateral Sclerosis (ALS) Gulf War StudyNo drug interventionsNot AvailableNot Availablecompleted
NCT03659422
Dietary Approach to Improving Quality of Life in Amyotrophic Lateral SclerosisNo drug interventionstreatmentNot Availablewithdrawn
NCT00349622
Clinical Trial Ceftriaxone in Subjects With ALStreatment3completed
NCT05892822
Amyotrophic Lateral Sclerosis RegistryNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT00326625
Clinical Trial of Glatiramer Acetate in Amyotrophic Lateral Sclerosis (ALS)treatment2completed
NCT04952025
Quantitative Analysis of Precise Brain Volume in Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availablecompleted
NCT01911130
Longitudinal Study of Outcomes Measures in ALS TrialsNo drug interventionsNot AvailableNot Availablecompleted
NCT01123148
A P300 Brain Computer Interface to Operate Power Wheelchair TiltNo drug interventionssupportive_careNot Availablecompleted
NCT06441448
potentiALS - Quality of Life Among Patients With Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availablerecruiting
NCT04889248
Inspiratory Muscle Training With Powerbreath Device in Patients With ALSNo drug interventionssupportive_careNot Availablecompleted
NCT05306457
CNS10-NPC-GDNF Delivered to the Motor Cortex for ALSNo drug interventionstreatment1recruiting
NCT05632757
Anticipated Patient and Caregiver BurdenNo drug interventionssupportive_careNot Availablerecruiting
NCT02794857
Safety and Efficacy Study of NP001 in Patients With Amyotrophic Lateral Sclerosis (ALS) and Systemic InflammationNo drug interventionstreatment2completed
NCT06181526
Safety and Preliminary Efficacy of Aleeto in Amyotrophic Lateral SclerosisNo drug interventionstreatment1not_yet_recruiting
NCT04800926
Xavier Electromyographic Wheelchair Control for Limited Mobility PatientsNo drug interventionsdevice_feasibilityNot Availablecompleted
NCT02916966
Environmental Exposure and Neurological Diseases QuestionnaireNo drug interventionsNot AvailableNot Availablecompleted
NCT04313166
Treatment Continuation Study for Patients With ALS/MND Who Completed Study CMD-2019-001treatment2completed
NCT00561366
A Multicenter, Double-Blind Study to Investigate the Safety and Efficacy of Arimoclomol in Volunteers With ALStreatment2withdrawn
NCT00868166
Safety and Efficacy of TRO19622 as add-on Therapy to Riluzole Versus Placebo in Treatment of Patients Suffering From ALSother3completed
NCT03573466
Presymptomatic Neuromuscular Junction Defects and Compensatory Mechanisms in ALSNo drug interventionsbasic_scienceNot Availableunknown_status
NCT05137665
Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home MeasuresNo drug interventionsNot AvailableNot Availablerecruiting
NCT01641965
Impact of Early Non Invasive Ventilation in Amyotrophic Lateral Sclerosis (ALS) PatientsNo drug interventionstreatmentNot Availablecompleted
NCT05716074
The Effect of Low-Ä°ntensity Combined Exercises in Patients With Early Stage ALS.No drug interventionstreatmentNot Availablerecruiting
NCT05508074
Treatment Combining Riluzole and IFB-088 in Bulbar Amyotrophic Lateral Sclerosis (TRIALS Protocol)treatment2active_not_recruiting
NCT01786174
Gilenya in Amyotrophic Lateral Sclerosis (ALS)treatment2completed
NCT04885374
China Amyotrophic Lateral Sclerosis Registry of Patients With Traditional Chinese MedicineNo drug interventionsNot AvailableNot Availablerecruiting
NCT06454682
An IIT Clinical Study to Evaluate the Safety and Efficacy of a Single Intrathecal Injection of RJK002 in Patients With Amyotrophic Lateral Sclerosis (ALS)No drug interventionstreatment0not_yet_recruiting
NCT01051882
Autologous Cultured Mesenchymal Bone Marrow Stromal Cells Secreting Neurotrophic Factors (MSC-NTF), in ALS Patients.No drug interventionstreatment1 / 2completed
NCT03892382
Repetitive Transcranial Magnetic Stimulation as Therapy for Apathy in Amyotrophic Lateral SclerosisNo drug interventionstreatmentNot Availablewithdrawn
NCT00790582
A Multi-Center Controlled Screening Trial of Safety and Efficacy of Lithium Carbonate in Subjects With Amyotrophic Lateral Sclerosis (ALS)treatment2completed
NCT04950231
Investigation on Home Care Needs of ALS Patients and Their CaregiversNo drug interventionsNot AvailableNot Availablecompleted
NCT06315673
Digital Assessment of Speech and Fine Motor Control in ALSNo drug interventionsNot AvailableNot Availablerecruiting
NCT03039673
MIROCALS: Modifying Immune Response and OutComes in ALStreatment2completed
NCT00600873
R(+)PPX High Dose Treatment of ALSNot Available1 / 2completed
NCT01959373
Dysfunctions and Plasticity Mechanisms of Motor System Assessed by Cortico-cortical and Cortico-muscular Coherence Analysis in Amyotrophic Lateral SclerosisNo drug interventionsdiagnosticNot Availablesuspended
NCT04104373
The Ontario Neurodegenerative Disease Research InitiativeNo drug interventionsNot AvailableNot Availablecompleted
NCT06408727
Intermediate Expanded Access Protocol CNMAu8.EAP04Not AvailableNot Availableavailable
NCT02118727
Therapy in Amyotrophic Lateral Sclerosis (TAME)treatment2completed
NCT04575727
Exploratory Evaluation of [11C]MPC6827No drug interventionsbasic_science0recruiting
NCT02590276
Predict to Prevent Frontotemporal Lobar Degeneration (FDT) and Amyotrophic Lateral Sclerosis (ALS)No drug interventionspreventionNot Availablecompleted
NCT01378676
A Study to Evaluate the Effects of Multiple Doses of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS)treatment2completed
NCT00846560
Involvement of Lymphocyte Type B in Amyotrophic Lateral Sclerosis (ALS)No drug interventionsNot AvailableNot Availablewithdrawn
NCT05340660
mGluR5 Imaging in ALS Using PETNo drug interventionsbasic_scienceNot Availablerecruiting
NCT06344260
Neural Stem Cell Treatment for Amyotrophic Lateral Sclerosis (STEMALS)No drug interventionstreatment2recruiting
NCT04953494
Pleiotropy and Mechanism of Peripheral Nerve Related Genes in the Progression of Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availableunknown_status
NCT03293394
Rehabilitative Trial With tDCS in Amyotrophic Lateral SclerosisNo drug interventionstreatmentNot Availablecompleted
NCT05949294
Study of AROSOD-1 in Adult Participants With Amyotrophic Lateral Sclerosis (ALS)No drug interventionstreatment1withdrawn
NCT03690791
Efficacy of Cannabinoids in Amyotrophic Lateral Sclerosis or Motor Neurone DiseaseNo drug interventionstreatment3active_not_recruiting
NCT02360891
Study of Predictive Factors of Progression of Motor Neurone DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT02288091
A Pilot Study of Inosine in Amyotrophic Lateral Sclerosis (ALS)treatment1completed
NCT03201991
ALS Study Determining Various Biomarkers and Strength Comparison After ExerciseNo drug interventionspreventionNot Availablecompleted
NCT01639391
Creation of a Bank of Fibroblast From Patients With Amyotrophic Lateral Sclerosis: Pilot StudyNo drug interventionsbasic_scienceNot Availablecompleted
NCT04468191
Fatigue in Patients With Amyotrophic Lateral SclerosisNo drug interventionstreatmentNot Availablewithdrawn
NCT01508962
PRE-Symptomatic Studies in Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT01384162
An Open Label, Safety and Tolerability Continuation Study of Intracerebroventricular Administration of sNN0029 to Patients With Amyotrophic Lateral Sclerosistreatment1 / 2terminated
NCT06230562
DIAGALS: Relation Between Tar DNA Binding Protein(TDP)-43 et Nrf-2 in ALS: a Track to Improve Diagnosis and Prognosis of the DiseaseNo drug interventionsdiagnosticNot Availablenot_yet_recruiting
NCT03536962
Multidisciplinary Follow-up of Patients With Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availableunknown_status
NCT02868580
Safety and Tolerability of Antiretroviral (Triumeq) in Patients With Amyotrophic Lateral Sclerosis (ALS).treatment2completed
NCT01823380
Influence of the Vitamin D Blood Levels on the Amyotrophic Lateral Sclerosis PhenotypeNo drug interventionsbasic_scienceNot Availablecompleted
NCT01494480
The Clinical Trial on the Use of Umbilical Cord Mesenchymal Stem Cells in Amyotrophic Lateral SclerosisNo drug interventionstreatment2unknown_status
NCT03095729
Cognitive Consequences of an Activation of the Cortical Drive to Breath (VENTIPSY)No drug interventionsNot AvailableNot Availablecompleted
NCT01992029
Study of miRNA Expression Pattern as Diagnostic and Prognostic Biomarker in Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availableterminated
NCT04762589
RT001 in Amyotrophic Lateral Sclerosistreatment2unknown_status
NCT01281189
Phase 3 Study of Dexpramipexole in ALStreatment3completed
NCT04654689
Impact of the Combined Treatment of Liposomed Polyphenols With G04CB02 on the ALS PatientsNo drug interventionssupportive_care2completed
NCT02881489
Autologous Bone Marrow Mesenchymal Stem Cells in the Treatment of Patients With Amyotrophic Lateral SclerosisNo drug interventionstreatment1unknown_status
NCT04454892
Natural History and Clinical Features of Amyotrophic Lateral Sclerosis (ALS)No drug interventionsNot AvailableNot Availablerecruiting
NCT05328492
Volume Mode Non-invasive Ventilation in Amyotrophic Lateral SclerosisNo drug interventionstreatmentNot Availablerecruiting
NCT05860244
Effect of Salbutamol on Walking Capacity in Ambulatory ALS Patientstreatment2not_yet_recruiting
NCT00931944
Open-Label, Safety and Tolerability Extension Study of KNS-760704 in Amyotrophic Lateral Sclerosis (ALS) (CL211)treatment2completed
NCT04066244
Study of Safety and of the Mechanism of BLZ945 in ALS Patientstreatment2terminated
NCT04226144
Breath Stacking Technique Associated With Expiratory Muscle Training in Amyotrophic Lateral Sclerosis PatientsNo drug interventionstreatmentNot Availableterminated
NCT04440644
Italian Validation of the Beaumont Behavioural Inventory (BBI)No drug interventionsNot AvailableNot Availablecompleted
NCT05981040
Efficacy, Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ZYIL1 in Patients With Amyotrophic Lateral Sclerosistreatment2active_not_recruiting
NCT01160367
Trial of Ascertaining Individual Preferences for Loved One's Role in End-of-LifeNo drug interventionssupportive_careNot Availablecompleted
NCT04393467
Transcranial Static Magnetic Field Stimulation (tSMS) in Amyotrophic Lateral Sclerosis (ALS).No drug interventionstreatmentNot Availableunknown_status
NCT03127267
Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patientstreatment3recruiting
NCT00956501
Assessment of Postural Orientation and Equilibrium In Early Amyotrophic Lateral Sclerosis (ALS)No drug interventionsNot AvailableNot Availablecompleted
NCT00877604
Efficacy and Tolerability of Tauroursodeoxycholic Acid in Amyotrophic Lateral Sclerosistreatment2completed
NCT04882904
Continuous Measurement of Activity in Patients With Muscle Pathology and in Control Subjects. ActiSLA Part.No drug interventionsotherNot Availablerecruiting
NCT06165172
Early Feasibility Study of the MyoRegulator® for Treatment of ALSNo drug interventionsdevice_feasibilityNot Availablerecruiting
NCT05286372
An Intermediate Size Expanded Access Protocol of AMX0035 for ALSNo drug interventionsNot AvailableNot Availableapproved_for_marketing
NCT05889572
Safety and Gut Microbiota Analysis of an Oral Microbiotherapy in Patients With Amyotrophic Lateral SclerosisNo drug interventionstreatment1active_not_recruiting
NCT03929068
Sinemet for Spasticity and Function in Amyotrophic Lateral Sclerosis and Primary Lateral Sclerosistreatment1completed
NCT00677768
Validation of Biomarkers in Amyotrophic Lateral Sclerosis (ALS)No drug interventionsNot AvailableNot Availablecompleted
NCT05106569
Telespirometry in Amyotrophic Lateral Sclerosis (ALS)No drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT06539169
FLOWER: Following Longitudinal Outcomes With Epidemiology for Rare DiseasesNo drug interventionsNot AvailableNot Availablerecruiting
NCT01955369
Amyotrophic Lateral Sclerosis Registry Rhineland-PalatinateNo drug interventionsNot AvailableNot Availablecompleted
NCT06513546
A Study to Evaluate the Safety, Efficacy, and Pharmacodynamics of PLL001 in ALS Patientstreatment1 / 2not_yet_recruiting
NCT04948346
Correlation Between Intestinal Microflora Metabolites and Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availablecompleted
NCT06418646
Patients' and Caregivers' Views of Multidimensional Care in Amyotropic Lateral Sclerosis in GermanyNo drug interventionsNot AvailableNot Availablerecruiting
NCT03049046
CC100: Phase 1 Multiple-Dose Safety and Tolerability in Subjects With ALSNo drug interventionstreatment1unknown_status
NCT00875446
First Time in Human Study of GSK1223249 in Amyotrophic Lateral Sclerosistreatment1completed
NCT03626012
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of BIIB078 in Adults With C9ORF72-Associated Amyotrophic Lateral SclerosisNo drug interventionstreatment1completed
NCT01089010
A Study of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS)treatment2completed
NCT03843710
31P-MRS Imaging to Assess the Effects of CNM-Au8 on Impaired Neuronal Redox State in Amyotrophic Lateral Sclerosis (REPAIR-ALS)treatment2withdrawn
NCT04686110
Analysis of Capillary Retinal and Papillary Vascularization in Patients With Amyotrophic Lateral Sclerosis - CAPISLANo drug interventionsotherNot Availableunknown_status
NCT01950910
Establishment of a Tissue Bank (Blood, CSF) for the Understanding of Motor Neuron Disease (MND)No drug interventionsNot AvailableNot Availableterminated
NCT01758510
Safety Study of HLA-haplo Matched Allogenic Bone Marrow Derived Stem Cell Treatment in Amyotrophic Lateral SclerosisNo drug interventionstreatment1completed
NCT02437110
HERV-K Suppression Using Antiretroviral Therapy in Volunteers With Amyotrophic Lateral Sclerosis (ALS)treatment1completed
NCT04026581
Real World Testing of a Brain-Computer InterfaceNo drug interventionsNot AvailableNot Availablecompleted
NCT03693781
Colchicine for Amyotrophic Lateral Sclerosistreatment2completed
NCT02917681
Study of Two Intrathecal Doses of Autologous Mesenchymal Stem Cells for Amyotrophic Lateral SclerosisNo drug interventionstreatment1 / 2unknown_status
NCT02655614
A Study of GDC-0134 to Determine Initial Safety, Tolerability, and Pharmacokinetic Parameters in Participants With Amyotrophic Lateral Sclerosistreatment1completed
NCT01984814
Stem Cell Therapy for Amyotrophic Lateral SclerosisNo drug interventionstreatment2withdrawn
NCT04259255
Radicava® (Edaravone) Findings in Biomarkers From ALS (REFINE-ALS)Not AvailableNot Availableactive_not_recruiting
NCT06215755
A Study of VRG50635 in Participants With Amyotrophic Lateral Sclerosis (ALS)No drug interventionstreatment1recruiting
NCT04952155
Low Dose IL-2 in the Treatment of Immune-associated ALS SyndromeNo drug interventionstreatment2unknown_status
NCT04651855
The Evaluation of the Effect of Mesenchymal Stem Cells on the Immune System of Patients With ALSNo drug interventionstreatment1 / 2unknown_status
NCT04819555
Frequency of SOD1 and C9orf72 Gene Mutations in French ALSNo drug interventionsNot AvailableNot Availablecompleted
NCT00919555
Combination Therapy in Amyotrophic Lateral Sclerosis (ALS)treatment1 / 2completed
NCT05357950
A Phase IIb, Multi-Center, Multinational, Double-Blind, Placebo-Controlled Study, With an Open Label Extension, to Evaluate Safety, Tolerability and Efficacy of PrimeC in Subjects With ALSNo drug interventionstreatment2active_not_recruiting
NCT02478450
Study to Investigate the Safety of the Transplantation (by Injection) of Human Glial Restricted Progenitor Cells (hGRPs; Q-Cells®) Into Subjects With Amyotrophic Lateral Sclerosis (ALS)treatment1 / 2not_yet_recruiting
NCT05959850
A Double-blind Randomised, Placebo-controlled Clinical Trial to Test Ambroxol Treatment in ALStreatment2recruiting
NCT01259050
Safety Study of High Doses of Zinc in ALS Patientstreatment1 / 2completed
NCT06201650
Neurofilament Light Chain in Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availablerecruiting
NCT04165850
Open Label Study to Evaluate Ciprofloxacin/Celecoxib Combination in Patients With ALStreatment2completed
NCT05595850
A Mindful Community for People With ALS and Their Primary CaregiversNo drug interventionssupportive_careNot Availablerecruiting
NCT04961450
Explore Biomarkers of Motor Neuron Disease/Frontal Dementia Spectrum Disease in ChinaNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT00982150
Extension Study of Talampanel for Amyotrophic Lateral Sclerosis (ALS)treatment2terminated
NCT03367650
Epidemiology and Genetics of the Amyotrophic Lateral Sclerosis in the French West IndiesNo drug interventionsdiagnosticNot Availableunknown_status
NCT04615923
HEALEY ALS Platform Trial - Regimen D Pridopidinetreatment2 / 3completed
NCT00047723
Minocycline to Treat Amyotrophic Lateral Sclerosistreatment3completed
NCT05035823
COMMAND Early Feasibility Study: Implantable BCI to Control a Digital Device for People With ParalysisNo drug interventionsdevice_feasibilityNot Availableactive_not_recruiting
NCT00397423
G-CSF Treatment for Amyotrophic Lateral Sclerosis: A RCT Study Assessing Clinical Responsetreatment2completed
NCT04840823
Enoxacin for Amyotrophic Lateral Sclerosis (ALS)treatment1 / 2completed
NCT04952038
Sleep Disorders and the Onset and Progression of ALSNo drug interventionsNot AvailableNot Availableunknown_status
NCT06021938
Alleviating Persistent Dyspnea in Amyotrophic Lateral Sclerosis Patients Treated With Non-Invasive Ventilation Through Immersive Virtual RealityNo drug interventionssupportive_careNot Availablerecruiting
NCT03359538
Rapamycin Treatment for ALStreatment2completed
NCT01889043
Monitoring of Non-invasive Ventilation During Sleep in ALSNo drug interventionsNot AvailableNot Availablecompleted
NCT06147843
French-German Cohort Study to Determine Factors Associated With Weight Loss in Amyotrophic Lateral SclerosisNo drug interventionsotherNot Availablenot_yet_recruiting
NCT05202743
Online Self-Compassion Course for pALS (Compassion pALS)No drug interventionsNot AvailableNot Availablecompleted
NCT01995903
Developing a Discrimination Model to Diagnose ALSNo drug interventionsdiagnosticNot Availablecompleted
NCT00718003
Noninvasive Examination of the Work of Breathing in Patients With Amyotrophic Lateral Sclerosis (ALS).No drug interventionsNot AvailableNot Availableterminated
NCT06266403
Evaluating Verbal Communication in Structured Interactions: Theoretical and Clinical ImplicationsNo drug interventionsbasic_scienceNot Availablenot_yet_recruiting
NCT01999803
A Safety Study of sNN0029 Administration Via Intracerebroventricular Route to Patients With ALStreatment1terminated
NCT04719403
Determining Feasibility and Acceptability of Sharing Video Recordings With Patients With ALS and CaregiversNo drug interventionshealth_services_researchNot Availablecompleted
NCT03268603
Intrathecal Autologous Adipose-derived Mesenchymal Stromal Cells for Amyotrophic Lateral Sclerosis (ALS)treatment2active_not_recruiting
NCT00125203
Study of Myobloc in the Treatment of Sialorrhea (Drooling) in Patients With Amyotrophic Lateral Sclerosis (ALS)treatment2 / 3completed
NCT02306590
Efficacy, Safety and Tolerability of High Lipid and Calorie Supplementation in Amyotrophic Lateral SclerosisNo drug interventionstreatmentNot Availablecompleted
NCT03705390
A Safety and Tolerability Study of ILB in Patients With Amyothrophic Lateral Sclerosis (ALS)treatment2completed
NCT03505021
Effects of Oral Levosimendan (ODM-109) on Respiratory Function in Patients With ALStreatment3completed
NCT03766321
Fecal Microbiota Transplantation Effect on Amyotrophic Lateral Sclerosis PatientstreatmentNot Availableactive_not_recruiting
NCT01933321
Effect of Intrathecal Administration of Hematopoietic Stem Cells in Patients With Amyotrophic Lateral Sclerosis (ALS)No drug interventionstreatment2 / 3completed
NCT05695521
Regulatory T Cells for Amyotrophic Lateral SclerosisNo drug interventionstreatment1recruiting
NCT06172621
Spinal Cord Associative Plasticity for ALSNo drug interventionsotherNot Availablerecruiting
NCT02104921
Innovative Ultrasound Technology in Neuromuscular DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT03876002
Evaluation of Microglial Activation in ALS With [18F]PBR06 (Peripheral Benzodiazepine Receptor-06) PETNo drug interventionsother1completed
NCT01772602
The National Amyotrophic Lateral Sclerosis RegistryNo drug interventionsNot AvailableNot Availablerecruiting
NCT02313402
A New Eye-based Communication Device for ALS PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT05237284
Phase 2 Study for SAR443820 in Participants With Amyotrophic Lateral Sclerosis (ALS)No drug interventionstreatment2terminated
NCT03764384
Validation Of Tidal/End -Tidal CO2 in ALSNo drug interventionsNot AvailableNot Availableunknown_status
NCT01759784
Intraventricular Transplantation of Mesenchymal Stem Cell in Patients With ALSNo drug interventionstreatment1withdrawn
NCT04821479
Repeated Mesenchymal Stem Cell Injections in ALSNo drug interventionstreatment1 / 2completed
NCT02460679
Safety and Biomarker Study of EPI-589 in Participants With Amyotrophic Lateral Sclerosis (ALS)treatment2completed
NCT06280079
Ultra-high-caloric, Fatty Diet in ALSNo drug interventionstreatmentNot Availablenot_yet_recruiting
NCT00560287
Non-Invasive Ventilation in Amyotrophic Lateral SclerosisNo drug interventionssupportive_care4unknown_status
NCT05119387
Genetic Study of Amyotrophic Lateral Sclerosis in NorwayNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT03321487
Blood-Brain Barrier Opening Using MR-Guided Focused Ultrasound in Patients With Amyotrophic Lateral SclerosisNo drug interventionstreatmentNot Availableunknown_status
NCT04051333
The E-health Application To Modify ORal Energy Intake and Measure Outcomes REmotely in ALS Clinical Trial (EAT MORE2)No drug interventionsNot AvailableNot Availablecompleted
NCT00801333
Derivation of Induced Pluripotent Stem Cells From an Existing Collection of Human Somatic CellsNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT02880033
Oxidative Stress and Apoptosis of Energy Metabolism by Deferiprone From the Circulating Lymphocytesbasic_scienceNot Availablecompleted
NCT00324454
Levetiracetam for Cramps, Spasticity and Neuroprotection in Motor Neuron Diseasetreatment2completed
NCT02383654
Compassionate Treatment : An Exploratory Clinical Trial to Assess Treatment of Amyotrophic Lateral SclerosisNo drug interventionstreatment1completed
NCT04997954
EMERALD TRIAL Open Label Extension StudyNo drug interventionstreatment4active_not_recruiting
NCT06566651
Emotion Processing Among Patients With ALSNo drug interventionsNot AvailableNot Availablerecruiting
NCT00860951
P300 Brain Computer Interface Keyboard to Operate Assistive TechnologyNo drug interventionshealth_services_research1 / 2completed
NCT00377351
Confirmation of Self-Reported Incident ALS Cases in the AARP-Diet and Health (AARP-DH) CohortNo drug interventionsNot AvailableNot Availablecompleted
NCT05033951
Optimizing INITIation of Non-invasive Ventilation in ALS PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT01825551
The Effect of GCSF in the Treatment of ALS Patientstreatment2 / 3completed
NCT04918251
EEG and TMS-based Biomarkers of ALS, MS and FTDNo drug interventionsNot AvailableNot Availableunknown_status
NCT00812851
Randomized Placebo-Controlled Crossover Trial With THC (Delta 9-Tetrahydrocannabinol) for the Treatment of Cramps in Amyotrophic Lateral Sclerosis (ALS)treatmentNot Availablecompleted
NCT03508453
IC14 for Treatment of Amyotrophic Lateral SclerosisNo drug interventionstreatment2withdrawn
NCT02942953
Diaphragmatic Pacer Placement: Anesthetic Management (DP)No drug interventionsNot AvailableNot Availablecompleted
NCT00847847
Neuromuscular Transmission in Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availablecompleted
NCT03900247
Restore Motor Function Through Robotic Arm Exoskeleton and Brain Computer InterfaceNo drug interventionssupportive_careNot Availableunknown_status
NCT04950647
Efficacy and Safety of Nitrazine in the Treatment of ALStreatment2unknown_status
NCT00925847
Effect of Lithium Carbonate in Patients With Amyotrophic Lateral Sclerosistreatment2completed
NCT00718445
Pennsylvania Consortium: Clinical DatabaseNo drug interventionsNot AvailableNot Availableterminated
NCT02327845
Phenotype, Genotype & Biomarkers in ALS and Related DisordersNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT04414345
HEALEY ALS Platform Trial - Regimen C CNM-Au8treatment2 / 3completed
NCT03868345
Speech Analysis in ALS PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT06318598
Biomarker-driven Phenotypic Dissection of Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availablerecruiting
NCT00620698
Electrical Impedance Myography as an Outcome Measure in Amyotrophic Lateral Sclerosis Clinical TrialsNo drug interventionsNot AvailableNot Availablecompleted
NCT03160898
A Study to Evaluate Efficacy, Safety and Tolerability of CK-2127107 in Patients With Amyotrophic Lateral Sclerosis (ALS)treatment2completed
NCT00714805
Non-Invasive Measurement of Gastrointestinal (GI) Motility in Patients With Amyotrophic Lateral Sclerosis (ALS)No drug interventionsNot AvailableNot Availablecompleted
NCT06094205
Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Speech-02)No drug interventionsotherNot Availablerecruiting
NCT03020797
A Clinical Trial to Evaluate the Safety and Efficacy of Fycompa in Subjects With Amyotrophic Lateral Sclerosis (ALS)treatmentNot Availableterminated
NCT03016897
ALS Testing Through Home-based Outcome MeasuresNo drug interventionsNot AvailableNot Availablecompleted
NCT00718497
Comparing The Cyberlink Control System to the Manual Letter Board for Communication Purposes in the ALS Patient PopulationNo drug interventionsNot AvailableNot Availablecompleted
NCT00298597
Influence of G-CSF and EPO on Associative Learning and Motor Skillstreatment2completed
NCT00965497
Escitalopram (Lexapro) for Depression MS or ALStreatment3completed
NCT01759797
Intravenous Transplantation of Mesenchymal Stem Cell in Patients With ALSNo drug interventionstreatment1completed
NCT01609283
A Dose-escalation Safety Trial for Intrathecal Autologous Mesenchymal Stem Cell Therapy in Amyotrophic Lateral SclerosisNo drug interventionstreatment1completed
NCT04326283
Trial of Safety, Tolerability and Efficacy of Trametinib (SNR1611) in Patients With Amyotrophic Lateral Sclerosis (ALS)treatment1 / 2terminated
NCT03560661
Acoustic and Perceptual Markers of Dysarthria in Amyotrophic Lateral Sclerosis (ALS)No drug interventionsNot AvailableNot Availablecompleted
NCT03840928
PatientSpot Formerly Known as ArthritisPowerNo drug interventionsNot AvailableNot Availablerecruiting
NCT05742828
Virtual Seating Coach on Power Wheelchairs of Persons With Amyotrophic Lateral Sclerosis (ALS)No drug interventionssupportive_careNot Availablecompleted
NCT05151211
Use of 1 Minute Sit to Stand Test for Physical Capacity and Effort Related Desaturation in Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT03168711
Safety of Urate Elevation in Amyotrophic Lateral Sclerosis (ALS)treatment2completed
NCT04691011
New Magnetic Resonance Imaging Biomarkers in Amyotrophic Lateral SclerosisNo drug interventionsdiagnosticNot Availablerecruiting
NCT00879593
Nocturnal PtcCO2 Monitoring in Patients With Amyotrophic Lateral Sclerosis (ALS)No drug interventionspreventionNot Availablecompleted
NCT00580593
Trial of Early Noninvasive Ventilation for Amyotrophic Lateral Sclerosis (ALS)No drug interventionstreatment1completed
NCT00070993
Creatine for the Treatment of Amyotrophic Lateral SclerosisNo drug interventionstreatment2completed
NCT03986671
Transmembrane Electromyography (TM-EMG) for the Assessment of Neuromuscular Function in the OropharynxNo drug interventionsdiagnosticNot Availablecompleted
NCT03613571
A Study to Evaluate the Safety, Tolerability and Efficacy of ILB in Patients With Amyotrophic Lateral SclerosisNo drug interventionstreatment2terminated
NCT05095571
A Trial of Nicotinamide/Pterostilbene Supplement in ALS: The NO-ALS Extension StudyNo drug interventionstreatmentNot Availablerecruiting
NCT05470478
iBCI Optimization for Veterans With ParalysisNo drug interventionsotherNot Availablenot_yet_recruiting
NCT02852278
A Patient Centric Motor Neuron Disease Activities of Daily Living ScaleNo drug interventionsNot AvailableNot Availablecompleted
NCT05423678
Clinical Trial - Analyzing Participation Experiences Of Amyotrophic Lateral Sclerosis PatientsNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT01583088
Early Stage Amyotrophic Lateral Sclerosis Phrenic StimulationNo drug interventionstreatment3terminated
NCT00956488
Supported Treadmill Ambulation Training (STAT) for Patients Diagnosed With Amyotrophic Lateral AclerosisNo drug interventionsprevention1 / 2completed
NCT03835507
Randomized, Double-blind, Safety and Efficacy of Recombinant Human Erythropoietin in Amyotrophic Lateral Sclerosisother1 / 2recruiting
NCT02588807
Food Supplement for the Treatment of Patients With Amyotrophic Lateral SclerosisNo drug interventionstreatment1withdrawn
NCT02306109
Effect of Motor Rehabilitation Treatment on Amyotrophic Lateral Sclerosis (ALS)No drug interventionstreatmentNot Availablecompleted
NCT00072709
Study Evaluating TCH346 and Placebo Administered Once Daily in Patients With Amyotrophic Lateral Sclerosis (ALS)treatment2completed
NCT04245709
Clenbuterol on Motor Function in Individuals With Amyotrophic Lateral Sclerosistreatment2completed
NCT03136809
ALS Treatment Extension Studytreatment1 / 2unknown_status
NCT04288856
Study to Assess the Safety, Tolerability, Pharmacokinetics, and Effect on Disease Progression of BIIB078 Administered to Previously Treated Adults C9ORF72-Associated Amyotrophic Lateral Sclerosis (ALS)No drug interventionstreatment1terminated
NCT05136885
HEALEY ALS Platform Trial - Regimen E SLS-005 - TrehaloseNo drug interventionstreatment2 / 3completed
NCT00035815
Insulin-like Growth Factor-1 in Amyotrophic Lateral Sclerosis (ALS) TrialNo drug interventionstreatment3completed
NCT05747937
Longitudinal Assessment of Autonomic and Sensory Nervous System in ALSNo drug interventionsbasic_scienceNot Availablerecruiting
NCT00563537
Molecular Imaging Modality by Positron Emission Tomography Using 18F-X : Study of Microglial Activation in Amyotrophic Lateral SclerosisNo drug interventionsdiagnostic1unknown_status
NCT03076632
Interactions Between Neurostimulation and Physical ExerciseNo drug interventionsdevice_feasibilityNot Availablewithdrawn
NCT03090932
Longitudinal Study of Innate Lymphoid Cells in Peripheral Blood in ALSNo drug interventionsNot AvailableNot Availableterminated
NCT02058732
Therapeutic Imaging Biomarkers for Amyotrophic Lateral SclerosisNo drug interventionsotherNot Availableterminated
NCT02450552
Clinical Trial of Ezogabine (Retigabine) in ALS Subjectstreatment2completed
NCT05753852
Open Label Extension of TUDCA-ALS Studytreatment3recruiting
NCT02447952
Exploratory Study of Biotelemetry in Amyotrophic Lateral SclerosisNo drug interventionsotherNot Availablecompleted
NCT01123200
An In-home Study of Brain Computer InterfacesNo drug interventionssupportive_careNot Availablecompleted
NCT03489200
EH301 for the Treatment of ALSNo drug interventionstreatmentNot Availablecompleted
NCT03204500
Dual Treatment With Lithium and Valproate in ALS.No drug interventionstreatment2completed
NCT02059759
Immuno-modulation in Amyotrophic Lateral Sclerosis- a Phase II Study of Safety and Activity of Low Dose Interleukin-2treatment2completed
NCT06219759
Reinnervation and Neuromuscular Transmission in ALSNo drug interventionsNot AvailableNot Availablerecruiting
NCT05725759
Rehabilitation in SOD1 ALS Treated With TofersenNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT03679975
Riluzole Oral Soluble Film (ROSF) Swallowing Safety in Amyotrophic Lateral Sclerosis (ALS)other2terminated
NCT03683875
Ultrasonography of the Neuromuscular Degeneration Behavior in Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availablecompleted
NCT04428775
A Safety and Biomarker Study of ALZT-OP1a in Subjects With Mild-Moderate ALS Diseasebasic_science2terminated
NCT00023075
Nuclear Magnetic Spectroscopy Imaging to Evaluate Primary Lateral Sclerosis, Hereditary Spastic Paraplegia and Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availablecompleted
NCT00107770
Safety Study of Oral Sodium Phenylbutyrate in Subjects With ALS (Amyotrophic Lateral Sclerosis)treatment1 / 2completed
NCT04455542
Peripheral Neurofilament Levels and Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availablecompleted
NCT02872142
Efficacy and Safety of Plasma Exchange With Albutein® 5% in Participants With Amyotrophic Lateral Sclerosistreatment2completed
NCT01091142
Single-Ascending-Dose Safety/Tolerability of NP001 in Amyotrophic Lateral Sclerosis (ALS)No drug interventionstreatment1completed
NCT05039099
A Study to Evaluate, Safety, Tolerability, Pharmacodynamic (PD) Markers and Pharmacokinetics (PK) of AP-101 in Participants With Amyotrophic Lateral Sclerosis (ALS)treatment2active_not_recruiting
NCT06046599
Remote Home Assessment of Patients With Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availablerecruiting
NCT02374606
Accurate Test of Limb Isometric Strength (ATLIS) in ALSNo drug interventionsNot AvailableNot Availableunknown_status
NCT06203106
NYSCF Scientific Discovery BiobankNo drug interventionsNot AvailableNot Availablerecruiting
NCT03664206
Assessing Motor Neuron Disease Mechanisms by Threshold Tracking Transcranial Magnetic Stimulation and Magnetic Resonance SpectroscopyNo drug interventionsNot AvailableNot Availablewithdrawn
NCT04875949
Anti-Cholinergic Receptors Antibodies, Autonomic Profile and Dysautonomia Symptoms in PAF, ALS and POTS (DISAUT-AB)No drug interventionssupportive_careNot Availablecompleted
NCT03651349
To Determine the Maximum Tolerated Dose (MTD) of HK-001 in Healthy VolunteersNo drug interventionstreatment1active_not_recruiting
NCT01709149
Study of Safety, Tolerability & Efficacy of CK-2017357 in Amyotrophic Lateral Sclerosis (ALS)treatment2completed
NCT05107349
Cell Signaling, Reinnervation and Metabolism in Kennedy Disease and Amyotrophic Lateral Sclerosis (ALS)No drug interventionsotherNot Availablerecruiting
NCT01486849
Dose Titration Study to Test Safety and Effects of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS)treatment2completed
NCT02269436
A follow-on Study to Assess Long-term Safety and Tolerability of i.c.v Administration of sNN0029 in Patients With ALStreatment1terminated
NCT05021536
Phase III Trial of AMX0035 for Amyotrophic Lateral Sclerosis TreatmentNo drug interventionstreatment3active_not_recruiting
NCT04140136
The Efficacy and Safety of Vitamin E Mixed Tocotrienols In Patients With Amyotrophic Lateral Sclerosis (ALS)No drug interventionstreatment2unknown_status
NCT03981536
A Study to Evaluate AP-101 in Familial and Sporadic Amyotrophic Lateral Sclerosis (ALS)basic_science1unknown_status
NCT00714636
Cerebrospinal Fluid RepositoryNo drug interventionsNot AvailableNot Availablecompleted
NCT02567136
Imaging Biomarkers in ALSNo drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT05597436
Intermediate-Sized Expanded Access StudyNot AvailableNot Availableno_longer_available
NCT05740813
HEALEY ALS Platform Trial - Regimen F ABBV-CLS-7262treatment2 / 3enrolling_by_invitation
NCT02507713
Quantitative Neuromuscular Ultrasonography in Amyotrophic Lateral Sclerosis (ALS)No drug interventionsNot AvailableNot Availablecompleted
NCT01650818
Aerobic Exercise Training in Amyotrophic Lateral SclerosisNo drug interventionssupportive_careNot Availableunknown_status
NCT03452618
Predictive Factors for the Diagnosis of Early Noninvasive Ventilation EquipmentNo drug interventionsdiagnosticNot Availableunknown_status
NCT01897818
Communication by Brain - Computer Interface in Amyotrophic Lateral Sclerosis:Feasibility StudyNo drug interventionssupportive_careNot Availableunknown_status
NCT04681118
Expanded Access Protocol: Repeated Administration of Nurown® (Autologous MSC-NTF Cells) for the Treatment of ALSNot AvailableNot Availableno_longer_available
NCT01935518
A Clinical Trial of Safety and Efficacy of Fasudil in Subjects With Amyotrophic Lateral Sclerosis (ALS)treatment2unknown_status
NCT05852418
Registry Study of Assistive Devices, Medicines and Healthcare Measures in ALS, SMA and Other Neurological Diseases.No drug interventionsNot AvailableNot Availablerecruiting
NCT04939818
Clinical Feasibility of Speech Phenotyping for Remote Assessment of Neurodegenerative and Psychiatric DisordersNo drug interventionsNot AvailableNot Availablecompleted
NCT01879241
Study of Rasagiline in Patients With Amyotrophic Lateral Sclerosistreatment2completed
NCT05842941
HEALEY ALS Platform Trial - Regimen G DNL343treatment2 / 3enrolling_by_invitation
NCT03202017
Lung Volume Recruitment Combined With Expiratory Muscle Strength Training in ALSNo drug interventionssupportive_careNot Availablecompleted
NCT05204017
Comprehensive Analysis Platform To Understand, Remedy and Eliminate ALSNo drug interventionsNot AvailableNot Availablerecruiting
NCT03806634
Development and Needs Assessment and Efficiency of Smart Communication System for Patients With ALS (Part 2)No drug interventionsNot AvailableNot Availableunknown_status
NCT02870634
Phase 1 Dose Escalation and PK Study of Cu(II)ATSM in ALS/MNDtreatment1completed
NCT06069934
Pridopidine in Amyotrophic Lateral Sclerosis (EAP 2)Not AvailableNot Availableavailable
NCT05764434
ALS Spinal Cord Gray and White Matter StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT02116634
Mesenchymal Stem Cell Injection in Amyotrophic Lateral SclerosisNo drug interventionstreatment1 / 2withdrawn
NCT00809224
Cortex Changes in Real/Imagined Movements in Amyotrophic Lateral Sclerosis (ALS)No drug interventionsNot AvailableNot Availablecompleted
NCT05928416
ALS Diagnosis From a Saliva Sample: a Non-coding RNA Analysis ApproachNo drug interventionsNot AvailableNot Availablerecruiting
NCT00317616
The Pre-symptomatic Familial Amyotrophic Lateral Sclerosis (Pre-fALS) StudyNo drug interventionsNot AvailableNot Availablerecruiting
NCT00718016
Assessment of the Cyberlink Control System for Use by the Amyotrophic Lateral Sclerosis (ALS) PatientNo drug interventionsNot AvailableNot Availableterminated
NCT03217396
Biomarkers of Synaptic Damage in Multiple SclerosisNo drug interventionsNot AvailableNot Availablerecruiting
NCT06169696
EMPOWER Early Feasibility Study: Non-invasive BCI to Control a Wheelchair for People With ParalysisNo drug interventionsdevice_feasibilityNot Availablenot_yet_recruiting
NCT05299658
An Open-Label Extension for the Phase 2 Study in Early Symptomatic Amyotrophic Lateral Sclerosis Patients on Stable Background Therapy to Assess Bioenergetic Catalysis With CNM-Au8 to Slow Disease Progression in ALSNo drug interventionstreatment2active_not_recruiting
NCT01906658
A Study to Explore the Safety and Tolerability of Acthar in Patients With Amyotrophic Lateral Sclerosistreatment2completed
NCT00116558
Early Treatment of Amyotrophic Lateral Sclerosis (ALS) With Nutrition and Non-Invasive Positive Pressure VentilationNo drug interventionssupportive_careNot Availablecompleted
NCT00718458
EEG-Based Brain-Computer Interface Project for Individuals With Amyotrophic Lateral Sclerosis (ALS)No drug interventionsNot AvailableNot Availablecompleted
NCT01569958
Transcranial Direct Current Stimulation as a Novel Therapeutic Approach in Amyotrophic Lateral SclerosisNo drug interventionstreatment2unknown_status
NCT03362658
Novel MRI Biomarkers for Monitoring Disease Progression in ALSNo drug interventionsNot AvailableNot Availablerecruiting
NCT05053035
A Phase 2 Study to Evaluate AL001 in C9orf72-Associated ALStreatment2terminated
NCT03487263
Dose-Escalation, Safety and Pharmacokinetic Study of IC14 in Motor Neurone DiseaseNo drug interventionstreatment1completed
NCT01160263
Study of Dopamine and Serotonin Transporters in Patients With Amyotrophic Lateral Sclerosis and Controlsdiagnostic3completed
NCT02548663
Sport Therapy and Osteopathy Manipulative Treatment in ALSNo drug interventionstreatmentNot Availablecompleted
NCT05880563
Investigation of Cannabinoid 2-receptor Expression in the Brain and Spine of ALS-patients Compared to Healthy Controls With PET (18F-RoSMALS)No drug interventionsbasic_science1not_yet_recruiting
NCT02665663
Tongue Strength in Amyotrophic Lateral Sclerosis (ALS)No drug interventionsscreeningNot Availableunknown_status
NCT02290886
A Multicenter Phase I/II Clinical Trial to Evaluate Safety of Mesenchymal Stem Cell in Patients With Amyotrophic Sclerosis LateralNo drug interventionstreatment1 / 2completed
NCT01254539
Clinical Trial on The Use of Autologous Bone Marrow Stem Cells in Amyotrophic Lateral Sclerosis (Extension CMN/ELA)No drug interventionstreatment1 / 2completed
NCT04305639
The Reliability and Validity of Turkish Version of ''The Dyspnea-ALS-Scale (DALS-15)"No drug interventionsNot AvailableNot Availablecompleted
NCT02315339
European Home Mechanical Ventilation RegistryNo drug interventionsNot AvailableNot Availableterminated
NCT03326622
Exercise and Disease Progression in Amyotrophic Lateral Sclerosis PatientsNo drug interventionssupportive_careNot Availablecompleted
NCT04240925
Tolerability, Safety and Efficacy of Sigh Breaths During NIMV in Motor Neuron DiseaseNo drug interventionssupportive_careNot Availableunknown_status
NCT04632225
Safety of Engensis in Participants With Amyotrophic Lateral Sclerosistreatment2completed
NCT06426030
Validation of Czech Language Versions of Questionnaires for ALS Patients' Functional Status and Biomarker Long-term Follow-upNo drug interventionsNot AvailableNot Availablerecruiting
NCT05829330
Ambulatory Versus Inpatient Initiation of Home Mechanical VentilationNo drug interventionstreatmentNot Availablerecruiting
NCT03113630
Virtual Task in Amyotrophic Lateral SclerosisNo drug interventionstreatmentNot Availablecompleted
NCT02682030
The Use of Airway Clearance Devices in ALSNo drug interventionstreatmentNot Availablecompleted
NCT02869048
Amyotrophic Lateral Sclerosis and the Innate Immune SystemNo drug interventionsNot AvailableNot Availablerecruiting
NCT03481348
Pharyngeal Electrical Stimulation in Amyotrophic Lateral SclerosisNo drug interventionstreatment1 / 2completed
NCT00958048
Effects of Nocturnal Non-invasive Ventilation in Patients With Amyotrophic Lateral SclerosisNo drug interventionstreatmentNot Availablecompleted
NCT03067857
Autologous Bone Marrow-Derived Stem Cell Therapy for Motor Neuron DiseaseNo drug interventionstreatment1 / 2unknown_status
NCT00004457
Determinants of Disease Severity in Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availableunknown_status
NCT02238626
Ibudilast (MN-166) in Subjects With Amyotrophic Lateral Sclerosis (ALS)treatment2completed
NCT06392126
Personalized Antisense Oligonucleotide Therapy for A Single Participant With CHCHD10 ALSNo drug interventionstreatment1 / 2active_not_recruiting
NCT05866926
Study to Investigate the Long-term Safety of FAB122 in Patients With Amyotrophic Lateral SclerosisNo drug interventionstreatment3terminated
NCT02670226
Muscular Biomarkers in Amyotrophic Lateral SclerosisNo drug interventionshealth_services_researchNot Availablecompleted
NCT01378026
Study of the Role of G72 in Amyotrophic Lateral Sclerosis: Biomarker Discovery and Mechanism InvestigationNo drug interventionsNot AvailableNot Availableunknown_status
NCT03618966
Neuromuscular Magnetic Stimulation in ALS PatientsNo drug interventionstreatment2completed
NCT00005766
Clinical Trial of Creatine in Amyotrophic Lateral Sclerosistreatment2completed
NCT04579666
MERIDIAN: A Study to Evaluate the Efficacy and Safety of Pegcetacoplan in Adults With Amyotrophic Lateral Sclerosis (ALS)treatment2terminated
NCT00353665
Memantine for Disability in Amyotrophic Lateral Sclerosis (MEDALS)treatment2 / 3completed
NCT06325865
Perception of Unpleasant Sensations During Study Procedures in ALS PatientsNo drug interventionsNot AvailableNot Availablerecruiting
NCT04248465
An Efficacy and Safety Study of Ravulizumab in ALS Participantstreatment3terminated
NCT02236065
Combination Therapy of Cord Blood and G-CSF for Patients With Brain Injury or Neurodegenerative DisorderstreatmentNot Availablecompleted
NCT00230074
A Long-term Extension Study of TCH346 and Placebo Administered Once Daily in Patients With Amyotrophic Lateral Sclerosis(ALS)treatment2completed
NCT00005674
Clinical Trial of Creatine in Amyotrophic Lateral Sclerosis [ALS]treatment2completed
NCT01090674
Relationship Between Respiratory Functional Tests and Image Thoracic Techniques in Patients With Neuromuscular DiseasesNo drug interventionsNot AvailableNot Availablecompleted
NCT02611674
Methodology Study of Novel Outcome Measures to Assess Progression of ALSNo drug interventionsNot AvailableNot Availablecompleted
NCT00833820
Repetitive Transcranial Magnetic Stimulation (rTMS) in Amyotrophic Lateral SclerosisNo drug interventionstreatment2 / 3completed
NCT00714220
Quantitative Measurement of Nutritional Substrate Utilization in Patients With Amyotrophic Lateral Sclerosis (ALS)No drug interventionsNot AvailableNot Availableterminated
NCT03456882
The Effect of RNS60 on ALS BiomarkersNo drug interventionsother2completed
NCT02405182
MRI Biomarkers in ALSNo drug interventionsNot AvailableNot Availablecompleted
NCT02750982
Laughter Therapy Effects on Mood, Stress and Self-efficacy in People With Neurological Diseases.No drug interventionshealth_services_researchNot Availablecompleted
NCT05358431
Stratification of Presymptomatic Amyotrophic Lateral Sclerosis: the Development of Novel Imaging BiomarkersNo drug interventionsotherNot Availablerecruiting
NCT01281631
A Study of NP001 in Subjects With Amyotrophic Lateral Sclerosis (ALS)No drug interventionstreatment2completed
NCT01020331
Memantine Therapy in Amyotrophic Lateral Sclerosistreatment2completed
NCT05819931
Breathing With Amyotrophic Lateral SclerosisNo drug interventionstreatmentNot Availablerecruiting
NCT00716131
Amyotrophic Lateral Sclerosis (ALS) Tissue Donation ProgramNo drug interventionsNot AvailableNot Availablecompleted
NCT06541873
Gait Patterns in Dual-task Conditions in Patients With Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT05724173
Feasibility of the BrainGate2 Neural Interface System in Persons With TetraplegiaNo drug interventionsotherNot Availablerecruiting
NCT04816227
Expression Profile Study of Macrophages From Patients Affected by ALS or Other Related Motor ImpairmentsNo drug interventionsNot AvailableNot Availablerecruiting
NCT00355576
Combination Therapy Selection Trial in Amyotrophic Lateral Sclerosistreatment2completed
NCT05542576
AMDX-2011P Retinal Tracer in Subjects With Neurodegenerative Diseases Associated With Amyloidogenic ProteinopathyNo drug interventionsdiagnostic1 / 2recruiting
NCT00339976
Exposure to Neurotoxins as Risk Factors for Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availablecompleted
NCT01424176
Dexpramipexole Renal PK Studybasic_science1completed
NCT02881476
Therapeutic Treatment of Amyotrophic Lateral SclerosisNo drug interventionstreatment1unknown_status
NCT01753076
Study of Ozanezumab (GSK1223249) Versus Placebo in the Treatment of Amyotrophic Lateral Sclerosistreatment2completed
NCT04257760
Evaluation of Palliative Care for Patients With ALS and Their CaregiversNo drug interventionstreatmentNot Availablecompleted
NCT06396260
Structural and Functional Networks in ALS: An Insight Into Pseudobulbar AffectNo drug interventionsotherNot Availablenot_yet_recruiting
NCT00635960
Growth Hormone in Amyotrophic Lateral Sclerosistreatment2completed
NCT05562960
Plasmapheresis in Amyotrophic Lateral Sclerosis With Autoantibody Against NRIPNo drug interventionstreatmentNot Availablerecruiting
NCT03516994
Reducing Disparities in the Quality of Advance Care Planning for Older AdultsNo drug interventionsotherNot Availablecompleted
NCT01854294
GM604 Phase 2A Randomized Double-blind Placebo Controlled Pilot Trial in Amyotrophic Lateral Disease (ALS)treatment2completed
NCT06556394
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RAG-17 in Subjects With Amyotrophic Lateral Sclerosis (ALS) With Superoxide Dismutase Type 1 (SOD1) Gene Mutationtreatment1not_yet_recruiting
NCT06450691
Modeling Amyotrophic Lateral Sclerosis With FibroblastsNo drug interventionsotherNot Availablenot_yet_recruiting
NCT03706391
Study of ALS Reversals 4: LifeTime ExposuresNo drug interventionsNot AvailableNot Availablecompleted
NCT03491462
Arimoclomol in Amyotropic Lateral Sclerosistreatment3completed
NCT02710162
Accurate Screening Tools for Dysphagia in Amyotrophic Lateral Sclerosis (ALS)diagnostic0completed
NCT03519880
A Pilot Study of the Utility of 3D Printed Masks for ALS SubjectsNo drug interventionsdevice_feasibilityNot Availableterminated
NCT01511029
Study to Evaluate the QTC Interval in Healthy Volunteers Dosed With Dexpramipexole (QTC = Electrocardiogram (ECG) Interval Measured From the Onset of the QRS Complex to the End of the T Wave Corrected for Heart Rate)treatment1completed
NCT04008329
A Registered Cohort Study on Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availablerecruiting
NCT00818389
Study to Investigate the Safety and Efficacy of Lithium in Volunteers With Amyotrophic Lateral Sclerosis (ALS)treatment2 / 3terminated
NCT03095989
An Online Mindfulness Intervention for People With ALS and Their CaregiversNo drug interventionssupportive_careNot Availablecompleted
NCT04172792
Safety and Tolerability Ultra-high-caloric Food Supplements in Amyotrophic Lateral Sclerosis (ALS)No drug interventionstreatment1completed
NCT03382392
Hypermetabolism in ALS Using Six REE FormulasNo drug interventionsNot AvailableNot Availablecompleted
NCT02532244
Genetics of Pediatric-Onset Motor Neuron and Neuromuscular DiseasesNo drug interventionsNot AvailableNot Availablerecruiting
NCT02166944
Tamoxifen Treatment in Patients With Motor Neuron Diseasetreatment1 / 2completed
NCT00673140
Far Infrared Irradiation for Control, Management and Treatment of Amyotrophic Lateral Sclerosis (ALS)No drug interventionstreatment1unknown_status
NCT03186040
Open-label Clinical Trial of Lacosamide in ALStreatment1 / 2completed
NCT01771640
Intrathecal Transplantation of Mesenchymal Stem Cell in Patients With ALSNo drug interventionstreatment1completed
NCT04960540
Multimodal Brain Imaging StudyNo drug interventionsNot AvailableNot Availableunknown_status
NCT01551940
Toxin Treatment for Amyotrophic Lateral Sclerosis (ALS) Related Sialorrheatreatment2completed
NCT04454840
Treatment of Intravenous Infusion Plasma in Amyotrophic Lateral Sclerosistreatment0completed
NCT04518540
Explore Neuroprotective Effect of Lipoic Acid in Amyotrophic Lateral SclerosistreatmentNot Availableunknown_status
NCT01640067
Human Neural Stem Cell Transplantation in Amyotrophic Lateral Sclerosis (ALS)No drug interventionsNot Available1completed
NCT06249867
A Study to Assess the Safety, Tolerability, and Pharmacology of Darifenacin in Patients With ALStreatment2not_yet_recruiting
NCT05404867
Study of Structural and Functional Brain Connectivity Changes in ALS (CoALS-II)No drug interventionsotherNot Availablecompleted
NCT02496767
Ventilatory Investigation of Tirasemtiv and Assessment of Longitudinal Indices After Treatment for a Yeartreatment3completed
NCT05003167
Effectiveness of Expiratory Muscle Strength Training for Improving Communication in ALSNo drug interventionstreatmentNot Availablecompleted
NCT00748501
Clinical Trial of SB-509 in Subjects With Amyotrophic Lateral Sclerosis (ALS)treatment2completed
NCT03296501
Intraspinal Transplantation of Autologous ADRC in ALS PatientsNo drug interventionstreatment1unknown_status
NCT03811301
[BrainConnexion] - Neurodevice Phase I TrialNo drug interventionsotherNot Availableactive_not_recruiting
NCT06307301
Study in ALS With Abatacept & IL-2treatment1active_not_recruiting
NCT06228001
Holter of Movement in Patients With Amyotrophic Lateral Sclerosis.No drug interventionsNot AvailableNot Availablerecruiting
NCT02039401
Safety Study of VM202 to Treat Amyotrophic Lateral Sclerosistreatment1 / 2completed
NCT00800501
A Safety and Tolerability Study of Intracerebroventricular Administration of sNN0029 to Patients With Amyotrophic Lateral Sclerosistreatment1 / 2completed
NCT01363401
Safety and Efficacy Study of Autologous Bone Marrow Derived Stem Cell Treatment in Amyotrophic Lateral SclerosisNo drug interventionstreatment1 / 2completed
NCT01119001
A P300 Brain Computer Interface Keyboard to Control Assistive Technology For Use by People With Amyotrophic Lateral SclerosisNo drug interventionssupportive_careNot Availablecompleted
NCT04309604
IC14 for ALS Patients Expanded AccessNo drug interventionsNot AvailableNot Availableno_longer_available
NCT00160004
The Effect of Intensive Controlled Exercise in the Early Stages of Amyotrophic Lateral SclerosisNo drug interventionstreatment1 / 2terminated
NCT03285204
Relationship Between Neurological Disability and Visual Impairment in Patients With ALS or Friedreich's AtaxiaNo drug interventionsNot AvailableNot Availableunknown_status
NCT02011204
Study of Electrical Impedance Myography (EIM) in ALSNo drug interventionsNot AvailableNot Availablecompleted
NCT05039268
3K3A-APC for Treatment of Amyotrophic Lateral Sclerosis (ALS)No drug interventionstreatment2completed
NCT05218668
Rho Kinase Inhibitor in Amyotrophic Lateral Sclerosis (REAL)treatment2recruiting
NCT03377868
Optic Coherence Tomography in Patients With Amyotrophic Lateral SclerosisNo drug interventionsdiagnosticNot Availableunknown_status
NCT03793868
Perampanel Single Ascending Dose Transcranial Magnetic Stimulation Biomarker Study in Amyotrophic Lateral Sclerosisother0completed
NCT03293069
Conservative Iron Chelation as a Disease-modifying Strategy in Amyotrophic Lateral Sclerosistreatment2 / 3active_not_recruiting
NCT01777646
Autologous Mesenchymal Bone Marrow Stromal Cells Secreting Neurotrophic Factors (MSC-NTF), in Patients With Amyotrophic Lateral Sclerosis (ALS)No drug interventionstreatment2completed
NCT00537446
Effect of Noninvasive Ventilation on Lung Function in Amyotrophic Lateral SclerosisNo drug interventionssupportive_careNot Availableterminated
NCT05768646
Counterfactual Thinking in Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availablerecruiting
NCT03214146
Safety/Efficacy Study of 2nd Cycle Treatment After 6 Months of 1st Cycle HLA-haplo Matched Allogenic Bone Marrow Derived Stem Cell Treatment in ALSNo drug interventionstreatment1unknown_status
NCT02418546
Electronic-health Application To Measure Outcomes REmotely Clinical TrialNo drug interventionssupportive_careNot Availablecompleted
NCT00542412
CARE Canadian ALS Riluzole Evaluationtreatment4completed
NCT00331812
Mitochondrial Functions and Oxidative Stress in ALS PatientsNo drug interventionsNot AvailableNot Availableunknown_status
NCT00136110
Trial of Sodium Valproate in Amyotrophic Lateral Sclerosistreatment3completed
NCT02710110
Respiratory Strength Training in Persons With Amyotrophic Lateral Sclerosis (ALS)treatment0completed
NCT04436510
HEALEY ALS Platform Trial - Regimen B Verdiperstattreatment2 / 3completed
NCT04557410
Open Label Study: Treatment of ALS Fatigue With PolyMVANo drug interventionssupportive_care1completed
NCT05104710
Intermuscular Coherence as a Biomarker for ALSNo drug interventionsNot AvailableNot Availablerecruiting
NCT04953481
Home Care Needs and Current Nursing Status of Patients With Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availableunknown_status
NCT03883581
Impact of Nuedexta on Bulbar Physiology and Function in ALStreatment1 / 2completed
NCT01257581
Safety and Efficacy Study of Creatine and Tamoxifen in Volunteers With Amyotrophic Lateral Sclerosis (ALS)treatment2completed
NCT01565395
Incobotulinum Toxin A for Sialorrhea in Parkinson's Disease (PD)/Parkinsonism and Amyotrophic Lateral Sclerosis (ALS)treatment2withdrawn
NCT05830214
Digital Smartwatch Measurements as Potential Biomarkers for Remote Disease Tracking in ALSNo drug interventionsNot AvailableNot Availablewithdrawn
NCT03338114
Study to Evaluate the Safety & Efficacy of FLX-787-ODT to Treat Fasciculations in Tongue and Upper or Lower Extremity Muscles Most Affected in Subjects With ALSNo drug interventionstreatment1 / 2withdrawn
NCT03127514
AMX0035 in Patients With Amyotrophic Lateral Sclerosis (ALS)treatment2completed
NCT02851914
SSRIs vs. TCAs for Depression in ALS Patientstreatment0completed
NCT05041114
SWITCH II Early Feasibility Study: Implantable BCI to Control a Digital Device for People With ParalysisNo drug interventionstreatmentNot Availablewithdrawn
NCT05019014
Olfactory Deficits in Neurologic DiseaseNo drug interventionsNot AvailableNot Availablecompleted
NCT04858555
Staging System in Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availablerecruiting
NCT05279755
A Study to Evaluate the Safety and Pharmacokinetics of Single and Multiple Doses of Prosetin in Healthy Volunteerstreatment1unknown_status
NCT04993755
A Phase 2a Study of TPN-101 in Patients With C9ORF72 ALS/FTDNo drug interventionstreatment2active_not_recruiting
NCT02943850
CNS10-NPC-GDNF for the Treatment of ALSNo drug interventionstreatment1completed
NCT02962050
Delineating Swallowing Impairment and Decline in ALSNot AvailableNot Availablecompleted
NCT06315608
MRG-001 in Patients With Amyotrophic Lateral SclerosisNo drug interventionstreatment2not_yet_recruiting
NCT01874808
From Movement Preparation to Gait Execution in ALSNo drug interventionsNot AvailableNot Availablecompleted
NCT03975608
Psychological Therapy for Patients With ALSNo drug interventionssupportive_careNot Availablecompleted
NCT03984708
New Therapeutic Strategy in ALS Based on Metabolic Status and Associated Metabolic Pathways.No drug interventionshealth_services_researchNot Availableactive_not_recruiting
NCT05309408
A Longitudinal Analysis of Biomarkers in Patients With ALSNo drug interventionsNot AvailableNot Availablerecruiting
NCT03613038
A Systematic Investigation of Phonetic Complexity Effects on Articulatory Motor Performance in Progressive DysarthriaNo drug interventionsbasic_scienceNot Availablecompleted
NCT03887338
Systematic Laryngoscopic Evaluation of Upper Airways in Ventilated ALS Patients in Portugal and in NorwayNo drug interventionssupportive_careNot Availableunknown_status
NCT01530438
Study of Cognitive and Emotional Disorders in Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availableunknown_status
NCT05116943
Biospecimen Biorepository for the Study of ALS, ALS-FTD and Similar Neurodegenerative DisordersNo drug interventionsNot AvailableNot Availablerecruiting
NCT04390386
Controlled Study of IC14 for Treatment of ALSNo drug interventionstreatment2withdrawn
NCT04446325
Venous Disease Thromboembolic and Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availablecompleted
NCT06665165
AMX0114 in Adult Participants With Amyotrophic Lateral SclerosisNo drug interventionstreatment1not_yet_recruiting
NCT05602142
Study of [11C]CPPC as a Clinical PET Radioligand Biomarker of Microglial Activation in ALSNo drug interventionsdiagnostic1 / 2not_yet_recruiting
NCT05913882
Combined Respiratory Training in Persons with ALSNo drug interventionstreatmentNot Availablerecruiting
NCT06595212
Genetics and Environment INtersection in the ALS-FTD Spectrum: an Italian Twins Cohort StudY with a Multi-Omics ApproachNo drug interventionsNot AvailableNot Availablerecruiting
NCT04569084
Efficacy and Safety Study of Oral Edaravone Administered in Subjects With ALStreatment3terminated
NCT06377033
Using the EHR to Advance Genomic Medicine Across a Diverse Health SystemNo drug interventionshealth_services_researchNot Availablerecruiting
NCT03457753
Riluzole Oral Soluble Film Safety and Tolerability in Amyotrophic Lateral Sclerosisother2withdrawn
NCT01583205
Coping Effectiveness Training for ALSNo drug interventionstreatmentNot Availablewithdrawn
NCT02795897
Genomic Translation for Amyotrophic Lateral Sclerosis CareNo drug interventionsNot AvailableNot Availablecompleted
NCT04224961
Respiratory Muscle Training (RMT) in ALSNo drug interventionssupportive_careNot Availablecompleted
NCT05581771
Factors Associated With Success of NIPPV in ALS PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT05151471
Efficacy and Safety Extension Study of Oral Edaravone Administered in Subjects With ALStreatment3terminated
NCT02228915
Analysis of Post-Translational Modifications of a Critical Protein Implicated in Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availablecompleted
NCT05568615
Extension Study Following the Studies MT-1186-A03 or A04 to Evaluate the Safety of Oral Edaravone in Subjects With ALStreatment3completed
NCT03366506
Investigation of the Epidemiological Factors Associated With the Development of Amyotrophic Lateral Sclerosis (ALS)No drug interventionsNot AvailableNot Availablerecruiting
NCT06005506
National Multicenter Interventional Study Aimed at Evaluating the Effect on the Intestinal Microbiota in Chronically Frail Patients Who Share Alterations in Intestinal Function.No drug interventionssupportive_careNot Availablecompleted
NCT05621213
Satisfaction of Patients With Amyotrophic Lateral Sclerosis Regarding Home Assisted TeleconsultationNo drug interventionshealth_services_researchNot Availablerecruiting
NCT04054141
rTMS in Treatment of SpasticityNo drug interventionstreatmentNot Availableterminated
NCT06286917
Initiation of Noninvasive Ventilation in ALS Patients With Chronic Respiratory InsufficiencyNo drug interventionsbasic_scienceNot Availablerecruiting
NCT06511934
Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Tablet-01)No drug interventionsdevice_feasibilityNot Availablerecruiting
NCT03214224
Remote Pulmonary Function Testing in Amyotrophic Lateral Sclerosis (Pilot)No drug interventionshealth_services_researchNot Availablecompleted
NCT04165824
Safety Study of Oral Edaravone Administered in Subjects With ALStreatment3completed
NCT04490096
Multimodal Imaging Outcome Measures for ALS (Image ALS)No drug interventionsdiagnostic1terminated
NCT05287958
Feasibility of an Electrical Impedance Tomography Device for Pulmonary Function Testing in ALS PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT05271435
Digital Tools for Assessment of Motor Functions and Falls in ALSNo drug interventionsNot AvailableNot Availablerecruiting
NCT03506425
A Pilot Trial of Triheptanoin for People With Amyotrophic Lateral Sclerosis (PALS)treatment1 / 2completed
NCT01984957
Differential Study of Muscle TranscriptomeNo drug interventionsdiagnosticNot Availablecompleted
NCT05635266
Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research InitiativesNo drug interventionsNot AvailableNot Availablerecruiting
NCT02819765
Deep Phenotyping in Patients With ALSNo drug interventionsNot AvailableNot Availablecompleted
NCT03865420
Amyotrophic Lateral Sclerosis (ALS) Families ProjectNo drug interventionsNot AvailableNot Availablerecruiting
NCT05683860
Open-label Extension (OLE) Study of WVE-004 in Patients With C9orf72-associated Amyotrophic Lateral Sclerosis (ALS) and/or Frontotemporal Dementia (FTD)No drug interventionstreatment1 / 2terminated
NCT06215391
Customized Masks in Non-Invasive Mechanical VentilationNo drug interventionstreatmentNot Availablerecruiting
NCT02716662
Safety of Caprylic Triglycerides in ALS: A Pilot StudyNo drug interventionstreatmentNot Availablecompleted
NCT02429492
Spinal Interneuron Excitability in ALSNo drug interventionsbasic_scienceNot Availableunknown_status
NCT01124292
Evaluation of a Tongue Operated Assistive Technology for Individuals With Severe ParalysisNo drug interventionssupportive_care1completed
NCT01393444
ECoG Direct Brain Interface for Individuals With Upper Limb ParalysisNo drug interventionsNot AvailableNot Availablecompleted
NCT04270604
Biological Sample Collection for Research and BiobankingNo drug interventionsNot AvailableNot Availableterminated
NCT06453668
A Study of TCD601 (Siplizumab) in Newly Diagnosed Adult Amyotrophic Lateral Sclerosis (ALS) Patientsbasic_science1active_not_recruiting
NCT03373981
Non-invasive Brain Stimulation for the Treatment of Depression Symptoms in ALSNo drug interventionstreatmentNot Availableterminated
NCT01785550
Neuromuscular Ultrasound in ALSNo drug interventionsNot AvailableNot Availablecompleted
NCT00076154
National Registry of Veterans With Amyotrophic Lateral Sclerosis and DNA BankNo drug interventionsNot AvailableNot Availablecompleted
NCT05031351
NF-ÎşB Inhibition in Amyotrophic Lateral SclerosisNo drug interventionstreatment2unknown_status
NCT03886753
Pharmacokinetic (PK) and Pharmacodynamics (PD) Study of Ilera Specific ProductsNo drug interventionsNot AvailableNot Availableterminated
NCT01962311
Evaluation of Metabolomic Analysis in Early Diagnosis of ALSNo drug interventionsdiagnosticNot Availablecompleted
NCT04987671
Pharmacokinetic and Pharmacodynamic Study of AMX0035 in Patients With ALSNo drug interventionstreatment1 / 2active_not_recruiting
NCT02525471
A Pilot Study of RNS60 in Amyotrophic Lateral Sclerosis (ALS)No drug interventionstreatment1completed
NCT02495571
Assessment of Voluntary and Reflex Cough in Patients With ALSNo drug interventionsdiagnosticNot Availableunknown_status
NCT02457715
Feasibility of a Consumer Based Accelerometer in Monitoring Outpatient Physical Activity: A Study in Patients With Cancer and Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availablecompleted
NCT00696332
Talampanel for Amyotrophic Lateral Sclerosis (ALS)treatment2completed
NCT03698149
ECoG BMI for Motor and Speech ControlNo drug interventionsdevice_feasibilityNot Availablerecruiting
NCT03019419
Perampanel for Sporadic Amyotrophic Lateral Sclerosis (ALS)treatment2completed
NCT05377424
Adenosine 2A Receptor Antagonism and AIH in ALStreatment1 / 2recruiting
NCT04490148
Remote Pulmonary Function Testing and Nurse Coaching in ALSNo drug interventionshealth_services_researchNot Availablecompleted
NCT04396873
PET Imaging of Cyclooxygenases in Neurodegenerative Brain Diseasediagnostic1recruiting
NCT01035476
Optimizing NIPPV Use for Patients With ALSNo drug interventionssupportive_careNot Availablecompleted
NCT04931862
Study of WVE-004 in Patients With C9orf72-associated Amyotrophic Lateral Sclerosis (ALS) or Frontotemporal Dementia (FTD)No drug interventionstreatment1 / 2terminated
NCT04204889
Trial of Oxaloacetate in ALStreatment1completed
NCT00340301
Exposure to Neurotoxins as Risk Factors for ALSNo drug interventionsNot AvailableNot Availablecompleted
NCT02756104
T Cell Phenotypes in Amyotropic Lateral Sclerosis (ALS), Influence of Vitamin DNo drug interventionsdiagnosticNot Availablecompleted
NCT04138095
Virtual Reality as an Adjunct to Management of Pain and Anxiety in Palliative CareNo drug interventionstreatmentNot Availableunknown_status
NCT03472950
Safety and Efficacy of Ranolazine for the Treatment of Amyotrophic Lateral Sclerosistreatment2recruiting
NCT05966038
ALS/MND Natural History Study Data RepositoryNo drug interventionsNot AvailableNot Availablerecruiting
NCT06671236
Clinical Study of Regulatory T Cells (Tregs) in the Treatment of Neurodegenerative DiseasesNo drug interventionstreatment1recruiting
NCT06583395
Quest to Analyze One Thousand Humans MeditatingNo drug interventionsNot AvailableNot Availableenrolling_by_invitation
NCT06643481
A Clinical Trial to Learn About the Effects of VHB937 in People With Amyotrophic Lateral Sclerosis (ALS)No drug interventionstreatment2recruiting
NCT06645197
An IIT Clinical Study to Evaluate the Safety, Tolerability, and Preliminary Efficacy of a Single Intrathecal Injection of SNUG01 in Patients with Amyotrophic Lateral SclerosisNo drug interventionstreatment0not_yet_recruiting
NCT06608004
Influence of Olfacto-gustatory Sensoriality on the Nutritional Status of Patients with Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availablenot_yet_recruiting
NCT06351592
First in Human (FIH) Study of ALN-SOD in Adult Participants With Amyotrophic Lateral Sclerosis Associated With Mutation in the SOD1 Gene (SOD1-ALS)No drug interventionstreatment1recruiting
NCT01786603
Rasagiline in Subjects With Amyotrophic Lateral Sclerosis (ALS)treatment2completed
NCT01945853
Magnetic Resonance Imaging (MRI) in Amyotrophic Lateral Sclerosis (ALS)No drug interventionsdiagnosticNot Availablewithdrawn
NCT02588677
Masitinib in Combination With Riluzole for the Treatment of Patients Suffering From Amyotrophic Lateral Sclerosis (ALS)treatment2 / 3completed
NCT04055532
Biomarkers in Neurodegenerative DiseasesNo drug interventionsNot AvailableNot Availablewithdrawn
NCT02537132
"New Perspectives of Adaptation to NIV in ALS"No drug interventionstreatmentNot Availablecompleted
NCT01592552
A Biospecimen and Clinical Data Study on Patients for Drug & Biomarker DiscoveryNo drug interventionsNot AvailableNot Availablecompleted
NCT02469675
Brain and Nerve Stimulation for Hand Muscles in Spinal Cord Injury and ALSNo drug interventionsbasic_scienceNot Availablecompleted
NCT01776970
Safety and Efficacy on Spasticity Symptoms of a Cannabis Sativa Extract in Motor Neuron Diseasesupportive_care2 / 3completed
NCT01605006
Humanitarian Device Exemption Post-Approval Study of NeuRx Diaphragm Pacing System for Amyotrophic Lateral SclerosisNo drug interventionstreatmentNot Availablecompleted
NCT00420719
Motor-Point Stimulation for Conditioning the Diaphragm of Patients With Amyotrophic Lateral Sclerosis (ALS)No drug interventionstreatmentNot Availableunknown_status
NCT00415519
Efficacy and Safety Study of MCI-186 for Treatment of Amyotrophic Lateral Sclerosis (ALS) Who Met Severity Classification IIItreatment3completed
NCT05395624
Safety, PK and Biodistribution of 18F-OP-801 in Patients With ALS, AD, MS, PD and Healthy VolunteersNo drug interventionsdiagnostic1 / 2recruiting
NCT03800524
Safety and Efficacy of TUDCA as add-on Treatment in Patients Affected by ALStreatment3active_not_recruiting
NCT04505358
Evaluate PU-AD in Subjects With Amyotrophic Lateral SclerosisNo drug interventionstreatment2withdrawn
NCT01803386
Noninvasive Assessment of Neuromuscular Disease Using Electrical Impedance MyographyNo drug interventionsNot AvailableNot Availablecompleted
NCT00069186
Study of Creatine Monohydrate in Patients With Amyotrophic Lateral SclerosisNo drug interventionstreatment3unknown_status
NCT01492686
Phase 3 Study of MCI-186 for Treatment of Amyotrophic Lateral Sclerosistreatment3completed
NCT03088839
Circulating Biomarker for Amyotrophic Lateral Sclerosis (ALS)No drug interventionsNot AvailableNot Availablerecruiting
NCT02365922
Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)No drug interventionsNot AvailableNot Availablecompleted
NCT01835782
Determining the Safety of L-serine in ALStreatment1 / 2unknown_status
NCT03755167
A Follow up Study to Protocol 101/2 - Continued Treatment by IPL344 IVtreatment2suspended
NCT00403104
Placebo Controlled Study of ONO2506PO in the Presence of Riluzole in Patients With Amyotrophic Lateral Sclerosis (ALS)treatment2completed
NCT00876772
Olanzapine for the Treatment of Appetite Loss in Amyotrophic Lateral Sclerosis (ALS)treatment2 / 3completed
NCT02559869
Imaging and BioFluid Biomarkers in Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availablecompleted
NCT00214110
Tamoxifen Therapy in Amyotrophic Lateral Sclerosis [ALS]Not Available2completed
NCT01232738
Trial of Safety and Efficacy of Rasagiline in Patients With Amyotrophic Lateral Sclerosis (ALS)treatment2completed
NCT01699451
DNA, Blood and Skin Cell Repository for Research on ALS and Related Neurodegenerative Disorders at Mayo Clinic FloridaNo drug interventionsNot AvailableNot Availablecompleted
NCT02118805
Innovative Measures of Speech and Swallowing Dysfunction in Neurological DisordersNo drug interventionsNot AvailableNot Availablecompleted
NCT02236897
PET Imaging in ALS PatientsNo drug interventionsdiagnosticNot Availablecompleted
NCT04866771
Remotely Supervised tDCS for Slowing ALS Disease ProgressionNo drug interventionstreatmentNot Availableactive_not_recruiting
NCT01884571
Immunosuppression in Amyotrophic Lateral Sclerosis (ALS)treatment2completed
NCT03280056
Safety and Efficacy of Repeated Administrations of NurOwn® in ALS Patientstreatment3completed
NCT01277315
Safety and Tolerability of Anakinra in Combination With Riluzol in Amyotrophic Lateral Sclerosistreatment2completed
NCT00821132
Genetics of Familial and Sporadic ALSNo drug interventionsNot AvailableNot Availablecompleted
NCT02152449
Oral Nutritional Supplementation in Amyotrophic Lateral Sclerosis (ALS) PatientsNo drug interventionstreatmentNot Availablecompleted
NCT02759913
A Study to Evaluate the Performance of a Diagnostic Test in ALSNo drug interventionsNot AvailableNot Availableunknown_status
NCT00444613
A Study in Patients With Amyotrophic Lateral Sclerosis (ALS)treatment2 / 3completed
NCT00694941
A Phase II Multi-centre, Extension Study to Investigate the Long Term Safety of ONO-2506PO in Patients Diagnosed With Amyotrophic Lateral Sclerosis (ALS)treatment2completed
NCT03580616
Tolerability and Efficacy of L-Serine in Patients With Amyotrophic Lateral Sclerosis (ALS)treatment2terminated
NCT02936635
A Study for Patients Who Completed VITALITY-ALS (CY 4031)treatment3completed
NCT00424463
Expanded Controlled Study of Safety and Efficacy of MCI-186 in Patients With Amyotrophic Lateral Sclerosis (ALS)treatment3completed
NCT02463825
A Registry-Based Clinical Trial of Pimozide in Patients With Neuromuscular Junction Transmission Dysfunction Due to ALStreatment2unknown_status
NCT04244630
Mitochondrial Capacity Boost in ALS (MICABO-ALS) TrialNo drug interventionstreatment2unknown_status
NCT02414230
F 18 T807 Tau PET Imaging in Familial Amyotrophic Lateral SclerosisNot AvailableNot Availablecompleted
NCT01806857
Clinical Trial Nuedexta in Subjects With ALStreatment2completed
NCT01363882
Polysomnography-directed Noninvasive Ventilation in Amyotrophic Lateral Sclerosis (ALS)No drug interventionssupportive_careNot Availableterminated
NCT05995782
A Phase 1, SAD and MAD Study to Evaluate the Safety and Tolerability of FB418No drug interventionstreatment1not_yet_recruiting
NCT03645031
Acute Intermittent Hypoxia and Breathing in Neuromuscular DiseaseNo drug interventionstreatmentNot Availablecompleted
NCT01366027
PRISM Registry: Pseudobulbar Affect Registry SeriesNo drug interventionsNot AvailableNot Availablecompleted
NCT00244244
A Multicenter, Dose Ranging Safety and Pharmacokinetics Study of Arimoclomol in ALStreatment2completed
NCT00231140
Pilot-Study of Thalidomide in Amyotrophic Lateral Sclerosis (ALS)treatment2terminated
NCT04577404
Safety Extension Study of Oral Edaravone Administered in Subjects With Amyotrophic Lateral Sclerosis (ALS)treatment3completed
NCT00445172
A Long-Term Study in Patients With Amyotrophic Lateral Sclerosis (ALS)treatment2 / 3completed
NCT02424669
Neuroinflammation in Amyotrophic Lateral Sclerosis - Mechanisms and Therapeutic Perspectives: a Translational Pilot Study Among ALS PatientsNo drug interventionsNot AvailableNot Availableunknown_status
NCT03233646
Retinal Imaging in Neurodegenerative DiseaseNo drug interventionsNot AvailableNot Availablerecruiting
NCT02017912
Phase 2, Randomized, Double Blind, Placebo Controlled Multicenter Study of Autologous MSC-NTF Cells in Patients With ALStreatment2completed
NCT01746381
Non-invasive Ventilation in Amyotrophic Lateral Sclerosis (ALS) Using the iVAPS ModeNo drug interventionstreatmentNot Availablecompleted
NCT00330681
Efficacy and Safety Study of MCI-186 for Treatment of Amyotrophic Lateral Sclerosis (ALS)treatment3completed
NCT01938495
Diaphragm Pacing System (DPS) In Participants With Amyotrophic Lateral Sclerosis (ALS)No drug interventionssupportive_care2completed
NCT04090684
Ciprofloxacin/Celecoxib Combination in Patients With ALStreatment1completed
NCT03241784
T-Regulatory Cells in Amyotrophic Lateral Sclerosistreatment1unknown_status
NCT02164253
Focal Accumulation of Iron in Cerebral Regions in Early ALS (Amyotrophic Lateral Sclerosis) Patientssupportive_care2completed
NCT02286011
Intramuscular Infusion of Autologous Bone Marrow Stem Cells in Patients With Amyotrophic Lateral SclerosisNo drug interventionstreatment1unknown_status
NCT02528071
Prognostic Value of a Diaphragmatic Endurance Test in Patients With Amyotrophic Lateral SclerosisNo drug interventionsNot AvailableNot Availableterminated
NCT00786032
A Clinical Demonstration of EEG Brain-computer Interface for ALS PatientsNo drug interventionsNot AvailableNot Availablecompleted
NCT02709330
ALS Reversals - Lunasin Regimentreatment2completed
NCT04849065
Clinical Trial on the Use of Cell Therapy in the Treatment of Patients With Amyotrophic Lateral SclerosisNo drug interventionstreatment2unknown_status
NCT03787420
Development and Needs Assessment and Efficiency of Smart Communication System for Patients With ALS.No drug interventionsotherNot Availableunknown_status
NCT02891629
Safety and Feasibility of the EyeControl DeviceNo drug interventionssupportive_careNot Availablecompleted
NCT04055623
T-regulatory Cells in ALStreatment2unknown_status
NCT05663008
Impairments of Neuro-muscular Communication in Motor-Neuron Disease: A Bio-Marker for Early and Personalised DiagnosisNo drug interventionsNot AvailableNot Availablerecruiting
NCT03330353
Chromatic Pupillometry to Assess the Melanopsin-Light Pathway in Progressive Supranuclear PalsyNo drug interventionsNot AvailableNot Availableunknown_status
NCT05276349
Home-based Remote Digital Monitoring to Assess ALS Progression (Track ALS)No drug interventionsNot AvailableNot Availableactive_not_recruiting
NCT03482050
A Study to Evaluate Transplantation of Astrocytes Derived From Human Embryonic Stem Cells, in Patients With Amyotrophic Lateral Sclerosis (ALS)treatment1 / 2completed
NCT03081338
A Programme for Amyotrophic Lateral Sclerosis Care in EuropeNo drug interventionsNot AvailableNot Availableunknown_status
NCT04715399
UPenn Observational Research Repository on Neurodegenerative DiseaseNo drug interventionsNot AvailableNot Availablerecruiting